Term
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Definition
| -a solid dosage form prepared by compression or molding |
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Term
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Definition
-oral ingestion
-oral cavity
-vaginal tablets
-dispensing tablets (compounding tablets, high amount of drug)
-hypodermic tablets |
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Term
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Definition
-scored tablets
-caplets
-film coated
-sugar coated
-geltab
-gelcap |
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Term
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Definition
-required by FDA (1995)
-for all solid dosage forms for human use
-product specific ID codes
-can be embossed, debossed(engraved), or printed |
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Term
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Definition
| -prepared by tablet press with the use of dies and punches |
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Term
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Definition
-manual operation
-place pre-filled punch/tooling set between plates
-apply pressure |
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Term
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Definition
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Term
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Definition
-multi-station
-up to 10k tablets/min |
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Term
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Definition
-uniform mix
-flowability
-compactability
-no adhesion to metal tooling |
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Term
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Definition
-compressability
-bonding
-minimal elastic recovery |
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Term
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Definition
-weight variation
-content uniformity
-tablet hardness
-mottling
-capping
-sticking and picking |
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Term
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Definition
| uneven distribution of color |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| a particle size enlargement process after which the initial primary particles can still be identified |
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Term
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Definition
-weight and blending
-preparing a damp mass
-screening damp mass into granules
-drying the granulation
-sizing the granulation by dry screening
-adding lubricant and blending
-tableting |
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Term
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Definition
-active ingredient
-diluent
-binder
-disintegrant |
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Term
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Definition
-use agitated mixer/fluid bed processor
-add water while mixing
-avoid over granulation |
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Term
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Definition
-oven
-one-pot
-fluid bed systems |
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Term
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Definition
-dry screening (12-20 mesh screens)
-target granule size depends on tablet size |
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Term
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Definition
-mix the lubricant with granulation
-improves flow
-prevents adhesion |
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Term
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Definition
-entire granulation process completed in one apparatus
-containment of potent drugs |
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Term
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Definition
-pre blends the formulation though air flow
-sprays liquid binder on powder while circulating
-dries granulated product |
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Term
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Definition
-powder mixture is compacted into large pieces and sized into granules
-ex. slugging,roller compaction |
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Term
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Definition
-smooth finish
-need sealing coats for moisture sensitive drugs
-printing necessary
-multistep process |
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Term
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Definition
-thin,polymer coating
-durable
-colored or clear
-coating reveals embossment
-in a coating pan or fluid bed |
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Term
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Definition
-gelatin coating
-2 sheets of gelatin by cold shrink process
-made to look like a capsule |
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Term
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Definition
-multi-layer tablets
-compression coated tablets (tablet within a tablet)
-for aesthetics,compatibility, staged release |
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Term
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Definition
-aka tablet triturates
-30-250mg each
-lactose or sucrose base
-prepared in a mold |
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Term
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Definition
-contains sodium bicarbonate and acids
-usually large compressed tablets
-dissolve in water before administration |
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Term
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Definition
-disintegrates in mouth with or without chewing
-no water needed
-prepared by wet granulation and compression |
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Term
| orally disintegrating tablets |
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Definition
-dissolve in less than 1 min
-prepared by molding and drying or soft compression
-no water needed |
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Term
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Definition
-uncoated bullet shaped
-prepared by direct compression
-dispensed with applicator |
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Term
| most marketed tablets manufactured by |
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Definition
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Term
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Definition
| density and powder fill volume |
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Term
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Definition
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Term
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Definition
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Term
| property that does not impact bioavailability |
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Definition
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