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Pharm test 2 of semester 2
fmlll
130
Health Care
Graduate
03/18/2013

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Cards

Term
Methylphenidate
Definition
Stimulant
Term
Dexymethylphenidate
Definition
Stimulant
Term
Dextroamphetamine
Definition
Stimulant- mixed amphetamine salt
Term
Amphetamine
Definition
Stimulant- mixed amphetamine salt
Term
Lisdexamfetamine
Definition
Stimulant- mixed amphetamine salt
Term
Atomoxetine
Definition
Selective nor-epinephrine reuptake inhibitor
Non-stimulant

Good for ADHD, slower onset of efficacy
Term
Clonidine
Definition
Alpha2 agonist for ADHD

Kids who cant tolerate stimulants, have tics, or more sever ADHD. Give at night, sedating.
Term
Guanfacine
Definition
Alpha2 agonist for ADHD

Kids who cant tolerate stimulants, have tics, or more sever ADHD. Give at night, sedating.
Term
Chlorpromazine
Definition
1st Gen Phenothiazine antipsychotic
Term
Trifluoperazine
Definition
1st Gen Phenothiazine antipsychotic
Term
Thioridazine
Definition
1st Gen Phenothiazine antipsychotic
Term
Fluphenazine
Definition
1st Gen Phenothiazine antipsychotic
Term
Perphenazine
Definition
1st Gen Phenothiazine antipsychotic
Term
Mesoridazine
Definition
1st Gen Phenothiazine antipsychotic
Term
Haloperidol
Definition
Butyropenone

1st gen antipsychotic
Term
Aripiprazole
Definition
2nd gen antipsychotic, atypical
Term
Asenapine
Definition
2nd gen antipsychotic, atypical
Term
Clozapine
Definition
2nd gen antipsychotic, atypical
Term
Iloperidone
Definition
2nd gen antipsychotic, atypical
Term
Lurasidone
Definition
2nd gen antipsychotic, atypical
Term
Olanzapine
Definition
2nd gen antipsychotic, atypical
Term
Palperidone
Definition
2nd gen antipsychotic, atypical
Term
Quetiapine
Definition
2nd gen antipsychotic, atypical
Term
Risperidone
Definition
2nd gen antipsychotic, atypical
Term
Ziprasidone
Definition
2nd gen antipsychotic, atypical
Term
Dantrolene
Definition
Neuroleptic Malignant Syndrome
Muscle relaxant
Term
Imipramine
Definition
TCA antidepressent tertiary amine
Term
Amitriptyline
Definition
TCA antidepressent tertiary amine
Term
Desipramine
Definition
TCA- secondary amine
Term
Nortriptyline
Definition
TCA- secondary amine
Term
Selegiline
Definition
Patch form, MAO inhibitor
Term
Trazadone
Definition
Heterocyclic antidepressent

Serotonin reuptake inhibitor
Good sleep aid for elderly!
No dependence

Priapism!!
Term
Bupropion
Definition
Heterocyclic antidepressent

Weak reuptake inhibitor of NE and dopamine
Most appropriate antidepressant for BPD
No sexual side effects like Trazadone

Seizure risk
Also used for smoking cessation
Term
Fluoxetine
Definition
SSRI antidepressant

Bulimia
Term
Sertraline
Definition
SSRI antidepressant

SAD
Term
Fluvoxamine
Definition
SSRI antidepressant
Only for OCD
Term
Paroxetine
Definition
SSRI antidepressant

Good antidepressant for BPD

Short T1/2, more likely to have SSRI withdrawal
Term
Citalopram
Definition
SSRI antidepressant

Only for depression
Term
Escitalopram
Definition
SSRI antidepressant

Only for depression
Term
Mirtazapine
Definition
Receptor modulator antidepressant

Sedative! Good for coexisting depression

Causes weight gain
Term
Nefazadone
Definition
Receptor modulator antidepressant

Also cures sexual dysfunction in SSRI therapy
No weight gain
Term
Venlafaxine
Definition
Dual reuptake inhibitor
Term
Duloxetine
Definition
Dual reuptake inhibitor
Term
Desvenlafaxine
Definition
Dual reuptake inhibitor
Term
Milnacipran
Definition
Dual reuptake inhibitor

Fibromyalgia
Term
Vilazodone
Definition
Dual-acting seroterngic, SRI plus partial 5HT agonist

Depression
More GI, less sexual side effects
Term
Lispro
Definition
Rapid acting insulin
Term
Aspart
Definition
Rapid acting insulin
Term
Glulisine
Definition
Rapid acting insulin
Term
Regular insulin
Definition
Short acting
Term
NPH
Definition
Intermediate acting
Term
Glargine
Definition
Long acting
Term
Detemir
Definition
Long acting
Term
Metformin
Definition
Biguanides

