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Pharm Spring Block II Side Effects/Contraindications
n/a
208
Pharmacology
Graduate
04/03/2013

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Cards

Term
What are the side effects of benzodiazepines?
Definition
Sedation, cognitive and psychomotor impairment
Interacts with alcohol
Discontinuation-related difficulties
Potential for abuse in predisposed individuals
Not effective for comorbid depression
Term
What is a potentially severe and dangerous side effect of giving benzodiazepines via IV?
Definition
Respiratory depression
Term
Why are benzodiazepines contraindicated in pregnancy and nursing?
Definition
Birth defects may occur if used in 1st trimester
Neonatal CNS depression and withdrawal if used near term
Term
Benzodiazepines should not be combined with what?
Definition
Alcohol or other CNS depressants
Term
What are the contraindications for morphine use?
Definition
Respiratory compromise, asthma, intracranial injuries (increased intracranial pressure), paralytic ileus
Term
What are the side effects of morphine?
Definition
Euphoria and dysphoria, respiratory depression, nausea, constipation, sedation, pruritus, urticaria, bronchospasms, urinary retention, anxiety, hypotension, miosis
Term
What are the CNS effects of morphine?
Definition
Analgesia (most effective for visceral pain), euphoria, sedation, cough suppression**, respiratory depression, miosis, nausea/emesis, physical and psychological dependence, tolerance
Term
What are the cardiovascular effects of morphine?
Definition
Vasodilation, decreases blood pressure, some negative inotropic response
Term
What are the pulmonary effects of morphine?
Definition
Bronchospasm
Term
What are the effects of morphine on the skin?
Definition
Histamine release to cause itchiness
Term
What are the effects of morphine on the GI?
Definition
Decreases secretions and motility of gut
Term
How does morphine effect smooth muscle?
Definition
Increases smooth muscle tone
Results in increased biliary tract contraction, detrusor muscle tone, urinary urgency, urinary retention, bronchoconstriction, reduced uterine tone prolonging labor, etc.
Term
What are the adverse effects of Meperidine?
Definition
Excess accumulation can cause seizures, avoid in renal patients
Term
Tramadol should be avoided alongside what drugs?
Definition
Antidepressants
Term
What are the adverse effects of TCAs?
Definition
Anticholinergic effects (blockade of muscarinic receptors)
Dry mouth, blurred vision, constipation, urinary retention, perspiration, orthostatic hypotension, sedation, seizures, conduction delays, weight gain
Term
What kind of drug interactions are there with TCAs?
Definition
Alcohol increases CNS depression
Anticholinergic agents
Insulin, oral hypoglycemic agents increase hypoglycemia
Monoamine oxidase inhibitors are toxic
Term
What are the adverse effects of SNRI use?
Definition
Dizziness, dry mouth, anorexia, somnolence, increased sweating, *nausea*
Possible serotonin syndrome
Hypertension in larger doses
Term
Duloxetine should be avoided in what patients?
Definition
Avoid in hepatic insufficiency or end-stage renal disease
Term
What are the adverse effects of MAO-inhibitors?
Definition
Orthostatic hypotension
Insomnia
Weight gain
Sexual dysfunction
Anticholinergic effects
Tyramine-induced hypertensive crisis
Term
What kind of drug interactions are there for MAO-inhibitors?
Definition
CNS stimulants can cause a hypertensive crisis
Any agent that would increase 5-HT levels may lead to serotonin syndrome
Term
What are the adverse effects of SSRIs?
Definition
Some tolerance, sexual dysfunction, headache
Akathesia (particularly with fluoxetine)
May induce a sudden switch to mania in vulnerable
Withdrawal
Term
What are potential drug interactions of SSRIs?
Definition
Can cause increased concentration of clozapine and may precipitate seizures
Should not be used with TCAs
Cautious use with lithium – may lead to seizures
Serotonin Syndrome (avoid with MAOIs)
Term
What are the manifestations of serotonin syndrome?
Definition
Akathisia-like restlessness, muscle twitches and myoclonus, hyperreflexia, sweating, shivering and tremor leading to seizures and coma
Term
What are the adverse effects of Bupropion?
Definition
Headache, nausea, dry mouth, insomnia, tremor, CNS effects due to DA
Should not be used with MAOIs – may cause hypertensive crisis
Term
What are the adverse effects of Nefazodone?
Definition
Strong inhibitor of CYP3A4
Significant interaction with triazolam, alprazolam
Term
What are the adverse effects of Mirtazapine?
