Term
|
Definition
-solid dosage forms intended for a BODY ORIFICE where they melt, soften, or dissolved
-localized or systemic |
|
|
Term
|
Definition
| -suppositories for vaginal use |
|
|
Term
| vaginal inserts usually prepared by |
|
Definition
|
|
Term
| rectal suppository characteristics |
|
Definition
-usually 1.5 inches
-drug is 0.1% to 40% |
|
|
Term
|
Definition
| -pain and itching-hemorrhoids |
|
|
Term
|
Definition
-many drugs
-analgesics, nausea/vomiting |
|
|
Term
| rectum anatomy and physiology |
|
Definition
-15-20cm
-3ml mucous
-drug passes though rectum wall to vascular area of submucosal wall
-drug can be carried by 3 veins |
|
|
Term
| superior rectal vein empties into |
|
Definition
|
|
Term
| middle/inferior rectal vein empty into |
|
Definition
-general circulation
-most common
-AVOID first pass |
|
|
Term
| desired characteristics for suppository bases |
|
Definition
-solid at room temp
-pourable when prepared |
|
|
Term
|
Definition
-oleaginous
-water soluble
-misc. |
|
|
Term
|
Definition
-cocoa butter
-polymorph
-beta is preferred |
|
|
Term
|
Definition
|
|
Term
|
Definition
-glycerol
-macrogels (PEG) |
|
|
Term
|
Definition
-gelatin or soap base
-used for laxative purpose and vaginal application
-slower to soften and mix than oil bases (dissolve)
-tendency to absorb moisture
-may moisten with water before insertion |
|
|
Term
|
Definition
-have higher melting points
-dissolve rather than melt
-slower release of drug
-no refrigeration needed |
|
|
Term
|
Definition
-mixture of fatty and water bases
-must be emulsions
-Poloxyl 40 stearate (surfactant) |
|
|
Term
|
Definition
-drug diffuses slowly
-base melts quickly |
|
|
Term
|
Definition
-drug diffuses quicker
-base dissolves slowly |
|
|
Term
|
Definition
-compression
-hand rolling/shaping
-fusion/melt molding |
|
|
Term
|
Definition
-forces mass of base and drug into a mold
-friction in mixing causes base to form paste like consistency
-good for heat labile drugs, insoluble drugs
-no risk of drug settling |
|
|
Term
|
Definition
-historic preparation, obsolete with readily available molds
-avoids head and molds |
|
|
Term
|
Definition
-most common
-5 steps
-melt the base
-incorporate drug
-pour into mold
-cool
-remove from mold |
|
|
Term
|
Definition
| stainless steel, aluminum, brass, plastic |
|
|
Term
|
Definition
-lubrication of the mold
-mineral oil or equivalent
-needed for glycerated gelatin supp
-PEG,cocoa butter not needed?
- |
|
|
Term
|
Definition
| weight of drug/weight of base displaced |
|
|
Term
|
Definition
-weight up to 5 g
-some systemic drug absorption for vaginal wall
-decreased first pass effect
-vaginal epithelium is significantly impermeable to drugs
-most LOCAL |
|
|
Term
|
Definition
-PEG
-may add surfactants and parabens |
|
|
Term
|
Definition
|
|
Term
|
Definition
-cocoa butter is base
-female-50mm 2g
-male-125mm 4g |
|
|
Term
|
Definition
| -medicated urethral system for erection |
|
|
Term
|
Definition
|
|
Term
| cocoa butter supp must be |
|
Definition
|
|
Term
|
Definition
|
|
