Shared Flashcard Set

Details

Pharm Quiz 4
2/7
58
Pharmacology
Graduate
02/08/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
rhinitis
Definition
inflammation of the nasal mucous membrane
Term
allergic rhinitis
Definition
seasonal or perennial
Term
non-allergic rhinitis
Definition
infectious or idiopathic or vasomotor
Term
rhinitis medicamentosa
Definition
drug induced
Term
rhinitis
Definition
one of top ten reasons to present to primary care clinician
Term
rhinitis
Definition
affects 100% of population
Term
guides therapy with chronic rhinitis symptoms
Definition
determining etiology or allergens
Term
allergic rhinitis incidence
Definition
highest in people ages 15-25 yo
Term
atopic dermatitis
Definition
skin allergies
Term
allergic rhinitis
Definition
symptomatic disorder of the nose induced by IgE-mediated inflammation after allergen exposure
Term
symptoms of allergic rhinitis
Definition
rhinorrhea, nasal obstruction, nasal itching, sneezing
Term
comorbidities of allergic rhinitis
Definition
asthma, conjunctivitis, rhinosinusitis
Term
seasonal allergens
Definition
tree pollen, grass pollen, weed pollen
Term
perennial allergic rhinitis
Definition
overlapping allergies
Term
perennial allergens
Definition
dust mite fecal proteins, animal dander, cockroaches, mold
Term
sensitization
Definition
production of IgE directed at specific proteins
Term
mast cell degranulation
Definition
histamine, chemical modulators, arachidonic acid metabolites
Term
degranulation
Definition
release of the contents of granules into the extracellular space
Term
early phase response of allergic reaction
Definition
sneezing, pruritis, increased vascular and mucosal permeability, smooth muscle contraction, influx of inflammatory cells, mucous secretion, chemotaxis, decreased airway permeability
Term
late phase response of allergic reaction
Definition
infiltration and activation of migrating cells, sinus passage obstruction, hyperresponsive inflamed mucosa
Term
diagnostic signs of the eyes
Definition
allergic shiners and watery eyes
Term
diagnostic signs of the nose
Definition
transverse nasal crease, pale, blue edematous turbinates, clear, watery nasal discharge (bilateral)
Term
nasal scrapings
Definition
microscopic exam shows eosinophils
Term
diagnostic signs of the TM
Definition
retracted or bulging due to blockage of the eustachian tube
Term
diagnostic signs of allergic rhinitis
Definition
lymphoid hyperplasia, cough, pain in all of the sinuses upon deep palpation
Term
angle that skin is pricked
Definition
45-60 degrees
Term
angle that skin is punctured
Definition
90 degrees
Term
when the positive control is read in allergy testing
Definition
after 10 minutes
Term
when the allergens are read in allergy testing
Definition
after 15-20 minutes
Term
positive negative control
Definition
dermagraphism from phenolated glycerol/saline
Term
negative positive control
Definition
medication reaction or hypoactive skin from histamine hydrochloride
Term
0 grade in allergy testing
Definition
no reaction - 1-3 mm wheal
Term
5+ grade in allergy testing
Definition
erythema with >10 mm wheal and pseudopods
Term
3 ways to treat allergic rhinitis
Definition
avoidance of identified allergens, pharmacotherapy, or immunotherapy
Term
most likely reason for positive skin prick
Definition
cats, then dust mites, then dogs
Term
intranasal corticosterioid
Definition
treats AR/VMR
Term
intranasal antihistamine
Definition
treats AR/VMR
Term
nasal saline
Definition
treats AR/VMR
Term
oral antihistamine
Definition
treats AR
Term
decongestant
Definition
treats VMR
Term
cromolyn
Definition
treats AR
Term
ipratropium bromide
Definition
treats VMR
Term
oral corticosteroids
Definition
treats AR
Term
% pts symptomatic >4mo/yr; >9mo/yr
Definition
50%; 20%
Term
Pure AR%
Definition
43%
Term
Pure non-AR %
Definition
23%
Term
Mixed AR%
Definition
34%
Term
% with allergic component; non-allergic component
Definition
77%; 57%
Term
6 predisposing factors for AR
Definition
asthma, atopic dermatitis, FH of allergy, exposure to 2nd hand smoke, occup/enviro exposures, early intro of food/formula
Term
Atopic march
Definition
atopic ezcema/food allergies > asthma/perennial rhinitis > seasonal rhinitis/conjunctivitis
Term
Pollen allergen in spring
Definition
trees
Term
Pollen allergen in spring-late summer
Definition
grass
Term
Pollen allergen in late summer-early fall
Definition
weeds
Term
AR have inherited predisposition to
Definition
phenotype 2 helper T2 cells
Term
How long before late phase response occurs?
Definition
4-8 hrs
Term
Predominant source of histamine in early phase
Definition
mast cells
Term
Predominant source of histamine in late phase
Definition
basophils
Term
Indications for allergy testing
Definition
chronic/recurrent symptoms, symptoms not controlled by avoidance/meds, need for immunotherapy
Supporting users have an ad free experience!