Definition
Significant weight gain
Somnolence
Dry mouth
Constipation
Term
What are the adverse effects of lithium?
Definition
Low therapeutic index
Initially can cause polyuria or polydipsia, may induce nephrogenic diabetes insipidus
CV defects in pregnant, secreted in milk
Periodic concentration determination is crucial
Term
How do you prevent changes in in weight & depressed mood due to taking anti-epileptic drugs?
Definition
Inevitable with chronic use and adjusting dosage to minimize these side effects is not recommended since it can compromise anti-seizure efficacy
Term
How are anti-epileptics used in pregnant patients?
Definition
Almost all of the established antiepileptics have been reported to cause birth defects, but the majority of mothers on antiepileptic medication deliver normal infants
The fetus has a better prognosis when the pregnant woman is on a single AED vs a combination of AEDs
Term
The risk of hepatotoxicity with valproic acid is greatest in what patients?
Definition
Patients under 2 yrs & taking multiple medications
Fatal within 4 months
Term
What are the taratogenic effects of valproic acid?
Definition
Spina bifida
Cardiovascular defects
Malformation of digits
Term
What are the contraindications for the use of ethosuximide?
Definition
May exacerbate tonic-clonic seizures & complex partial seizures
Ineffective in management of psychomotor or major motor seizures
Term
What are the contraindications for the use of phenytoin?
Definition
Not useful in absence seizures
Term
What are the important pharmacokinetic characteristics of phenytoin?
Definition
Metabolism is saturable, if the dosing rate exceeds elimination capacity, the plasma levels of the drug quickly reach toxic levels
Term
What is the therapeutic index of phenytoin?
Definition
Very narrow
Therapeutic effects are seen at plasma concentration between 50-100 µmol/L
Adverse effects above 100 µmol/L
Term
What are the side effects of chronic phenytoin use?
Definition
Gingival hyperplasia especially in children & young adults
Hirsutism, coarsening features
Rash (hypersensitivity to hydantoins)
Hyperglycemia (inhibits insulin secretion)
Osteomalacia
Term
What are the taratogenic effects of phenytoin?
Definition
Cleft palate
Heart malformations
Hypoprothrombinemia and hemorrhage
Term
Concurrent administration with what drug should be avoided when taking Carbamezapine?
Definition
MAO-Is due to its similarity in structure to TCA's
Term
What are the side effects of Carbamezapine?
Definition
Antidiuretic effects and hyponatremia
Pregnancy category D, Teratogenic
Severe dermatological hypersensitivity reactions (rare)
Term
What kind of severe dermatological hypersensitivity reactions are associated with carbamezapine use? What causes this?
Definition
Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS)
Strongly associated with HLA-B1502 allele, much greater risk in asians
Term
What are the side effects of phenobarbital?
Definition
Drowsiness, Sedation, Habit-forming
Chronic treatment with high doses of causes behavioral problems in children
Agitation & confusion in adults
Over dose: Respiratory depression, CNS depression, coma, death
Term
Clorazepate is not used in what demographic?
Definition
Children under 9
Term
What are the side effects of Clonazepam and Clorazepate?
Definition
Behavioral disturbances in children; hyperactivity, irritability
Drowsiness, sedation, ataxia, insomnia
Overdose: Respiratory depression
Abrupt withdrawal can cause status epilepticus
Term
Felbamate has what black box warning?
Definition
Hepatotoxicity
Term
What are the problems associated with administration of Levodopa (L-DOPA) alone
Definition
Less than 1% of the dose reaches cerebral circulation due to degradation by AAD and MAO
Dopamine produced by peripheral conversion of L-DOPA produces side effects such as nausea, vomiting, cardiovascular effects
Term
What are the side effects of Carbidopa/Levodopa (Sinemet)?
Definition
Hypotension due to peripheral dopamine induced vasodilation
Cardiac arrhythmias, daytime sleepiness, schizophrenia
Mydriasis & acute increases in intraocular pressure (IOP)
Dyskinesia: Involuntary writhing movements
On/Off periods
Term
Carbidopa/Levodopa (Sinemet) is contraindicated in patients with what?
Definition
Psychosis
Narrow angle glaucoma
Peptic ulcer disease
Patients taking nonspecific inhibitors of MAO
Term
What are the consequences of long term L-Dopa therapy?
Definition
Tolerance and sensitization to the medication resulting in a “narrow therapeutic window”
Decreased buffer synaptic concentrations of dopamine
Altered the sensitivity to synaptic dopamine levels accentuating, responses to high (On) & low (off ) concentrations
Term
What are the disadvantages of dopamine receptor agonists compared to L-Dopa?
