Term
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Definition
-imaging procedures
-in vivo function studies
-therapeutic procedures |
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Term
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Definition
-dynamic imaging (kidney function)
-static imaging (brain and liver scans) |
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Term
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Definition
-ability of tissue to do what it does normally
-thyroid uptake of iodine
-whole blood volume
-vitamin B12 absorption from the GI |
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Term
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Definition
-hyperthyroidism (radioactive iodine)
-cancer (antibodies to specific areas)
-radioimmunotherapy (tagged antibodies) |
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Term
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Definition
-emission and propagation of energy through space
-radiation can be particulate (apla and beta particles) or electromagnetic (gamma or x rays) is measures by KeV or MeV (electron volts)
-beta particles can be negatrons (B-) or positrons (B+)
-they are created by the decay of various unstable elements that have an unstable ratio of neutrons to protons (greater than or less than 1) |
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Term
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Definition
-the amount of energy release and type of energy (particulate or electromagnetic) determine the effects of radiation on living organisms
-the amount of energy released is proportional to the dose of the radiopharmaceutical (dosimetry)
-dose is usually expressed a s the number of decay or disintergrations per minute (DPM) or millcuries (mCi) or microcuries at some standard point in time rather than mg or g
-the dose of a radiopharmaceutical depends on the type of energy released and the specific nuclear medicine procedure being used |
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Term
| the dose of a radiopharmaceutical (A) can be calculated from |
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Definition
-decay constant of radionuclide (gamma)
-half life of the radionuclide
-initial amount of radionuclide (Ao)
-elapsed time between A and Ao (t) |
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Term
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Definition
| -relate t to the fraction of activity of a radionuclide remaining, are used to determine the final dose as well as when it should be prepared and the scheduling of its use |
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Term
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Definition
| -process by which an unstable element emits radiation to form a stable element |
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Term
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Definition
| 13-purchased in sterile cylinders or "cows" then "milked" each day with sterile saline to obtain solutions of 99% pure 99mTc which can be formulated into a variety of compound salts, colloids. proteins |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| -units for amount of radiation energy that is absorbed by tissue/body |
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Term
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Definition
| -badges, rings, necklaces, bracelets |
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Term
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Definition
-liquid sintilation counter
-detect low energy nuclides (B- emitters like 3H) |
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Term
| Gamma cameras, PET/SPECT scanners, Geiger counters |
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Definition
| -detect high energy nuclides (B-, B+, gamma like 131I or 99mTc) |
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Term
| radiation can be absorbed by |
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Definition
| -lead, wood, glass, Lucite |
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Term
| do not require protection |
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Definition
-radioligands
-receptor binding studies
-PK |
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Term
| factors for dose/products |
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Definition
-t1/2
-weight age gender
-renal function and existing conditions |
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Term
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Definition
-board certified nuclear pharmacist
-train in dosimetry, radiation safey, dx and tx |
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Term
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Definition
-rapid delivery and distribution
-rapid preparation time (t1/2 usually hours)
-quality control (chemical/isotopic purity)
-sterility
-selective tissue uptake and accumulation
-t1/2 long enough for medical procedure but short enough to decrease exposure risk |
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