Term
Warfarin:
Type of drug?
Treats what, and why? |
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Definition
an anti-coagulant, blood thinner
treats atrial fibrillation, because this condition creates thombi in heart |
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Term
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Definition
| drug that becomes active at some point |
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Term
| Major sites for biotransformation |
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Definition
Liver
pre-hepatic small intestine |
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Term
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Definition
international normalized ratio
-a measure of clotting time |
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Definition
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Definition
| extended erection (4 hr+) |
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Term
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Definition
alpha-1 adrenergix blocker
causes vasodilation, lower BP |
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Term
| zolendronic acid is harmful to the dentition in what way? |
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Definition
it's a bisphosphonate taken for bone cancers
it causes osteonecrosis of the jaw |
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Term
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Definition
Muscarinic Cholinergic Receptor Antagonist
(anti-parasympathetic) |
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Term
| metronidazole is harmful when drinking alcohol because |
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Definition
| it blocks acetaldehyde dehydrogenase |
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Term
| epinephrine stimulates which receptors and causes what in each of them? |
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Definition
alpha-1 vasoconstriction
beta-1 increased HR
beta 2- vasodilation |
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Term
| what would happen if a patient was given both epinephrine and propranolol |
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Definition
increased heart rate
-prop. is a beta blocker, so the alpha effects of epi would go unopposed |
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Term
| 2-diethylamino 2,6 acetoxylide |
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Definition
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Term
| n-acetyl para amino phenol |
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Definition
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Term
| european name for acetominophen |
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Definition
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Term
| which phase of clinical trials is conducted on people with the disease? |
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Definition
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Term
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Definition
vioxx- selective cox-2 inhibitor
caused stokes, and MI |
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Term
| anti-cancer drugs would fall into which pregnancy category? |
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Definition
| D- risk, but benefits outweigh the risk |
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Term
| what is advised pregnant women taking ibuprofen |
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Definition
It is alright during 1st + 2nd trimesters (B)
3rd trimester it increases bleeding risk, causes premature closing of ductus arteriosus (D) |
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Term
| how can drugs be modified to slow their absorption in stomach? |
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Definition
| wrap them in enteric coat |
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Term
| what is true of an acid at its pKa |
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Definition
| 50% of the species are charged |
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Term
| what is the 1st pass effect? |
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Definition
| inactivation of drugs by liver enzymes |
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Term
| what effect do fats have on gastric emptying |
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Definition
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Term
| a fat soluble drug named in class... |
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Definition
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Term
| what occurs to acetaminophen in the liver |
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Definition
| it is inactivated by glucronic acid |
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Term
| what toxic substance is acetaminophen converted to, and how is it dealt with? |
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Definition
5% is converted to NAPQI in sm. intestine
BUT it is inactivated by glutathione |
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Term
| how would an enzyme inhibitor affect drug levels? |
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Definition
| it would elevate them, as it inactivated the enzyme responsible for the drug's metabolism.. |
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Term
| a K3 of 1 is characteristic of what.. |
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Definition
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Definition
beta 2 agonist, uterine smooth muscle
reduces contractions |
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Term
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Definition
reduces IOP in glaucoma
pro-drug of epi |
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Term
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Definition
alpha 2 agonist
lowers outflow of NT
hypotension, sedation, analgesia |
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Term
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Definition
beta 1 agonist
increases stroke force, heart failure treatment |
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Term
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Definition
beta 2 agonist
-smooth muscle relaxant (vasodilates mm) |
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Term
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Definition
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Term
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Definition
activates alpha and beta
indirectly causes release of NE |
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Term
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Definition
| weight loss, CNS stimulant, anorexant |
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Term
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Definition
controls HTN associated with pheochromocytoma
non-selective alpha agonust |
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Term
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Definition
| selective alpha blocker, HTN drug |
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Term
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Definition
| alpha 2 blocker (so more NE released) |
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Definition
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Definition
| prevents ulcers from nsaids, INDUCES labor |
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Term
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Definition
increased uric acid excretion
prevents penicillin excretion |
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Term
| drug that reverses effects of atropoine and scopolamine |
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Definition
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Term
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Definition
physostigmine, neostigmine
(anticholinesterase inhibitors) |
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Term
| ganglionic blockers: depolarizing vs polarizing |
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Definition
depolarizing- dominant organ dominates (nicotine)
non-depolarizing- non-dom organ dominates |
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