Definition
Hallucinations and hypotension are much more common
Term
Why is pergolide no longer used as a dopamine receptor agonist?
Definition
Long-term use associated with significant damage to cardiac valves. The drug has been removed from the market
Term
What are the side effects of ergot alkaloid non-specific dopamine receptor agonists?
Definition
Initial treatment causes profound hypotension
Often induce nausea and fatigue with initial treatment
Term
What are the side effects of Ropinirole and Pramipexole (selective dopamine receptor agonists)?
Definition
Hallucinations, Somnolence
Term
What are the side effect considerations of apomorphine? What should it be given alongside?
Definition
High potential to cause nausea & vomiting
Pretreatment with antiemetic trimethobenzamide
Term
Apomorphine should be avoided alongside what drugs?
Definition
Antiemetics that are 5HT3 antagonists (ex. ondansetron)
Causes significant hypotension and can lead to fainting episodes
Term
Inhibition of MAO-A retards breakdown of all central & peripheral catecholamines can lead to life threatening side effects when combined with what drugs?
Definition
Drugs that increase catecholamine levels (TCAs, SSRIs, SNRIs, tyramines etc.)
Term
What are the side effects of Selegiline?
Definition
MAO-B inhibitor, increases the adverse motor and cognitive effects of L-DOPA therapy in advanced Parkinson's
Metabolized into amphetamine and methamphetamine
Term
What are the side effects of muscarinic receptor antagonists?
Definition
Sedation and mental confusion
Blurred vision through cycloplegia
Cautious use in narrow-angle glaucoma
Constipation
Urinary retention
Term
What drugs increase the symptoms of schizophrenia by increasing neurotransmitter levels?
Definition
Amphetamines
Methyphenidate and Cocaine
L-DOPA
Term
What are the side effects of typical anti-psychotics?
Definition
Significant motor side effects (EPS) and hyperprolactinemia
Term
What are the side effects of atypical anti-psychotics?
Definition
Minimal EPS and hyperprolactinemia
Term
What causes the side effects seen in first generation typical anti-psychotics?
Definition
Non-target blockade of D2 receptors
Motor side effects aka extrapyramidal symptoms (EPS) due to blockade of dopamine receptors in the nigrostriatal pathway
Term
What causes the autonomic histaminergic side effects seen with the use of all anti-psychotics?
Definition
Blockade of D2 receptors in the tuberoinfundibular pathway causes hyperprolactinemia
Blockade of muscarinic receptors:
Dry mouth, difficulty urinating or retention, constipation, blurred vision, confusion
Blockade of α adrenoceptors: Orthostatic hypotension
Blockade of H1 histamine receptors: Sedation
Term
Which atypical anti-psychotics also cause the EPS and neuroendocrine symptoms at high doses seen with typical anti-psychotic use?
Definition
Risperidone
Olanzapine
Term
What side effect is slightly more pronounced in atypic anti-psychotics compared to typicals?
Definition
Weight gain
Less of a problem with the newest atypicals (Ziprasidone & Aripiprazole)
Term
Why is the use of Clozapine (atypical) restricted?
Definition
Danger of fatal neutropenia
Term
What is an unusual side effect of Clorazapine?
Definition
Instead of causing dry mouth, this drug causes hyper salivation
Term
What are the drawbacks of Olanzapine (atypicals)
Definition
Minimal effective dose is 10 mg. Increased incidence of EPS at doses > 25-30 mg
Weight gain more than the other antipsychotics
Term
What are the drawbacks of Risperidone (atypical)?
Definition
At doses higher than 8 mg:
EPS, Hyperprolactinemia, Weight gain
Term
What are the side effects of Quetiapine (atypical)?
Definition
Somnolence/Sedation
Postural hypotension
Term
What is the black box warning for Aripirprazole?
Definition
Studies have shown that older adults with dementia have an increased chance of death during treatment. Older adults with dementia may also have a greater chance of having a stroke or ministroke or other severe side effects during treatment
Term
Which of the following should not be used in patients with sulfonamide allergies?
Definition
Zonisamide
Term
What are general concerns with use of all anesthetic drugs?
Definition
Very narrow therapeutic index, must monitor levels since the margin between surgical anesthesia and fatal respiratory/circulatory depression is narrow
Most decrease myocardial contractility and reduce BP
All depress respiration markedly and increase arterial PCO2
Term
What are the dangers of using Thiopental as an anesthetic?
