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Pharmaceutics
Exam 3 Review
15
Biology
Graduate
04/02/2012

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Term
non aqueous vehicles/solvents
Definition
-veg oil
-glycerin
-propylene glycol
-PEG
-alcohol
Term
preservatives
Definition
-benzoic acid
-benzyl alcohol
-paraben
-phenols
-quaternary ammonium salts
-mercurials (thimerosal)
Term
solubilizing agents
Definition
-pH mods
-solvents
-sufactants
-complexing agents
Term
surfactants
Definition
-polsorbate (Tween)
Term
complexing agent
Definition
-cyclodextrin
Term
stabilizers
Definition
-antioxidants
-pH mods
-chelating agents
-cryo/lyoprotectants
-inert gases
Term
water antioxidant
Definition
ascorbic acid
Term
lipid antioxidant
Definition
-tocopherol
Term
chelating agent
Definition
EDTA and citric acid
Term
improve protein stability
Definition
-cryo/lyoprotectants
-pH/buffers
-surfactants
-serum albumin
-antifoaming agents
Term
immunogenicity
Definition
-structure (variation, aggregation, glycosylation)
-impurites
-formulation
-route of administration
Term
ionic strength effects
Definition
-preservative efficacy
-solubility/stability
-non electrolyte tonicity agents
Term
viscosity enhancers
Definition
-methylcellulose
-HPMC
-PVA
-tear replacement
-eye lube
Term
ophthalmic preservatives
Definition
borate/EDTA
benzalkonium chloride
Term
ointment/gel sterilization
Definition
-aseptic only!
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