Term
| Peak concentration values can be used to quantitate the amount of drug absorbed after oral administration |
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Definition
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Term
| When writing a differential equation, a first order process is represented by a rate constant times the amount remaining to undergo the process |
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Definition
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Term
| A linear plot of exp(-x) versus exponent represents an exponential decay |
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Definition
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Term
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Definition
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Term
| Elimination includes excretion and metabolism |
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Definition
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Term
| According to the two compartment pharmacokinetic model drug concentration reaches rapid equilibrium in only part of the body |
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Definition
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Term
| Peak salicylamide concentrations after oral administration are not proportional to dose because the first pass metabolism can be saturated |
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Definition
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Term
| Some of the parameters of the two compartment model include k12, k21, k10 |
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Definition
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Term
| Appropriate units for CL are ml/min |
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Definition
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Term
| With a linear model doubling the dose will result in doubling the concentration |
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Definition
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Term
| A useful equation for determining V is V = Dose/Cp(0) |
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Definition
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Term
| A linear model means elimination is first order |
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Definition
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Term
| A one compartment model means that drug in the blood is in rapid equilibration with drug in extravascular tissues |
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Definition
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Term
| The fraction excreted as unchanged drug can be calculated as ke/kel |
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Definition
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Term
| Clearance can be calculated as Dose/AUC |
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Definition
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Term
| The fraction excreted as unchanged drug can be calculated as U∞/Dose |
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Definition
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Term
| Clearance can be calculated as dU/(dt • Cp) |
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Definition
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Term
| Plotting A.R.E. versus time on semi-log graph paper will provide a straight line and fe can be calculated from the intercept |
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Definition
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Term
| The infusion rate required to produce a steady state concentration can be calculated as kel * V * Cp(ss) |
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Definition
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Term
| A zero order infusion rate is included as k0 when writing a differential equation |
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Definition
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Term
| Infusion rates are usually zero order |
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Definition
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Term
| If the infusion rate is doubled the steady state concentration will be doubled |
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Definition
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Term
| Steady state drug concentrations after an IV infusion can be calculated as k0/(kel * V) |
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Definition
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Term
| Steady state drug concentrations after an IV infusion can be calculated as k0/(CL) |
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Definition
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Term
| Absorption via the rectal ROA is commonly erratic and incomplete |
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Definition
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Term
| Because of the good blood supply to the site of absorption buccal administration is usually quite rapid |
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Definition
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Term
| With all other parameters the same increasing the ka value will result in higher Cp(peak) and lower t(peak) values |
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Definition
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Term
| When the absorption rate constant is slower than the elimination rate constant this is called a 'flip-flop' |
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Definition
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Term
| The time of peak drug concentration after oral administration is independent of dose |
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Definition
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Term
| If all the assumptions for the Method of Residuals are obeyed and kel is smaller than ka then kel can be determined from the terminal semi-log slope of Cp versus time after oral administration |
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Definition
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Term
| A major advantage of the Wagner-Nelson method is that the absorption process doesn\'t have to be first order |
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Definition
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Term
| With only oral data it is not possible to determine separate values of F and V |
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Definition
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Term
| After oral administration the slope of the drug concentration versus time at later times on semi-log paper will represent the slower rate constant |
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Definition
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Term
| When writing a differential equation, a zero order process is represented by a rate constant times the amount remaining to undergo the process |
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Definition
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Term
| In the equation, dX/dt = -k*X, k represents the rate of change of X with respect to t |
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Definition
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Term
| All penicillin salts dissolve at the same rate |
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Definition
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Term
| According to the two compartment model drug concentrations will be in equilibrium throughout the body very shortly after an IV bolus dose |
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Definition
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Term
| Elimination includes distribution and metabolism |
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Definition
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Term
| The differential equation for Cp (one compartment linear model) is Cp = (Dose/V) * exp(-kel*t) |
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Definition
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Term
| The differential equation for the rate of change of Cp (one compartment linear model) is dCp/dt = -kel |
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Definition
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Term
| If a drug is eliminated by first order kinetics then it must follow a one compartment model |
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Definition
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Term
| The rate of change of concentration plotted versus concentration results in a straight line with a positive slope |
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Definition
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Term
| The apparent volume of distribution is always the same as the volume of the patient |
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Definition
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Term
| Three assumptions for a one compartment model are rapid equilibration, rapid mixing in blood and linear elimination |
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Definition
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Term
| For a linear model the rate constant for elimination is proportional to the amount of drug remaining to be eliminated |
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Definition
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Term
| Plotting A.R.E. versus time on semi-log graph paper will provide a straight line and fe can be calculated from the slope |
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Definition
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Term
| Infusion rates are usually first order |
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Definition
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Term
| Buccal tablets provide rapid release and absorption of drugs such as nitroglycerin |
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Definition
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Term
| The value of tmax observed after oral administration is dependent on the values of F and ka |
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Definition
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Term
| With all other parameters the same increasing the F value will result in higher Cp(peak) and lower t(peak) values |
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Definition
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