Definition
Slowly metabolized, accumulates in the body, prolonged effect if given repeatedly, tissue damage if extravascular
Precipitates when it comes in contact with drugs in acidic solution
Narrow margin of error: CV depression
Term
What are the drawbacks of using Etomidate as an anesthetic?
Definition
Severe nausea
Causes involuntary movements during induction
Risk of adrenocortical suppression
Term
What are the drawbacks of using Ketamine as an anesthetic?
Definition
High incidence of hallucinations etc
Can raise intracranial pressure
Term
What are the side effects of Ziprasidone?
Definition
Newer generation atypical similar to Aripiprazole
Potential for cardiac arrhythmia in patients with baseline risk factors:
Elderly, preexisting cardiac disease
Taking diuretics or medication that prolong QT interval
Term
What is nitrous oxide toxicity?
Definition
Caused by chronic use
Leads to symptoms similar to B12 deficiency (pernicious anemia) such as neuropathy, tinnitus, numbness
Increases cerebral blood flow
Expands air-filled cavities due to being 40x as soluble as nitrogen, is passes from the blood into the cavity faster than nitrogen can diffuse out
Term
Nitrous oxide use is contraindicated in what patients?
Definition
Patients with
bowel obstruction
pneumothorax
middle ear and sinus disease
during general anesthesia for gas-filled eye procedures
Patients with increased intracranial pressure
Term
The Minimal Alveolar Concentration (MAC) for anesthetics decreases in what kind of patients?
Definition
Elderly patients, patients with hypothermia, presence of adjuvant drugs, hypoxemia, hypotension, or anemia
Term
How do inhaled anesthetics affect the cardiovascular system?
Definition
Decrease mean arterial pressure in direct proportion to alveolar concentration
Decrease systemic vascular resistance
Reduce myocardial oxygen consumption causing ischemia
Term
What unique side effect does Halothane have on the cardiovascular system?
Definition
Sensitizes the myocardium to catecholamines
Enflurane and halothane have greater myocardial depressant effects
Term
What are the side effects on the respiratory system when using inhaled anesthetics?
Definition
Dose-dependent decrease in tidal volume and increase in respiratory rate during spontaneous ventilation
Decreased minute ventilation & ventilatory response to CO2
Depresses mucociliary function in the airway
Bronchodilatory effects
Term
What are the side effects on the kidneys when using inhaled anesthetics?
Definition
Decreased renal blood flow
Theoretical nephrotoxicity
Term
How might enflurane and sevoflurane cause nephrotoxicity?
Definition
Metabolism could lead to formation of fluoride ions intrarenally. However, there are no reports of renal injury, risk is theoretical
Term
Which anesthetic can, in rare cases, cause potentially severe and life-threatening hepatitis, particularly in obese patients undergoing multiple exposures within a short amount of time?
Definition
Halothane
Term
How might inhaled anesthetics cause malignant hyperthermia?
Definition
Autosomal dominant genetic disorder of skeletal muscle
Occurs in susceptible individuals undergoing general anesthesia with inhaled agents and muscle relaxants
Term
Which inhaled anesthetics are most likely to cause malignant hyperthermia in susceptible individuals?
Definition
Halothane and enflurane
Involves increase in free calcium concentration
Term
The anesthetic Isoflurane has what unintended side effects?
Definition
May cause MI in patients with coronary disease
Irritant to respiratory tract
Term
The anesthetic Desflurane has what unintended side effects?
Definition
Similar to isoflurane, faster onset and recovery
Respiratory irritant causes cough and laryngospasm
Term
The anesthetic Sevoflurane has what unintended side effects?
Definition
Similar to desflurane but no respiratory irritation
Theoretical risk of nephrotoxicity : No evidence
Term
The anesthetic Enflurane has what unintended side effects?
Definition
Similar to halothane but less metabolism, less toxicity
Risk of epilepsy like seizures
Term
What are the risks associated with spinal anesthesia?
Definition
Bradycardia, hypotension, respiratory depression if it spreads to the brain, urinary retention
Term
What are the neurotoxic effects of local anesthetics?
Definition
All can be neurotoxic at very high concentrations. Ex. Pooling in the cauda equina
Term
Which local anesthetics are more clinically likely to cause neurotoxicity?
Definition
Lidocaine or chlorprocaine
When used for continuous spinal(subarachnoid) block
Term
What are the cardiovascular side effects of local anesthetics?
