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Pharm - URI
URI
51
Pharmacology
Graduate
03/21/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
What are the 3 most common bacteria in AOM?
Definition
1. Strep pneumoniae 40-50%
2. Haemophilis influenzae 30-40%
3. Moraxell catarrhalis 10-15%
Term
What percentage of Step pneumoniae are resistant to penicillin? Cephalosporins? Trimethoprim/sulfamethoxazole (Bacterim)?
Definition
1. 50%
2. 4-30%
3. >40%
Term
What are the only oral drugs effective against serotype 19A Strep pneumoniae?
Definition
fluoroquinolones or linezolid
Term
What 3 factors must be present in order to diagnose OM?
Definition
1. History of acute onset
2. Signs of middle ear effusion - immobile, bulging TM
3. Middle ear inflammation - erythema of the TM, otalgia
Term
What is the gold standard for diagnosis of OM?
Definition
tympanocentesis
Term
When is tympanocentesis appropriate?
Definition
1. child with sepsis
2. treatment failure with multiple abx with possible hearing loss
3. children with immune deficiencies (likely atypical pathogen)
Term
What % of OM cases resolve spontaneously?
Definition
70-90% in 7-14 days
Term
What is the most common indication for prescribing abx?
Definition
AOM
Term
What is the first line of treatment for uncomplicated AOM?
Definition
1.
Amoxicillin - safe, inexpensive, acceptable taste, and narrow microbiologic spectrum
Term
What is the low dose of amoxicillin for AOM? High dose?
Definition
40-45 mg/kg/day in divided doses BID x 10 days

80-90 mg/kg/day in divided doses BID x 10 days
Term
What is the dosing for amoxicillin/clavulanate for AOM?
Definition
1. amoxicillin 80-90 mg/kg/day
2. clavulanate 6.4 mg/kg/day
3. divided doses BID x 10 days
Term
What is the dosing of Clindamycin for AOM after treatment failure?
Definition
17-25 mg/kg/day in 3-4 doses x 10 days
Term
What are some risk factors for AOM recurrence?
Definition
1. younger than 15 months
2. hx of recurrent AOM in this child or sibling
3. male sex
4. not being breastfed
5. bilateral disease
6. day care
7. winter months
8. passive smoking
Term
Tympanometry is not reliable in infants younger than ____.
Definition
7 months
Term
How do you help prevent AOM?
Definition
1. alter day care attendance
2. breastfeed for first 6 months
3. avoid supine bottle feeding
4. reduce/eliminate pacifier use
5. pneumococcal conjugate vaccine
Term
What % of OE are bacterial?
Definition
90%
Term
What type of OE infection has a green, foul-smelling discharge?
Definition
Pseudomonas aeruginosa
Term
What % of OE are fungal?
Definition
10%
Term
What does fluffy gray to bluish green discharge suggest?
Definition
Aspergillus
Term
What abxs are used to treat OE>
Definition
Colistin/neomycin/hydrocotisone
ofloxacin
ciprofloxacin/dexamethasone
Term
What is a contraindication for the use of colistin/neomycin/hydrocortisone?
Definition
perforated TM
Term
Which medication is approved for treatment of OE with perforated TM?
Definition
ofloxacin
Term
When is ciprofloaxin/dexamethasone (steroid) contraindicated?
Definition
viral or fungal infection
Term
What % of patients treated for chronic OE had a positive skin patch test for neomycin allergy?
Definition
13%
Term
How do you treat fungal OE?
Definition
2% acetic acid solution
1% clotrimazole
tolnafate
Term
When is a wick indicated?
Definition
When the ear canal is narrowed by 50%, remove in 2-3 days
Term
How long should treatment of otitis externa last?
Definition
5-10 days
Term
What is the 5th most common condition for which abx are prescribed in the U.S.?
Definition
Acute bacterial rhinosinusitis
Term
How many days must a patient be symptomatic before it is no longer assumed to be VIRAL rhinosinusitis?
Definition
10 days
Term
hat meds are useful for rhinosinusitis?
Definition
oxymetazoline
phenylephrine
azelastine
use 1-3 days only
Term
What % of Community Acquired Acture bacterial rhinosinusitis are caused by Haemophilis influenzae? Strep pneumoniae?
Definition
35%

34%
Term
What 4 items are on the diagnostic point system for acute bacterial rhinosinusitis?
Definition
1. purulent nasal discharge - worse on one side
2. bilateral rhinorrhea
3. unilateral maxillary sinus tenderness (or frontal sinus tenderness)
4. Pus in the nasal cavity on examination
Term
What is the likelihood of ABRS if 3-4 points? 2 points? 0-1 points?
Definition
1. 85%
2. 50%
3. 4%
Term
What type of fever favors diagnosis of ABRS?
Definition
high fever
Term
How do you treat ABRS in peds?
Definition
1. high dose amoxicillin
2. high dose amoxicillin/clavulanate
3. cefidinir
4. clindamycin
Term
How do you treat ABRS in adults?
Definition
1. high dose amoxicillin or amoxicillin/clavulanate
2. cefpodoxine
3. moxifloxacin
4. clarithromycin
Term
Are nasal steroids useful in ABRS?
Definition
No, they act too slowly
Term
What is the first line of therapy for ABRS?
Definition
amoxicillin
Term
If a patient is allergic to penicillins, what do you use to treat ABRS?
Definition
trimethoprim/sulfamethoxazole or a macrolide
Term
If a patient has used abx in the last 4-6 weeks, what do you use to treat ABRS?
Definition
1. fluoroquinolone
2. high dose amoxicillin/clavulanate
Term
What % of children 5-9 years with sore throat have GABHS?
Definition
30%
Term
What % of 10-19 years with sore throat have GABHS?
Definition
15-20%
Term
What % of adults with sore throat have GABHS?
Definition
5-10%
Term
What is included in the diagnostic point system for GABHS pharyngitis?
Definition
1. Tonsilar exudates
2. absence of cough
3. tender anterior cervical lymph nodes
4. history of fever >100.4
5. <15 years
6. >45 years
Term
What is an uncommon, but very specific, finding for the diagnosis of GABHS pharyngitis?
Definition
1. scarlatiniform rash (sandpaper rash)
2. palatine petechiae?
Term
What should be avoided with a GABHS pharyngitis?
Definition
NSAIDs - may increase the risk of necrotizing fasciitis or toxic shock syndrome
Term
What is magic mouthwash?
Definition
a mixture of drugs (anesthetics and others) that help relieve the symptoms of pharyngitis
Term
What is the DOC for GABHS pharyngitis?
Definition
1. penicillin G bezathine IM
2. Penicillin VK in adults
3. Macrolide for penicillin allergy - clarithromycin
Term
What type of drug is guaifenesin?
Definition
expectorant (for cough)
Term
What type of drug is dextromethorphan?
Definition
cough suppressant
Term
What might you use to treat watery, itchy eyes?
Definition
olopatadine
azelastine

both are antihistamine and mast cell stabilizers
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