Inhibit gluconeogenesis, increase glucose uptake

Hold drug 48 hrs if using radio contrast

Lactic acidosis! other GI effects too
Term
Chlorpropamide
Definition
1st gen sulfonylrea

Stimulate insulin release
Term
Glipizide
Definition
2nd gen sulfonylrea
Short half life, good in elderly
Stimulate insulin release
Take 30 min before meals

Lose effectiveness after 1-2 years
Caution in sulfa allergies
Term
Glyburide
Definition
2nd gen sulfonylrea
Stimulate insulin release
Take 30 min before meals


Lose effectiveness after 1-2 years
Caution in sulfa allergies
Term
Glimeripide
Definition
2nd gen sulfonylrea
Stimulate insulin release
Take 30 min before meals


Lose effectiveness after 1-2 years
Caution in sulfa allergies
Term
Repaglinide
Definition
Meglitinides
Stimulate insulin release

Take 30 min before meals
Don't use with insulin or sulfonylureas
May cause liver dysfunction
Term
Nateglinide
Definition
Meglitinides
Stimulate insulin release

Take 30 min before meals
Don't use with insulin or sulfonylureas
May cause liver dysfunction
Term
Pioglitazone
Definition
Thiazolidinediones
Reduce insulin resistance

Weight gain, edema, fluid retention
Monitor for CHF
Term
Rosiglitazone
Definition
Thiazolidinediones
Reduce insulin resistance

Weight gain, edema, fluid retention
MI risk!
Monitor for CHF
Term
Acarbose
Definition
alpha glucosidase inhibitor
Slows absorption of carbs

GI SE's
Term
Miglitol
Definition
alpha glucosidase inhibitor
Slows absorption of carbs

GI SE's
Term
Alaprazolam
Definition
BDZ

Intermediate T1/2- chronic or acute anxiety (xanax)
Term
Diazepam
Definition
BDZ

Long T1/2- chronic anxiety (Valium)
Seizure disorders

Also one of the best muscle relaxants

Use for EtOH withdrawal (Or chlordiazepoxide)
Term
Clonazepam
Definition
BDZ

Long T1/2- chronic anxiety
Seizure disorders
Term
Lorazepam
Definition
BDZ

Short T1/2- acute anxiety
DOC for epilepticus!
Term
Temazepam
Definition
BDZ

Intermediate acting
Best choice BDZ for insomnia
Term
Flurazepam
Definition
BDZ

Long acting
For insomnia, may cause daytime sluggishness
Term
Triazolam
Definition
BDZ

Short acting
For insomnia, may cause early waking and daytime anxiety
Term
Midazolam
Definition
BDZ

Anesthesia, very short onset and peak
Term
Chlorodiazepoxide
Definition
BDZ

Know generic name (Librium)

Use for EtOH withdrawl, or Diazepam
Term
Zolpidem
Definition
BDZ receptor agonist

For insomnia, may cause sleepwalking
Term
Zaleplon
Definition
BDZ receptor agonist

For insomnia, may cause sleepwalking
Term
Eszopiclone
Definition
BDZ receptor agonist

ONLY drug indicated for long term insomnia
For insomnia, may cause sleepwalking
Term
Melatonin
Definition
Melatonin agonist
Term
Ramelteon
Definition
Selective melatonin agonist

Treat insomnia characterized by difficulty falling asleep
Term
Phenobarbital
Definition
Barbiturate

Ultra long acting
CYP450 substrate and inducer
Term
Thiopental
Definition
Barbiturate

Ultra short acting
CYP450 substrate and inducer
Term
Chloral Hydrate
Definition
Misc sedative
Term
Hydroxyzine
Definition
Misc sedative
Antihistamine- anticholinergic properties

Not indicated for insomnia, for anxiety/pruritis or sedation pre/post surgery
Term
Diphenhydramine
Definition
Misc sedative
Antihistamine- anticholinergic properties
Term
Doxylamine
Definition
Misc sedative
Antihistamine- anticholinergic properties
Term
Doxepin
Definition
Misc sedative
Antidepressant
Term
Propanolol
Definition
Beta blocker
Sedative for performance anxiety
Term
Quetiapine
Definition
Antipsychotic for sedation
Term
Busipirone
Definition
Non BDZ, good for GAD
Term
Valproic Acid
Definition
Anticonvulsant for BPD
First line treatment of mania

MOA is up to 14 days

Inhibits P450

May cause weight loss and GI upset
Term
Lamotrigine
Definition
Best tolerated anticonvulsant
For BPD
Less effective than Valproic acid
Term
Levothyroxine
Definition
Synthroid
Levoxyl
Levothroid

Start at 100-125mcg qd and increase by 25 mcg

Take on an empty stomach
Term
Liothyronine
Definition
T3
Rarely used, doesnt increase T4 levels
Term
Liotrix
Definition
T4:T3 is 4:1 mixed ratio
Term
TRH and TSH
Definition
synthetically produced, come in IV
Term
Propylthiouracil (PTU)
Definition
Thiourea for hyperthyroidism