Definition
Depression of myocardial contractility/strength, conduction block and vasodilation due to blocked Na+ influx
Blockade of AV conduction and Ca+ stores
Vasodilation at vasculature and indirectly inhibited sympathetic activity causes sudden fall in BP
Term
What are the unique cardiovascular effects of cocaine?
Definition
Hypertension, arrhythmias
Term
How might local anesthetics cause cardiovascular collapse?
Definition
Epidural needle or continuous infusion catheters enter an epidural vein and is not recognized
Epidural veins enlarge during pregnancy
Term
How do you rule out inadvertent subarachnoid injection (total spinal results) or intravascular injection (seizure, cardiac effects) with local anesthetics?
Definition
Give a "test dose" of epinephrine containing lidocaine prior to giving a large volume of local anesthetic epidurally
Not always 100% accurate
Term
What are the CNS side effects of local anesthetics?
Definition
Light-headedness, tinnitus, metallic taste, circumoral numbness, drowsiness, slurred speech and nystagmus
At higher levels: Anxiety development of fine tremors of the muscles of the hands and/or face
Tonic/Clonic seizures
Severe CNS depression and death
Term
What local anesthetic has high CNS and CV side effects and are therefore not used?
Definition
Procaine
Term
Prilocaine causes what unusual side effect in high doses?
Definition
Methhemoglobinemia
May lead to accumulation of o-toluidine (oxidizing agent capable of converting HgB to methemoglobin)
Term
What are the concerns associated with the use of epinephrine?
Definition
Cardiac arrhythmias in patients with heart disease or with concomitant use of halothane
May be detrimental to flap viability (grafts)
Dangerous if used on tips of fingers, penis
Hypertension
Term
What types of drugs interact poorly with phase I of succinylcholine?
Definition
Ach esterase inhibitors
Term
What are the side effects of succinylcholine?
Definition
Postoperative muscle pain due to fasciculations
Decreases HR, increases IOP at high doses by blocking ganglionic nicotinic receptors
Hyperkalemia
Term
What types of patients experience greater bouts of hyperkalemia as a side effect of succinylcholine?
Definition
Patients with burns (peaks in 7-10 days) trauma or spinal cord injury, peripheral nerve dysfunction, or muscular dystrophy
Term
What is the most serious possible side effect of succinylcholine?
Definition
Malignant hyperthermia
Term
Which isoqinolone based non-depolarizing blocker can cause hypotension due to ganglion block and release of histamine, bronchoconstriction due to histamine release
Definition
Tubocurarine
Term
Which isoqinolone based non-depolarizing blocker is associated with hypotension, histamine release, the toxic metabolite laudanosine, and has greater accumulation with renal failure
Definition
Atracurium
Doxacurium
Term
Which isoqinolone based non-depolarizing blocker causes the least amount of hypertensive side effects as well as less histamine release and less formation of toxic metabolites?
Definition
Cisatracurium
Term
Which amino steroid based non-depolarizing blocker can promote muscarinic block as a side effect?
Definition
Rocuronium
Term
What are the side effects of neuromuscular junction blockers?
Definition
Respiratory paralysis, histamine release, autonomic effects
Term
Which anesthetics can strongly potentiate and prolong neuromuscular blockade?
Definition
Inhaled neuromuscular junction blocking anesthetics, particularly isoflurane
Term
Potentiation and prolonged relaxant action of neuromuscular blockers occurs with what drugs?
Definition
Aminoglycoside antibiotics and antiarrhythmic agents
Term
What are the side effects of Cyclobenzaprine?
Definition
Marked sedative and antimuscarinic action
May cause confusion and visual hallucinations in some patients
Term
Methocarbamol is contraindicated under what conditions?
Definition
Renal impairment
Term
What is the primary side effect of Carisoprodol?
Definition
Drowsiness, avoid with alcohol
Term
Triggered rhythms are in danger of progressing to what?
Definition
Torsades
Term
What causes Torsades de Points?
Definition
Prolongation of QT due to:
Electrolyte imbalance
Persistent bradycardia
Class I or III drugs (block cardiac K+ channels)
Certain non-cardiac drugs
Congenital QT prolongation
Term
What effect do class IA drugs have on ECG readings?
Definition
Inc QRS
Inc QT
Term
What effect do class IB drugs have on ECG readings?
Definition
Either none or dec QT
Term
What effect do class IC drugs have on ECG readings?
Definition
Inc PR
Inc QRS
QT unchanged or inc
Term
What effect do class II drugs have on ECG readings?
