Term
True or False:
Antiseizure meds can be used with birth control |
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Definition
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Term
| No abrupt withdrawal of antiseizure meds- Must wean off over ___ to ___ weeks. |
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Definition
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Term
| Fact: Many antiseizure meds have therapeutic levels! |
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Definition
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Term
| Antiseizure meds depress the ___. |
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Definition
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Term
Antiseizure MOA: (Benzos, Barbiturates)
Increase ___ ion influx into GABA molecules = ___ effect. |
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Definition
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Term
Antiseizure MOA: (Hydantoin, Phenytoin)
Stop __ and __ ions = ___ effect. |
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Definition
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Term
| GABA is an _____ neurotransmitter. |
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Definition
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Term
| Name 3 drug categories that potentiate (increase the effect of; 'potent') GABA: |
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Definition
Barbiturates (Phenobarb)
Miscellaneous
Benzodiazepines |
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Term
| Barbiturates (Phenobarbitol) have a therapeutic range of ___ to ___ mcg/mL |
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Definition
15-40 mcg/mL
Bar(Bit**)urates are 15-40 years old! |
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Term
| Phenobarb causes severe CNS _____. |
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Definition
Depression
Barbi***urates tend to be 'depressed' people |
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Term
| Phenobarb can lead to deficiencies of vitamins __, __, and __ __. |
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Definition
D, K, Folic acid
Get out in the sun a lot
Green leafy veggies |
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Term
| Barbiturates (Phenobarb) are metabolized where? |
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Definition
| Liver; monitor carefully in hepatic impairment |
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Term
| Name 5 Miscellaneous drugs (that increase GABA): |
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Definition
1. Gabapentin (Neurontin)
2. Tiagebine (Gabitril)
3. Lamotrigine (Lamictal)
4. Levetiracetam (Keppra)
5. Topirmate (Topamax)
Gaba, Let's Keep Talking Now! |
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Term
| Fact: Miscellaneous antiseizure meds have an unknown MOA. |
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Definition
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Term
| What 4 things would a nurse monitor for in a patient taking Miscellaneous antiseizure meds? |
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Definition
1. Daytime somnolence
2. Ataxia
3. Dizziness
4. Fatigue |
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Term
Topamax is a ___ drug.
It helps with ___.
Name 2 side effects of Topamax. |
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Definition
Miscellaneous
Migraines
1. Weight loss
2. Memory difficulty |
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Term
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Definition
1. Ativan (Lorazepam)
2. Valium
3. Xanax
4. Clonapin |
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Term
| Benzo's have a HRF ___ and should only be used __ __. |
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Definition
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Term
| ____ are the drug of choice for status epilepticus. |
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Definition
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Term
| Benzos should NOT be used with other ___ ___. Benzos increase the levels of ___. |
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Definition
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Term
Benzos might cause Dig toxicity. Early signs of Dig toxicity are ___ and ___.
The therapeutic range for Dig is ___ to ___ nmol/l |
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Definition
Nausea and vomiting
1-2.5 nmol/l |
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Term
| ___ and ___-like drugs suppress __+. |
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Definition
Hydantoin and Phenytoin-like
Suppress Na+ |
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Term
| Hydantoin/phenytoin-like drugs ____ neuronal Na channels in order to ____ neuron activity. |
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Definition
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Term
True or False?
Hydantoin and Phenytoin-like drugs completely block Na channels. |
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Definition
FALSE
If Na channels were completely blocked, it'd be an anesthetic. |
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Term
| What are the most used antiseizure meds? |
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Definition
| Hydantoin and Phenytoin-like drugs |
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Term
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Definition
1. Phenytoin (Dilantin)
2. Fosphenytoin (Cerebyx) |
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Term
| Name 3 Phenytoin-like drugs: |
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Definition
1. Carbamazepine (Tegretol)
2. Valproic acid (Depakote)
3. Zonisamide (Zonegran) |
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Term
| The therapeutic range for Dilantin is __ to __ mcg/mL. |
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Definition
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Term
Dilantin can only be administered with __, or else it may precipate/extravasate.
The max IVF Dilantin rate is __. |
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Definition
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Term
| __ Dilantin will cause tissue damage. |
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Definition
IM
"Ouch! IM going to DIe(lantin)!! |
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Term
| What 2 things might Dilantin cause in the heart? |
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Definition
1. Dysrhythmias
2. Bradycardia
Your HEART SLOWS down when you're about to DIe(lantin). |
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Term
| Dilantin interferes with 'packaging' of __ and __, causing deficits in both. |
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Definition
Vitamin D- eat dairy, fish, get sun; helps Ca absorb
Vitamin K- green leafy veggies; helps blood clot |
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Term
| Valproic Acid (Depakene, Depakote) has a therapeutic level of ___ to ___ mcg/mL. |
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Definition
50-125 mcg/mL
Val'Pro'ic 50-125 yo ppl are 'pro's' at life. |
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Term
| Valproic acid can cause fatal _____. |
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Definition
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Term
| Valproic levels > 100 mcg/mL can cause ___. |
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Definition
Thrombocytopenia
I looked at the VALley and said, "BOy, CYTE(sight)!" |
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Term
| Do not __ or __ Valproic; may cause serious GI irritation. |
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Definition
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Term
| Do NOT serve Valproic acid with __ __! |
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Definition
Carbonated beverages
2 acids can't go together! :) |
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Term
| The therapeutic range of Carbamazepine (Tegretol) is __ to __ mcg/mL. |
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Definition
4-12 mcg/mL
Only kids 4-12 are allowed in the MAZE!(carbaMAZEpine) |
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Term
Carbamazepine (Tegretol) may cause ___ and ___.
S/S of each? |
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Definition
Aplastic anemia: Bleed, bruise
Agranulocytosis: Low grade fever, cough |
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Term
| Carbamazepine (Tegretol) may only be administered __. |
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Definition
PO
A no-CARB(amazepine) diet makes me so PO'd! |
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Term
| 4 S/S of hydantoin/phenytoin toxicity? |
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Definition
Dizziness
Ataxia
Diplopia
Lethargy
Mr. FEENY(Pheny), Topanga is HIGH(Hy)!
(Pheny/Hydantoin give s/s that a high person would have) |
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Term
| Hyndantoin and Pheytoin-like drugs have multiple drug-drug/food interactions. They may affect __ metabolism. They may also cause ___. |
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Definition
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Term
| Hydantoin and Phenytoin-like drugs increase the effects of ___. |
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Definition
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Term
| ___ increases serum levels of Dilantin. |
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Definition
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Term
| GABA is an ____ neurotransmitter, so these drugs ___ its effects (or stop it from being blocked) in order to stop seizures! |
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Definition
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Term
| Barbiturates can be given __, __, or __. |
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Definition
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