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Pharm-VET-GI
Drugs affecting GI system flashcards
37
Veterinary Medicine
Not Applicable
02/23/2013

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Cards

Term
Who is considered "foregut fermentors"?
Definition
Ruminants
Term
Who is considered "hind-gut fermentors"?
Definition
Horses and rodents
Term
In cows, or other ruminants...what does the rumen and reticulum do?
Definition
Receive and mix swallowed food
Term
What does the omasum and abomasum do?
Definition
Mixes, digests, and absorbs
Term
In horses, or rodents...what do they do?
Definition
expand their colon and cecum
Term
Nervous system is broken down into what?
Definition
Central nervous system, and autonomic nervous system
Term
The autonomic nervous system is broken down into what two subdivisions? (I don't know how else to word it?)
Definition
Sympathetic and parasympathetic
Term
Talking about parasympathetic nervous system...what does the vagus nerve do?
Definition
Increases digestive secretions
Increases blood flow to GI tract
Increases GI smooth muscle tone and mobility
Increases digestion and absorption (aka net effect)
Term
What exerts GI effects more local (rather than controlling whole GI tract?)
Definition
Hormones (gastrin, histamine) and prostaglandins
Term
What are parietal cells also known as?
Definition
Oxyntic cells
Term
What do these parietal cells have receptors for?
(hint: they're hormones)
Definition
Gastrin, histamine, and acetylcholine
Term
Parietal cells release what into the gastric lumen?
Definition
Hydrochloric acid
Term
The more full the receptors are, the more _____ the cell will be.
Definition
Stimulated, or active
Term
What does acetylcholine do?
Definition
Causes parietal cells to release hydrochloric acid
Term
Gastrin is released from where?
Definition
Stomach wall
Term
What is it in response to?
Definition
Presence of proteins in stomach, gastric distension, parasympathetic stimulation
Term
So, what does gastrin do?
Definition
"HEY! GET READY...FOODS COMING!!"
Term
No, really-what does Gastrin do?
Definition
-Stimulates the parietal cells to release HCl into the stomach lumen
-Relaxes the stomach smooth muscle, gets it ready to receive noms
-Evacuates the colon (gastro-colic reflex)
Term
Moving onto histamine...who's it released by?
Definition
Basophils and mast cells.
Term
During when is histamine released?
Definition
During inflammation or allergic reactions
Term
H-1 receptors?
Definition
Skin, resp tract, vascular tissue, smooth muscle, brain
Term
H-2 receptors?
Definition
Stomach *parietal* cells
Term
Do prostaglandins circulate, or do they act locally? Or both?
Definition
Local! They don't circulate! Aint no prostaglandin got time fo dat!
Term
Two different kinds of prostaglandins, name em...
Definition
-Protective
-Inflammatory
Term
Effects of protective prostaglandins?
Definition
Increase GI mucus production
Increase intestinal motility (keeps cooties from staying in one place too long)
Increase local blood flow (brings nutrients to cells & yo hawt bod)
Increase HCO3 in mucus (nutrilizes HCl)
Term
What inhibits the protective prostaglandins? :(
Definition
NSAIDs, like Asprin, Rimadyl, Etogesic, Metacam.
It damages the GI tract due to the loss of that protective-ness...
Term
Vomiting center is also known as?
Definition
Emetic center
Term
Where is the emetic center located?
Definition
Brainstem, more specifically-medulla
Term
The vomiting has what two receptors?
Definition
Alpha and seratonin
Term
So, by blocking these receptors...what is the result?
Definition
Reduces vomiting! Duhhhh.
Term
Which receptor is sensitive to our feline friends?
Definition
Alpha
Term
The vomiting center receives info from where?
Definition
Vagus nerve, Chemoreceptor Trigger Zone (CRTZ), Vestibular apparatus, Cerebrum
Term
Vagus nerve was stimulated by distension/irritation of what?
Definition
Pharynx, stomach, duodenum, peritoneum, kidney, gall bladder, and uterus
Term
Where is the CRTZ located?
Definition
In the brain, the floor of the 4th ventricle (remember dat?)
Term
Nerve endings in blood and in CSF detect when?
Definition
-Chemical toxins
-Bacterial toxins
-Azotemia
-Ketones (by product of fat-NOT suppose to be in blood)
-Opiates
Term
So our kitty and doggy fwiends have certain receptors in the CRTZ that makes emetic drugs more effective...
Kitty receptors? Doggy receptors?
Definition
Kitty: Alpha receptors, and serotonin
Doggy: Dopamine receptors, and histamine receptors
Term
The vestibular apparatus is located where?
Definition
Inner ear
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