Definition
PR non or inc
QT non or dec
Term
What effect do class III drugs have on ECG readings?
Definition
PR non or inc
QRS non or inc
QT inc
Term
What effect do class IV drugs have on ECG readings?
Definition
PR inc
Term
What are the effects of class IA antiarrhythmics on AP propagation?
Definition
Intermediate acting
Prolongs AP
Term
What are the effects of class IB antiarrhythmics on AP propagation?
Definition
Fast acting
Shortens AP
Term
What are the effects of class IC antiarrhythmics on AP propagation?
Definition
Slow acting
No effect on AP
Term
What drug interactions are seen with Quinidine?
Definition
Reduces Digoxin clearance
Term
What are the side effects of Quinidine?
Definition
Marked nausea
Diarrhea
Cinchonism (deafness, tinnitus, blurred vision)
Thrombocytopenic purpura
Term
Quinidine is contraindicated with what condition?
Definition
Long QT
Term
What are the effects of class IA antiarrhythmics on AP propagation?
Definition
Intermediate acting
Prolongs AP
Term
What are the effects of class IB antiarrhythmics on AP propagation?
Definition
Fast acting
Shortens AP
Term
What are the effects of class IC antiarrhythmics on AP propagation?
Definition
Slow acting
No effect on AP
Term
What are the side effects of Procainamide?
Definition
Lupus-like syndromes, hypotension, depression, hallucination, psychosis
Adjust dosage with renal function
Term
What are the side effects of Disopyramide?
Definition
Pronounced antimuscarinic effects
Dry mouth, blurred vision, constipation, urine retention, and sometimes precipitates glaucoma
Can also worsen heart block & adversely effect sinus node activity
Prolongs QT interval, can cause Torsades
Contraindicated in long QT syndrome
Term
How do you treat class IA antiarrhythmic overdose?
Definition
Cardiac effects can be exacerbated by hyperkalemia
Arrhythmias revered by Sodium Lactate IV which increases the ionic gradient
Sympathomimetics can reverse hypotension
Term
What are the limitations of Lidocaine?
Definition
IV only limits to emergency setting, no maintenance therapy
Adjust dose with reduced hepatic flow such as in CHF or older patients
Term
What are the side effects of Flecainide?
Definition
Very proarrhythmic
CNS effects
Negative ionotropic effects, can aggravate CHF
Term
What are the side effects of Propranolol? What are its contraindications?
Definition
Excessive bradycardia
Bronchospasms
Depression, fatigue
Use with caution in asthma and diabetes
Term
What are the side effects of Sotalol?
Definition
Can prolong QT intervals and cause Torsades
Dyspnea and dizziness
Adjust in renal disease
Term
What are the side effects of Class IV antiarrhythmics and what makes them worse?
Definition
AV block in large doses or in patients with partial block
Made worse with beta-blockers
Term
What are the side effects of Adenosine?
Definition
Flushing, hypotension, chest pain, dyspnea
Term
What electrolyte abnormality causes AV block with Digitalis?
Definition
Hypokalemia
Term
What are the side effects of nitrates?
Definition
Flushing, Nausea
Throbbing Headache (meningeal artery vasodilation)
Orthostatic Hypotension
Reflex Tachycardia
Syncope, Dizziness
Large IV dose can cause methemoglobinemia
Term
What is the drawback of continued use of nitrates?
Definition
Tolerance develops after days of continual therapy
Overcome with treatment free intervals during the night
Term
Nitrates are contraindicated with what other drugs?
Definition
Phosphodiesterase inhibitors (Sildenafil, Tadelafil)prolongs effects, can cause hypotensive shock
Migraine medication can increase BP and decrease effects
Term
What is the drawback of nitrate tablets?
Definition
Volatile, loses potency when exposed to air and light, only usable for 6 months after opening
Term
What are the side effects of Bepiridil?
Definition
Heart failure if combined with beta-blockers
Torsades and other arrhythmias
Agranulocytosis
Term
What are the side effects of Verapamil?
Definition
Constipation & Gingival hyperplasia
Sinus bradycardia
High doses can cause myocardial depression, heart failure, edema, hypotension
Term
What are the side effects of Diltiazem?
Definition
Sinus bradycaria
AV block, Heart failure (When used in combination with beta blockers)
Peripheral effects (hypotension, edema)
Term
What cardiac drugs are generally avoided in variant angina?
Definition
Beta-lockers, have minimal effects
Term
What is acute coronary syndrome (ACS)?
