Term
| If a dosing interval is less than the half-life of a drug, what does this result in? |
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Definition
| Higher steady state levels and a greater degree of accumulation |
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Term
| How does a smaller volume of distribution affect the flucutation of peak and trough levels? |
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Definition
| Results in a greater fluctuation between peak and trough levels |
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Term
How does a larger initial plasma concentration affect the fluctuation of peak and trough levels?
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Definition
| It results in a greater flucutation between peak and trough levels. |
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Term
| When interval is equal to half-life, what can we assume? |
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Definition
| After one interval, 50% of drug is gone, after two intervals, 75% is gone, etc. |
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Term
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Definition
In the exponential rate plot equation equation, divide Ke Dose by Dose. Sounds simple....
Ex: If dose was 400mg...
Ae/t = 31.62e-Ktmidpnt
ke = 31.62/400 = 0.079h-1 |
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Term
| How do you find the renal clearance? |
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Definition
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