rosuvastatin

hyperlipidemia

5-40 mg/day

fluvastatin

hyperlipidemia (type IIa,IIb)

20 - 80 mg qd

Fluvastatin

Hyperlipidemia (type IIa, IIb)

80 mg q hs

Atorvastatin

Hyperlipidemia (Type IIa, IIb, IV)

10-80 mg qd

Lovastatin

Hyperlipidemia (Type IIa, IIb)

20-80 mg q pm

Take w/ evening meal

Pravastatin

Hyperlipidemia (type IIa, IIb)

10-80mg q hs

Simvastatin

Hyperlipidemia (type IIa, IIb, IV)

5-80mg q pm

Gemfibrozil

Hyperlipidemia (type IV)

600mg bid

Take 30 min before morning and evening meals

Fenofibrate

Hyperlipidemia (type IIa, IIb, and IV)

48 - 145 mg qd

Take with food

Omega-3 acid ethyl esters

Hypertriglycidemia (>500 mg/dL)

4 caps daily or 2 caps bid

Take with food

Cholestyramine

Hyperlipidemia (Type IIa)

4-16g qd

Can divide prn; max dose 24 grams; mix w/ water prior to administration

Colesevelam

Hyperlipidemia (Type IIa)

6 qd or 3 bid

Take with meals

Niacin

Hyperlipidemia (type IIa, IIb, IV)

500-2000mg qhs with snack

Titration necessary; premedicate w/ ASA or NSAID

Ezetemibe

hyperlipidemia (type IIa)

10 mg qd

Ezetemibe/Simvastatin

Hyperlipidemia

10/10 - 10/80 mg qd

Furosemide

CHF

20 - 160 mg qd

may require bid dosing; oral dose > 300 mg/day may be needed

Bumetanide

CHF

0.5 - 4 mg qd

Max dose of 10mg qd may be needed

Torsemide

CHF:    20-200 mg qd

HTN:    10-200 mg qd

HCTZ

HCTZ

HTN

12.5-50 mg qd

Indapamide

CHF:   2.5 - 5 mg qd

HTN:     1.25 - 2.5 mg qd

Metolazone

CHF: 2.5 - 20 mg qd

renal dysfunction: 2.5 - 20 mg qd

Spironolactone

edema (CHF, cirrhosis):     25-200 mg qd

HTN:     50 - 100 mg qd

For HTN, can start 25 mg qd; bid is acceptable

Eplerenone

HTN

50 mg qd

After 4 wks, you can titrate up to 50 mg bid prn

Triamterene/HCTZ 37.5/25mg

HTN

1-2 caps qd

Triamterene/HCTZ

HTN

1qd

Comes in 2 strengths:

Maxide 25 (37.5/25mg)

Maxide 50 (75/50mg)

Dyazide is a cap; maxide is a tablet

Potassium Chloride

supplement

16 - 80 mEq/day

Can divide to minimize GI upset

Take w/ meals and a full glass of water

Clopidogrel

decrease risk of vascular events

 75mg qd

Report unusual bleeding

Ticlodipine

stroke reduction

250mg bid

take with meals

Dipyridamole

Thrombotic event risk reduction (cardiac valve replacement)

100 mg qid

Often co-administered w/ warfarin/ASA

dipyridamole/ASA

CVA prevention with h/o TIA or CVA

1bid

200/25mg caps

Pentoxyfilline

Intermittent Claudication

400 mg tid

take with meals

Cilostazol

Intermittent Claudication

100 mg bid

Take at least 30 min before or 2 hrs after meals

Warfarin

Afib, venous thromboembolism, others

Dose is highly variable

Avg dose is 4-5 mg/day; avoid alcohol & ASA

Terazosin

HTN

1-5 mg qd

Start at low dose; take 1st dose at bedtime

Doxazosin

BPH

4 mg q am with breakfast

Can increase to 8 mg qd in 8 wks

Doxazosin

HTN/BPH

1-16 mg qd

Start at low dose; take 1st dose at bedtime to avoid syncope

Prazosin

HTN

2-5 mg tid

Start at low dose; take 1st dose at bedtime to avoid syncope

Hydralazine

HTN

10-50 qid

Clonidine

HTN 

0.1 - 0.4 mg bid

Do not skip doses (rebound HTN)