Definition
A life threatening condition in pts w/coronary disease
Continuum that ranges from an unstable pattern of angina pectoris to the development of a large acute myocardial infarction (irreversible necrosis of the heart muscle)
Term
What are the side effects of heparin?
Definition
Bleeding is primary adverse effect
Osteoporosis
Heparin induced throbocytopenia
Allergy due to animal origin
Term
What are the contraindications to heparin?
Definition
Hypersensitivity to UFH
Hypersensitivity, pork products, or methylparaben with LMWH
History of HIT
Term
What is given for a heparin overdose?
Definition
Protamine
Term
What are the side effects of Rivaroxaban?
Definition
Bleeding
Black box warning of possible paralysis with enuraxial anesthesia or spinal puncture
Term
What are the side effects of the monovalent direct thrombin inhibitors (Argatroban and Dabigatran etexilate)?
Definition
Hemorrhage (serious, most common)
Term
Lepirudin is contraindicated alongside what condition?
Definition
Renal insufficiency
Term
Argatroban is contraindicated alongside what condition?
Definition
Hepatic insufficiency
Term
Dabigatran should be avoided alongside what other drugs?
Definition
P-glycoprotein inducers (i.e. rifampin) reduces exposure
Term
What are the side effects of Warfarin?
Definition
Hemorrhage of the bowel or the brain
Correct dosing requires continual monitoring
Birth defects, crosses placenta
Term
What are contraindications to thrombolytic therapy?
Definition
Recent surgery (w/in 10 days)
Serious GI bleed w/in 3 months
History of HTN
Active bleeding disorder
Previous cerebrovascular accident w/in 30mo
Aortic dissection
Acute pericarditis
Term
What are the side effects of fibrinolytic drugs?
Definition
Hemorrhage due to lysis of fibrin in physiological thrombi
Term
What are the side effects of Tranexamic acid and Aminocaproic acid?
Definition
Thrombi formation that can lead to renal failure
Term
How does injury encourage the formation of a thrombus?
Definition
When underlying basal lamina is exposed to the blood stream, PGI2 decreases -> GPIa/IIa receptors on platelets and von Willebrand factor -> COX-1 -> ADP -> GPIIb/IIIa activation -> platelet aggregation
Term
What are the side effects of Aspirin?
Definition
Bleeding, salicylism – generally with larger doses than used for this indication
Term
What are the side effects of ADP antagonists (Clopidogrel and Prasugrel)?
Definition
Thrombotic thrombocytopenic purpura
Term
What are the side effects of Aspirin?
Definition
Bleeding, salicylism – generally with larger doses than used for this indication
Term
What are the side effects of ADP antagonists (Clopidogrel and Prasugrel)?
Definition
Thrombotic thrombocytopenic purpura
Term
When is Celocoxib contraindicated?
Definition
With cardiovascular disorders
Term
How does aspirin affect uric acid secretion?
Definition
At low doses, uric acid secretion is decreased
At high doses, excretion is increased, can precipitate gout
Term
What are the side effects of aspirin?
Definition
Reye's syndrome
Liver dysfunction and encephalopathy
Contraindicated in children with viral infections
Term
What are the symptoms of aspirin overdose?
Definition
GI distress and bleeding
Bronchoconstriction
Renal dysfunction
Hypersensitivity
Renal dysfunction
Term
What are the effects of Indomethacin?
Definition
Prominent anti-inflammatory, antipyretic and analgesic activity
Reduces polymorphonuclear leukocyte motility
Reduces development of cellular exudates and reduces vascular permeability in injured tissue
Term
What is the ONLY NSAID that does not cause renal dysfunction?
Definition
Sulindac
Term
Why are COX-2 selective inhibitors such as Celocoxib or Dicolfenac dangerous in patients with cardiovascular disease?
Definition
May increase risk of thrombosis which increases risk of MI or stroke
Term
When are NSAIDs contraindicated with pregnancy?
Definition
During the third-trimester due to risk of post-partum hemorrhage and delayed labor
Term
What is the side effect of colchicine that severely limits its use?
Definition
Significant GI distress
Term
Probenicid is contraindicated with what condition?
Definition
Renal dysfunction
Term
What factors promote rheumatic arthritis?
Definition
Genetic disposition
Age related wear and tear
Hypothermia
Infection
Term
What are the pro-inflammatory cytokines involved in the progression of rheumatoid arthritis?
Definition
IL-1
IL-6
TNF-alpha
Term
C-reactive protein in the blood is indicative of the presence of what?
