Term
|
Definition
Type
mAb
Target/Mechanism
Blocks IL-6 receptor ligand
Indication
Rheumatoid arthritis |
|
|
Term
|
Definition
Type
Gene therapy
Target/Mechanism
Express p53 to promote apoptosis
Indication
Head and neck cancer |
|
|
Term
|
Definition
Type
Gene therapy
Target/Mechanism
Express MHC class 1 complex
Indication
Melanoma |
|
|
Term
|
Definition
Type
Ligand Fc fusion
Target/Mechanism
CD2 ligand fused to Fc
Indication
Chronic plaque psoriasis |
|
|
Term
|
Definition
Type
Double stranded RNA
Target/Mechanism
Toll-like receptor 3 activator
Indication
HIV, chronic fatigue syndrome |
|
|
Term
|
Definition
Type
Receptor Fc fusion
Target/Mechanism
TACI receptor fused to Fc
Indication
Systemic lupus |
|
|
Term
|
Definition
Type
Peptide
Target/Mechanism
Neutralize B-lymphocyte stimulator
Indication
Systemic lupus |
|
|
Term
|
Definition
Type
Recombinant enzyme
Target/Mechanism
Replacement of beta-glucocerebrosidase
Indication
Inherited lysosomal storage disorder |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Neutralize TNA-alpha
Indication
Rheumatoid arthritis |
|
|
Term
|
Definition
Type
Vaccine
Target/Mechanism
Angiotensin II vaccine
Indication
HTN |
|
|
Term
|
Definition
Type
Lipopolysaccharide analog
Target/Mechanism
Toll-like receptor 4 activator
Indication
Sepsis |
|
|
Term
|
Definition
Type
Antisense
Target/Mechanism
Blocks Bcl-2 to promote apoptosis
Indication
Various cancer |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Neutralize IL-1 beta
Indication
Cryopyrin-associated periodic syndrome |
|
|
Term
|
Definition
Type
Peptide
Target/Mechanism
Blocks bradykinin production
Indication
Hereditary angioedema |
|
|
Term
|
Definition
Type
Fab fragment
Target/Mechanism
Blocks VEGF activity
Indication
Wet age-related macular degeneration |
|
|
Term
|
Definition
Type
Aptamer
Target/Mechanism
Blocks VEGF activity
Indication
Wet age-related macular degeneratio |
|
|
Term
|
Definition
Type
Antisense
Target/Mechanism
Inhibits apolipoprotein B synthesis
Indication
High cholesterol |
|
|
Term
|
Definition
Type
Gene therapy
Target/Mechanism
Express cardiac enzyme
Indication
Advanced HF |
|
|
Term
|
Definition
Type
Fusion
Target/Mechanism
Deliver toxin to CD25 cells
Indication
T-cell lymphoma |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Suppress CD3 T-cells
Indication
T1DM |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Blocks HER2 dimerization
Indication
Breast cancer |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Binds A-beta peptide for clearance
Indication
Alzheimers Disease |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Inhibits osteoclast formation
Indication
Postmenopausal osteoporosis |
|
|
Term
|
Definition
Type
Cell therapy
Target/Mechanism
Autologous cellular immunotherapy
Indication
Advanced prostate cancer |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Neutralizes IL-5
Indication
Eosinophilic esophagitis |
|
|
Term
|
Definition
Type
Gene therapy
Target/Mechanism
Targeted expression to suppress cyclin 1
Indication
Various cancers |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Neutralize TNF-alpha
Indication
Psoriatic and rheumatoid arthritis |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Beta-amyloid
Indication
Alzheimer's disease |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Neutralize IL-12 and IL-23
Indication
Plaque psoriasis |
|
|
Term
|
Definition
Type
Peptide
Target/Mechanism
Amylin replacement
Indication
Type 1 and type 2 DM |
|
|
Term
|
Definition
Type
Vaccine
Target/Mechanism
Cocaine vaccine
Indication
Cocaine addiction |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Neutralize nerve growth factor
Indication
Chronic pain |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Phosphotidylserine
Indication
Hep C viral infection |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Blocks EGFR ligands
Indication
Metastatic colorectal carcinoma |
|
|
Term
|
Definition
Type
Antisense
Target/Mechanism
Blocks VEGF activity
Indication
Various cancers |
|
|
Term
|
Definition
Type
mAb
Target/Mechanism
Blocks T-cell IL-2 receptor
Indication
Transplant rejection |
|
|
