Term
| Calcium channels role in muscle contraction and SNS relationship |
|
Definition
- Cardiac and smooth muscle depolarization happens from increase in Ca
- Control of Ca ch opening is by beta1-adrenergic receptors being stimulated by the SNS |
|
|
Term
|
Definition
- Dilate vascular smooth muscle, reduce BP
- Reduce heart O2 demand: dilate coronary arteries, reduce contractility
- Slow speed of electrical conduction = lower HR |
|
|
Term
|
Definition
Dihydropyrinidines
Nondihydropyrinidines |
|
|
Term
|
Definition
- Absorbed well PO
- Protein bound, excreted by liver, extensive first pass
- Highly selective for channels in vascular smooth muscle, at high doses lose selectivity and affect Ca ch in heart |
|
|
Term
| Adverse effects of dihydropyrinidines |
|
Definition
Flushed skin
Headache
Dizziness
Peripheral edema
Lightheadedness
Nausea
Diarrhea |
|
|
Term
| Prototype drug of dihydropyrinidines |
|
Definition
Nifedipine (Adalat CC, Procardia XL)
HTN |
|
|
Term
|
Definition
- Block calcium channels in vascular smooth muscle and in myocardium
- Results in reduction in contractility, decreased HR |
|
|
Term
| Adverse effects of nondihydropyrinidines |
|
Definition
Constipation
Flushed skin
Headache
Dizziness
Edema of ankles and feet
Lightheadedness
Gingival hyperplasia |
|
|
Term
| Prototype drug of nondihydropyrinidines |
|
Definition
Verapamil (Calan, Isoptin, Verelan)
Antihypertensive, antianginal, antidysrhythmic |
|
|
