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Pharm Unit 4
unit4
39
Medical
Professional
12/03/2011

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Term
Niacin
Definition
best for increasing HDL
(1) lowers TG synthesis
(2) decreased lipolysis in adipose tissue (decreased FFA)
(3) reduced hepatic clearance of HDL
Term
Clofibrate
Definition
Fibrate (1st); marked reduction in VLDL
(1) LPL synthesis (clearance of TG-rich lipoproteins)
(2) inhibition of apoC III expression (enhance VLDL clearance)
-GALLSTONES
Term
Gemfibrozil
Definition
Fibrate; marked reduction in VLDL
Term
Fenofibrate
Definition
Fibrate; marked reduction in VLDL
Term
Ciprofibrate
Definition
Fibrate; marked reduction in VLDL
Term
Benzfibrate
Definition
Fibrate; marked reduction in VLDL
Term
Cholestyramine
Definition
Bile Acid Sequestrants (binds negatively charged bile acids)
-reduces LDL; slight increase in TG and HDL
-COMBO w/ statins
Term
Colestipol
Definition
Bile Acid Sequestrants (binds negatively charged bile acids)
-reduces LDL; slight increase in TG and HDL
-COMBO w/ statins
Term
Colesevelam
Definition
Bile Acid Sequestrants (binds negatively charged bile acids)
-reduces LDL; slight increase in TG and HDL
-COMBO w/ statins
Term
Mevastatin
Definition
HMG-CoA reductase inhibitor (statins)
-1st one studied
Term
Iovastatin
Definition
HMG-CoA reductase inhibitor (statins)
-1st approved by FDA
Term
simvastatin
Definition
HMG-CoA reductase inhibitor (statins)
Term
pravastatin
Definition
HMG-CoA reductase inhibitor (statins)
Term
fluvastatin
Definition
HMG-CoA reductase inhibitor (statins)
Term
astrovastatin
Definition
HMG-CoA reductase inhibitor (statins)
-longer t1/2 (lipitor)
Term
rosuvastatin
Definition
HMG-CoA reductase inhibitor (statins)
-longer t1/2 (crestor)
Term
Ezetimbe
Definition
inhibits enterocyte abs. of cholesterol in intestine
-new drug (best in combo w/ statins)
Term
thiazides
Definition
weak diuretics, lower BP, improve symptoms of congestion
Term
furosemide
Definition
loop/strong diuretic
Term
amiloride, spironolactone
Definition
potassium sparing diuretics (reduce K+ depletion)
Term
methyl dopa
Definition
Central sympathetic drug, alpha 2 agonist (pregnancy)
Term
Clonidine
Definition
central sympathetic, alpha 2 agonist, used when traditional means to control BP fails
Term
Guanethidine
Definition
adrenergic neuron blocking agent
Term
Reserpine
Definition
adrenergic neuron blocking agent
Term
Propanolol
Definition
adrenergic beta receptor blocker (non-selective)
Term
Metoprolol
Definition
adrenergic beta receptor blocker (B1 selective)
Term
Antenolol
Definition
adrenergic beta receptor blocker (B1 selective)
Term
Cravedilol
Definition
adrenergic beta receptor blocker (non-selective)
-also alpha-1 blocker
Term
Bisoprolol
Definition
adrenergic beat receptor blocker (B1 selective)
Term
Adrenergic alpha receptor blockers
Definition
blocks alpha 1; given at bed to avoid orthostatic effect
Term
Hydrazaline
Definition
direct vasodilator (use w/ beta-blocker)
-short t1/2; lupus-like syndrome
-NO release
Term
Sodium Nitroprusside
Definition
direct vasodilator (use w/ beta-blocker)
-NO release
-avoid prolonged use in renal failure (CN build-up)
Term
Minoxidil
Definition
direct vasodilator (use w/ beta-blocker)
-hyperpolarize SM (opening K channels)
Term
Amilodipine (felodipine. isradipine)
Definition
Calcium channel blocker (vasoselective = dihydropyridines)
Term
Nifedipine
Definition
Calcium channel blocker (vasoselective = dihydropyridines)
Term
Verapamil
Definition
Calcium channel blocker (nondihydropyridines)
Term
Diltiazem
Definition
Calcium channel blockers (nondihydropyridines)
Term
(end w/ pril) captopril, enalapril, lisinopril, ramipril, quinapril, fosinopril
Definition
ACE inhibitor
Term
(end in -sartan) losartan, irbesartan, valsartan, candesartan, olmesartan, telmisartan
Definition
Angiotensin receptor blocker
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