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Pharm - RA
pharm t6
28
Pharmacology
Graduate
04/22/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
First line Tx in RA
Definition
DMARDs: MTX wn 3mo of dx
Term
dose frequency for MTX
Definition
Q wk
Term
onset of action for MTX
Definition
rapid 3-6 wks
Term
dont take MXT w:
Definition
milf or caffeine
Term
MOA of MTX:
Definition
folate inhibitors; inhibits purine/pyrimidine syn shunts to adenine which is antiinflammatory
Term
frequency of sulfasalazine dose"
Definition
BID
Term
MOA of sulfasalazine:
Definition
broken down by bacteria in the colon to ASA and Sulfa SAS; SAS absorbed ASA excreted
Term
contraindications to sulfasalazine:
Definition
hypersensativity to ASA or Sulfa
Term
onset of action for sulfasalazine:
Definition
1-3 mo
Term
still detected after 2 years:
Definition
leflunomide
Term
freq of dose for leflunomide:
Definition
QD
Term
MOA of leflunamide:
Definition
same as MTX
Term
onset of action for leflunomide:
Definition
1-3mo
Term
traditional DMARD that is highly protein bound
Definition
leflunomide
Term
retinal damage:
Definition
hydroxychloroquine
Term
freq of dose in hydroxychloroquine:
Definition
BID w food
Term
onset of action for hydroxychloroquine
Definition
2-6mo
Term
4 traditional DMARDs
Definition
1. MTX
2. Sulfasalozine
3. Leflunamide
4. hydroxychloroquine
Term
suffixes for biologic DMARDs
Definition
mab and cept
Term
which biologic DMARDs are IV admin?4
Definition
1. inflixamab
2. rituximab
3. abatacept
4. tolcilizumab
Term
2 biologics that are chimeric:
Definition
1. rituximab
2. infliximab
Term
IL-1 receptor antagonist:
Definition
anakinra
Term
binds to CD-20 on Bcells:
Definition
Rituximab
Term
inhibits T cell activation:
Definition
abatacept
Term
IL-6 receptor antagonist:
Definition
Tocilizumab
Term
indication for minocycline/MOA:
Definition
1 used in low dz activity
2. used in pts w better prognosis
3. MOA: inhibits collagenase activity
Term
biologic DMARD that is from hamster:
Definition
rituxumab
Term
biologic that is from mice:
Definition
inflixamab
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