Clonidine

HTN

0.1 mg patch q 7d

Rotate application site

nifedipine

 HTN:   30 - 90 mg qd

vasospastic/chronic stable angina:   30 - 180 mg qd

Take on an empty stomach

nifedipine

vasospastic/chronic stable angina

30 - 120 mg qd in divided doses

not an optimal dosage form for this indication

Felodipine

HTN

2.5 - 20 mg qd

Amlodipine

HTN:    2.5 - 10 mg qd

vasospastic/chronic stable angina:    10 mg qd

Lotrel

Amlodipine/benazepril

HTN

1qd

multiple strengths available

Diltiazem

Angina prophylaxis

30 mg qid and titrate prn

Take before meals and at bedtime

Diltiazem

HTN

120 - 360 mg qd

Take on an empty stomach

diltiazem

HTN

120 - 540 mg qd

Take on an empty stomach

verapamil

HTN

120 - 240 mg qd to bid

There are many SR brands (calan, verelan)

Verapamil

vasospastic/chronic stable angina

80 - 160 mg tid

Isosorbide dinitrate

angina prophylaxis

40 mg tid

Dose at 7-12-5 for nitrate free interval

Isosorbide dinitrate SR

angina prophylaxis

40 mg bid

dose at 8 and 2 for a nitrate free interval

Isosorbide mononitrate

angina prophylaxis

30 - 240 mg qd

Nitroglycerin

acute anginal pain

q 5 min prn

3 tabs in 15 min; then 911

Transdermal nitroglycerin

prevention and Tx of angina

apply 1 patch q am; remove after 12 hrs

Do not wear for > 12 hrs unless directed

Digoxin

CHF/Afib and flutter

0.125 - 0.25 mg qd

Amiodarone

Atrial and ventricular arrhythmias

200 - 400 mg qd (maintenance dose)

Propranolol

HTN

40 - 480 mg bid

propranolol

angina prophylaxis

60 - 160 mg qd

Atenolol

HTN:     25 - 100 mg qd

angina prophylaxis:     50 - 200 mg qd

atenolol/chlorthalidone

HTN

1qd

metoprolol

prophylaxis of angina/HTN

50 mg bid

target 100 mg bid if tolerated; take w/ food to increase absorption

metoprolol

angina prophylaxis:   100 mg qd (max: 400mg/day)

HTN:    50 - 100 mg qd (50 - 400 mg/day)

CHF:   12.5 - 200 mg qd (individualized; double the dose q 2 wks as tolerated to a max of 200 mg/day)

Labetolol

HTN

200 mg bid

Bisoprolol

HTN

5 mg qd

Bisoprolol/HCTZ

HTN

1qd

Ramipril

HTN

2.5 - 20 mg qd

Captopril

HTN

25mg tid

take 1 hr before meals

Benazepril

HTN

10 - 80 mg qd

Benazepril/HCTZ

HTN

1qd

Trandolapril

HTN

 2 - 4 mg qd

Fosinopril

CHF:   10 - 40 mg qd

HTN:   20 - 80 mg qd

Univasc

Moexipril

HTN

7.5 - 30 mg qd

Take on an empty stomach

Enalapril

CHF:    5 - 40 mg qd

HTN:    10 - 40 mg qd

Enalapril/HCTZ

HTN

1-2 tabs qd

Lisinopril

CHF:  5 - 40 mg qd (target: 20 - 40 mg qd)

HTN:   5 - 40 mg qd

Lisinopril/HCTZ

HTN

10/12.5 qd or 20/25 qd

Combination not indicated for initial Tx of HTN

Candesartan

HTN

8 - 32 mg qd

Irbesartan

HTN/diabetic nephropathy

150 - 300 mg qd

Irbesartan/HCTZ

HTN

150/12.5 - 300/12.5 qd

Combination not indicated for initial Tx of HTN

Losartan

HTN/diabetic nephropathy

25 - 100 mg qd

Losartan/HCTZ

HTN

50/12.5 - 100/25 qd

Valsartan

CHF: 80-160 bid (titrate to highest dose tolerated)

HTN:  80 - 320 qd

Valsartan/HCTZ

HTN

1 qd

The combination product may be substituted for titrated component.

Olmesartan

HTN

 20 - 40 mg qd

Olmesartan/HCTZ

HTN

1 qd

The combination product may be substituted for the titrated component.

Telmisartan

HTN

20 - 80 mg qd

Carvedilol

CHF: starting dose - 3.125mg bid; titrate up to 25mg bid if pt is < 85kg; titrate up to 50mg bid if pt is > 85kg.

HTN: starting dose: 6.25mg bid; titrate up to 25mg bid

Quinapril

HTN

20-80mg qd