Definition
Inflammation
Term
What are the systemic signs of rheumatoid arthritis?
Definition
Rheumatoid nodules
Vasculitis in finger beds
Pleural effusions and pulmonary fibrosis
Pericarditis
Splenomegaly, neutropenia
Term
What is the drawback of DMARD therapy for rheumatoid arthritis?
Definition
Slow acting, may take months for benefit
No analgesic activity
Term
What should be avoided with Methotrexate?
Definition
Alcohol
Essential to monitor liver function
Must give with folic acid supplements
Term
What are the side effects of Methotrexate?
Definition
Hepatotoxicity
Pulmonary fibrosis
GI distress
Pregnancy category X
Term
What are the side effects of Hydroxychloroquine?
Definition
A quinine containing drug which causes cinchoism ( flushed and sweaty skin, ringing of the ears (tinnitus), blurred vision, impaired hearing, confusion, reversible high-frequency hearing loss, headache, abdominal pain, etc)
Term
What are the side effects of Sulfasalazine?
Definition
Causes GI distress, start with low dose
Term
What are the side effects of Leflunomide?
Definition
Metabolized to active metabolite, caution in renal dysfunction
Can combine with methotrexate but high risk of hepatotoxicity
Term
Etanercept should be avoided alongside what drugs?
Definition
May be combined with DMARD with the exception of Anakinra
Term
What are the general side effects of most DMARDs?
Definition
Injection site reactions
1st dose phenomenon
Headache, dizziness
Immunosuppressive (AVOID with infections)
Term
Anakinra is contraindicated with what drugs?
Definition
TNF antagonists (Etanercept and Infliximab)
Abatacept
Term
Rituximab should be avoided with what conditions?
Definition
Renal dysfunction
Separate from hypertensive therapy for 12hrs
Term
What are the side effects of Rituximab?
Definition
Angioedema
Fatigue
Nausea, vomiting
Headache
Hypotension
Rash, urticaria
Term
How does beta-2 receptor polymorphism impact the treatment of asthma with beta-2 agonists?
Definition
An Arginine at position 16 increases the risk for exacerbations with short- or long-term agonists
Term
When should oral agents be used instead of inhaled for the treatment of asthma?
Definition
Greater incidence of side effects vs. inhaled
Used in young children unable to use inhalers
Term
What are the side effects of beta-2 agonists?
Definition
Nervousness/anxiety
Palpitations
Tachycardia
Tremors
Term
What drug interactions are there for beta-2 agonists?
Definition
MAO-I
TCA antidepressents
Avoid Anything that increases catecholamines
Term
Beta-2 agonists should be avoided with what conditions?
Definition
Cardiovascular disorders
Convulsive disorders
Diabetes mellitus
Term
What are the side effects of glucocorticoids?
Definition
Epistaxis
Bone demineralization (less likely in inhaled)
Oropharyngeal candidiasis
Pharyngitis
HPA axis suppression (unlikely with inhaled)
Glaucoma
Headache
Fewer systemic effects when inhaled
Term
Glucocorticoids should be avoided alongside what conditions?
Definition
Infections
Glaucoma
If oral, caution with CYP450 metabolizers, diabetes, diabetes, peptic ulcers, osteoporosis
Term
What are the side effects of leukotriene inhibitors?
Definition
Elevated liver enzymes with Zileuton
Nausea/dyspepsia
Neuropsychiatric events: agitation, depression, anxiety, etc.
Term
Leukotriene inhibitors have what drug interaction?
Definition
Zileuton decreases warfarin and theophylline clearance
Term
Ipratropium should be cautioned alongside what other asthma drug?
Definition
Combined with albuterol can cause rare occurrence of MI
Term
What are the side effects of muscarinic antagonists?
Definition
Palpitations
Nervousness
Fatigue
Headache
Dry mucus membranes
Influenza-like symptoms
Term
What conditions require caution when using muscarinic antagonists?
Definition
Acute episode of bronchospasm
Myasthenia gravis
Narrow-angle glaucoma
Prostatic hyperplasia
Bladder obstruction
Term
Why is theophylline not commonly used to treat asthma?
Definition
Narrow therapeutic window
Caution in drugs that decrease metabolism or clearance such as zileuton
High doses can cause seizures or cardiac arrhythmia
Term
What are the side effects of Amalizumab?
Definition
Injection-site reactions
Anaphylactic shock, give under supervision
Symptoms return upon cessation of treatment
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