Term
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Definition
Monoclonal antibody to fibrin receptor (glycoprotein IIb/IIIa) on platelets. Used to prevent
clotting after coronary angioplasty |
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Term
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Definition
Antipyretic analgesic: very weak cyclooxygenase inhibitor; not anti−inflammatory. Less
toxic than aspirin but more dangerous in overdose (causes hepatic necrosis−antidote:
acetylcysteine) |
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Term
| Acetazolamide, dorzolamide |
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Definition
Carbonic anhydrase inhibitor diuretic: produces a NaHCO3 diuresis, results in bicarbonate
depletion, and therefore has self−limited action. Used in glaucoma and mountain sickness.
Dorzolamide is a topical analog for glaucoma |
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Term
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Definition
Cholinomimetic prototype: transmitter in CNS, ENS, all ANS ganglia, parasympathetic
postganglionic synapses, sympathetic postganglionic fibers to sweat glands, and some
skeletal muscle vasodilator synapses |
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Term
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Definition
Antiviral: guanosine analog - inhibits DNA synthesis in herpes simplex and varicella zoster. Requires
activation by viral thymidine kinase (TK− strains are resistant). Tox: behavioral effects and
nephrotoxicity (crystalluria), but not myelosuppression |
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Term
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Definition
| Antiarrhythmic: Hyperpolarizes AV nodal tissue- decreases conduction velocity (blocks conduction for 10−15 sec.) Used for supraventricular tachicardia and nodal reentry arrhythmias. (parenteral only) |
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Term
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Definition
| Antigout: inhibitor of xanthine oxidase; reduces production of uric acid |
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Term
Albuterol, metaproterenol,
terbutaline, salmeterenol |
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Definition
| Important β2−agonists; used mainly for asthma. |
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Term
Alprazolam indication, toxicity, pneumonic |
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Definition
Benzodiazepine sedative−hypnotic: widely used in anxiety states, selectivity for panic
attacks and phobias; possible antidepressant actions. Tox: psychologic and physical
dependence, additive effects with other CNS depressants pneumonic: "Al prays when he is in fear" |
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Term
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Definition
Thrombolytic: human recombinant tissue plasminogen activator. Used in acute MI to
recanalize the occluded coronary. Occasionally used in pulmonary embolism, stroke. Tox:
bleeding |
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Term
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Definition
| K+−sparing diuretic: blocks Na+ channels in cortical collecting tubules (distal tubule). Can be used in hyperaldosteronism. |
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Term
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Definition
| Antineoplastic (breast CA, cushings): Aromatase inhibitor and p-450 inhibitor. Reduces conversion of cholesterol to the hormone precursor, pregnenolone. |
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Term
Acarbose indications, side effects, pneumonic |
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Definition
indications: type II diabetes. Inhibits alpha-glucosidase; delays absorption from gut side effects: flatuloence pneumonic: "carbon is a gas and acarbo- causes gas" |
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Term
| Aspirin (acetylsalicylic acid) |
|
Definition
indications:NSAID prototype: inhibits cyclooxygenase (COX) I and II irreversibly. Potent antiplatelet
agent as well as antipyretic analgesic anti−inflammatory drug side effects: contraindicated for children with flue or chicken pox (leads to Reye syndrome) |
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Term
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Definition
biphosphonate - inhibits osteoclasts
Used for hypercalcemia of malignancy, Paget disease, osteoporosis, hyperparathyroidism. |
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Term
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Definition
| PGE1 Agonist. Used for impotency and maintaining open PDA |
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Term
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Definition
cytoprotective. coats gastric ulcers and raised pH. indications: PUD, diarrhea (causes constipation) |
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Term
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Definition
Antiviral-inhibits uncoating influenza A (not B) Antiparkinsonia-increases release of DA |
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Term
Aminoglycosides (Gentamycin, Neomycin, Streptomycin) |
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Definition
Antibiotic-bacteriostatic and -cidal depending on concentrations. Binds to 30s subunit. Indications: broad G+ and G-. Good for bone infections. Toxicity: Oto, renal, neuromuscular blockade |
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