TOC FOR Pregnant Grave's disease

Block catalized iodination and conversion of T3 to T4

Rash, hepatotoxic, agranulocytosis
CYP450 inhibitor (increases anticoagulation of coumadin)
Term
Methimazole
Definition
Thiourea for hyperthyroidism

Block catalized iodination and conversion of T3 to T4

Rash, hepatotoxic, agranulocytosis
CYP450 inhibitor (increases anticoagulation of coumadin)
Term
THiocyante and perchlorate ions
Definition
Block uptake of iodine

Ionic inhibitors
Ex) Cabbage, cigarettes...
Term
Iodide salts
Definition
Short term for thyrotoxicosis

Prepare pts for surgery or after RAI
Term
RAI
Definition
lots of fluids and sleep alone
Term
Lithium
Definition
mood stabilizer for BPD

Contraindicated in breast feeding
Heart defects in baby

May cause hypothyroidism and Sodium depletion
Term
stimulants contraindicated in
Definition
CVD, glucoma, hyperthyroidism, epilepsy etc.
Term
Flumazenil
Definition
Antidote for BDZ

Normally wide therapeutic index in BDZs
Term
MOA for TCAs
Definition
Block reuptake of NE and 5-HT

Narrow therapeutic index
Term
TCA adverse effects
Definition
Cholinergic, Histaminic, Alpa-1 blockade

ANti-sludge, sedation/weight gain, OH and sexual dysfunction
Term
St. Johns Wort
Definition
Used for depression
Term
Atypical Antipsychotics side effects
Definition
Less EPS, more metabolic (dyslipidemia, weight gain, diabetes)
Term
Side effects of all antipsychotics
Definition
Muscarinic antagonism, a1 antagonism (OH), histamine antagonism (sedation)
Term
Tardiv Dyskinesia
Definition
Chronic EPS
Takes 6 months or so of therapy
Term
Cosyntropin
Definition
ACTH
AKA Corticotropin

Diagnostic to distinguish between addisons and secondary insufficiency
Term
Corticotropin
Definition
Marketed as Cosyntropin

AKA ACTH
Term
Somatotropin
Definition
AKA GH
Inhibited by somatostatin

Can decrease insulin sensitivity, leads to DM
Term
Octreotide
Definition
GHIH
Suppresses GH and TSH

Used for secretory diarrhea caused by VIPomas
Term
Bromocriptine
Definition
D2 agonist
Remember D2 agonists decrease prolactin
Term
Pitocin
Definition
Oxytocin
To induce labor, reduce post-partum bleeding
Nasal spray for milk production
Term
Vasopressin
Definition
ADA ADH
Used for diabetes insipid us
Term
Desmopressin (DDAVP)
Definition
decreases V1 receptor binding
Term
Humulin
Definition
Human insulin made from E.Coli
Term
Novolin
Definition
Human insulin with insertion of amino acids
Term
Incretin Mimetic agents
Definition
Promote insulin release

Used as adjunct

Can cause pancreatitis!
Term
Exanatide
Definition
Promote insulin release (possible hypoglycemia)
Incretin mimetic

Used as adjunct

Can cause pancreatitis!
Term
Liraglutide
Definition
Promote insulin release (possible hypoglycemia)
Incretin mimetic

Used as adjunct

Can cause pancreatitis!
Term
Pramlintide
Definition
Human amylin analog

Adjunct for diabetics who fail to control glucose!
Potential hypoglycemia
Term
Sitagliptan
Definition
Block DPP-4 enzyme, enhance incretin system

Adjunct to diet and exercise in DM2
May cause rash, pruritus. Less effect on HbA1C

Low risk of hypoglycemia
Term
Saxagliptan
Definition
Block DPP-4 enzyme, enhance incretin system

Adjunct to diet and exercise in DM2
May cause rash, pruritus. Less effect on HbA1C

Low risk of hypoglycemia
Term
Cyclobenzaprine
Definition
Non BDZ skeletal muscle relaxant
Term
Clozapine and olanzapine
Definition
Have the most metabolic side effects of 2nd gen antipsychotics

Clozapine has significant hematologic effects
Term
CYP450 Generalized
Definition
Antidepressants like SSRIs are usually Inhibitors
Benzos and BDZ agonists are usually substrates
Barbituates are usually inducers
Term
Dual reuptake cautions
Definition
HTN, renal, liver, MI...
Term
Treatment for Dystonias and akathisia
Definition
Dystonia- anticholinergics (Benztropine, trihexphenidyl, diphenhydramine...

Akathisia- beta blockers or BDZ
Term
BDZ and Barbituate effects on GABA
Definition
BDZ potentiate GABA

Barbituates prolong GABA (irreversible)
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