AKA: Ritalin

Mech: incr. NE vesicular release (like amphetamines)

Use: ADHD

Antipsychotic

(others: trifluperazine, fluphenazine, thioridazine)

Mech: D2 antag

Use: Schizo (pos. sx)psychosis, mania, Tourette's

Tox: EPS SE (dystonia → akinesia → akathisia → tardive dyskinesia); galactorrhea (incr. PRL); anti-M/α/His effects; neuroleptic malign synd - rigidity, myoglobinuria, autonomic instab., high fever (tx: dantrolene, DA ags)

Antipsychotic (others: haloperidol, trifluperazine, fluphenazine, thioridazine)

Mech: D2 antag

Use: Schizo (pos. sx), psychosis, mania, Tourette's

Tox: EPS SE (dystonia → akinesia → akathisia → tardive dyskinesia); galactorrhea (incr. PRL); anti-M/α/His effects; neuroleptic malign synd - rigidity, myoglobinuria, autonomic instab., high fever (tx: dantrolene, DA ags)

Atypical antipsychotic

Mech: block 5-HT2, α, H1, & DA

Use: schizo (pos. & neg. sx); OCD, anx, depr, mania, Tourette's'

Tox: Fewer EPS & anti-M effects than traditional antipsychs

Atypical antipsychotic

Mech: block 5-HT2, α, H1, & DA Rs

Use: schizo (pos. & neg. sx)Tox: Fewer EPS & anti-M effects than traditional antipsychs

Atypical antipsychotic

Mech: block 5-HT2, α, H1, & DA

Use: schizo (pos. & neg. sx)

Tox: Fewer EPS & anti-M effects than traditional antipsychs

Atypical antipsychotic

Mech: block 5-HT2, α, H1, & DA

Use: schizo (pos. & neg. sx)

Tox: Fewer EPS & anti-M effects than traditional antipsychs

Atypical antipsychotic

Mech: block 5-HT2, α, H1, & DA

Use: schizo (pos. & neg. sx)

Tox: Fewer EPS & anti-M effects than traditional antipsychs

Use: bipolar (blocks relapse & acute mania); SIADH

Tox (narrow TI): tremor, hypothyr, polyuria (ADH antag → nephrogenic DI), teratogenesis

Mech: 5-HT1A ag

Use: generalized anx d/o

Note: does not cause sedation, addiction, or additive depression w/ alc; low abuse pot.

TCA

Mech: NE & 5-HT reuptake blocker

Use: depression, bedwetting (imipramine)

Tox: sedation, anti-M effects (3o amitriptyline > 2o nortriptyline); convulsions, coma, arrhythmias, confusion/halluc. in elderly d/t anti-M (use nortriptyline)

Antidote: NaHCO3 for CV tox

TCA

Mech: NE & 5-HT reuptake blocker

Use: depression

Tox: sedation, anti-M effects (3o amitriptyline > 2o nortriptyline); convulsions, coma, arrhythmias, confusion/halluc. in elderly d/t anti-M (use nortriptyline)

Antidote: NaHCO3 for CV tox",1,1

TCA

Mech: NE & 5-HT reuptake blocker

Use: depression

Tox: least sedating, anti-M effects (3o amitriptyline > 2o nortriptyline); convulsions, coma, arrhythmias, confusion/halluc. in elderly d/t anti-M (use nortriptyline)

Antidote: NaHCO3 for CV tox

TCA

Mech: NE & 5-HT reuptake blocker

Use: depression

Tox: sedation, anti-M effects (3o amitriptyline > 2o nortriptyline); convulsions, coma, arrhythmias, confusion/halluc. in elderly d/t anti-M (use nortriptyline)

Antidote: NaHCO3 for CV tox

TCA

Mech: NE & 5-HT reuptake blocker

Use: depression, OCD (clomipramine)

Tox: sedation, anti-M effects (3o amitriptyline > 2o nortriptyline); convulsions, coma, arrhythmias, confusion/halluc. in elderly d/t anti-M (use nortriptyline)

Antidote: NaHCO3 for CV tox

TCA

Mech: NE & 5-HT reuptake blocker

Use: depression

Tox: sedation, anti-M effects (3o amitriptyline > 2o nortriptyline); convulsions, coma, arrhythmias, confusion/halluc. in elderly d/t anti-M (use nortriptyline)

Antidote: NaHCO3 for CV tox

TCA

Mech: NE & 5-HT reuptake blocker

Use: depression

Tox: sedation, anti-M effects (3o amitriptyline > 2o nortriptyline); convulsions, coma, arrhythmias, confusion/halluc. in elderly d/t anti-M (use nortriptyline)

Antidote: NaHCO3 for CV tox

SSRI

Mech: 5-HT reuptake inhib

Use: depression, OCD

Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/ MAO-I (hyperthemia, rigidity, CV collapse, flushing)

Note: 2-3 wks for effect

SSRI

Mech: 5-HT reuptake inhib

Use: depression, OCD

Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/ MAO-I (hyperthemia, rigidity, CV collapse, flushing)

Note: 2-3 wks for effect

SSRI

Mech: 5-HT reuptake inhib

Use: depression, OCD

Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/ MAO-I (hyperthemia, rigidity, CV collapse, flushing)

Note: 2-3 wks for effect

SSRI

Mech: 5-HT reuptake inhib

Use: depression, OCD

Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/ MAO-I (hyperthemia, rigidity, CV collapse, flushing)

Note: 2-3 wks for effect

Antidepressant (AKA: wellbutrin)

Mech: incr. NE & DA

Use: depr, smoking cessation

Tox: stimulant, seizure in bulimic

Note: no sexual SE

Antidepressant

Mech: inhibs 5-HT, & NE reuptake

Use: depr, generalized anx d/o

Tox: incr. BP, stimulant

Antidepressant

Mech: inhibs NE>5-HT reuptake

Use: depr, DM periph neuropathy

Tox: incr. BP, stimulant

Antidepressant

Mech: 1) α2 antag → incr. NE & 5-HT release;

2) 5-HT2 & 5-HT3 antag

Tox: sedation, incr. appetite

Antidepressant

Mech: blocks NE reuptake

Tox: sedation, ortho hypoTN

Antidepressant

Mech: inhibs 5-HT reuptake

Use: insomnia (extremely high dose req'd for depr)

Tox: sedation, nausia, priapism

MAO-I

Mech: blocks MAO → incr. DA, NE, Epi

Use: depr, anx, hypochondriasis

Tox: hypertensive crisis w/ tyramine & β-agContra: SSRIs (5-HT synd), meperidine (active metabolite → seizures)

MAO-I

Mech: blocks MAO → incr. DA, NE, Epi

Use: depr, anx, hypochondriasis

Tox: hypertensive crisis w/ tyramine & β-agContra: SSRIs (5-HT synd), meperidine (active metabolite → seizures)