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Pharm One Liners
LECOM
195
Pharmacology
Graduate
02/14/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Ondansetron, granisetron,
dolasetron and alosetron
Definition
5HT-3 antagonist used in chemotherapeutic induced
emesis
Term
Sumatriptan, naratriptan, and rizatriptan
Definition
5HT-1d agonist used for migraine headaches
Term
Diphendydramine
Definition
1st generation antihistamine that is highly sedating
Term
Cosyntropin
Definition
ACTH analog used for diagnosis of patients with corticosteroid abnormality
Term
Ergonovine and ergotamine
Definition
Agents for reduction of postpartum bleeding
Term
Ketanserin cyproheptadine, and phenoxybenzamine
Definition
Agents used in treatment of carcinoid tumor
Term
Tamoxifen
Definition
Anti-estrogen used for estrogen receptor + breast cancer
Term
Aminocaproic acid
Definition
Antidote for tissue plasminogen activator (t-PA), streptokinase
Term
Protamine
Definition
Antidote used for heparin toxicity
Term
Atropine, pralidoxime (2-PAM)
Definition
Antidote used for organophosphate/anticholinesterase poisoning
Term
Amoxicillin
Definition
Cheap wide spectrum antibiotic DOC of otitis media
Term
Gynecomastia and hyperkalemia
Definition
Common SE of spironolactone
Term
Metronidazole
Definition
DOC for tx of pseudomembranous colitis
Term
Odansetron
Definition
DOC of chemo induced nausea and vomiting
Term
Leuprolide
Definition
Drug is used with testosterone for male fertility
Term
Raloxifene (SERM-selective estrogen receptor modulator)
Definition
Increase bone density, also being tested for breast CA tx.
Term
Paclitaxel (taxol)
Definition
Interact with microtubules (but unlike vinca which prevent disassembly of tubules), it stabilizes tubulin and cells remain frozen in metaphase
Term
Allopurinol
Definition
Interaction with this drug requires dose reduction of 6-MP
Term
Inhibit DNA gyrase
Definition
MOA of quinolones
Term
L-thyroxine (T4)
Definition
Most widely used thyroid drugs such as Synthroid and Levoxyl contain
Term
Raloxifene
Definition
Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and currently being tested for treatment of breast cancer (Stars study)
Term
Blocks peptidoglycan synthesis
Definition
Vancomycin MOA
Term
Flunitrazepam (rohypnol)
Definition
"Date rape drug"
Term
Fexofenadine, loratadine, and cetirizine
Definition
2nd generation antihistamines
Term
Tamsulosin (Flomax)
Definition
A1a-selective blocker used for BPH
Term
Efficacy
Definition
Ability of drug to produce a biologic effect
Term
pregnancy and with K+
Definition
Ace inhibitors are contraindicated in
Term
Antipyretic and analgesic activity
Definition
Acetaminophen only has
Term
Presynaptic mu, delta, and kappa receptors
Definition
Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release
Term
Desmopressin (DDAVP)
Definition
ADH agonist used for pituitary diabetes insipidus
Term
Cyanocobalamin (Vit B12)
Definition
Agent for pernicious anemia
Term
Clozapine
Definition
Agent having no effect on D2 receptors, blocks D4, reserved for resistant schizophrenia, and can cause agranulocytosis
Term
Ethanol
Definition
Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol-oxidizing system (MEOS)
Term
Erythropoietin
Definition
Agent used for anemias associated with renal failure
Term
Indomethacin
Definition
Agent used for closure of patent ductus arteriosus
Term
Folic acid
Definition
Agent used for megaloblastic anemia (but does NOT reverse neurologic symptoms) and decrease neural tube defects during pregnancy
Term
Xanthine oxidase
Definition
Allopurinol treats chronic gout by inhibiting
Term
Hypertension
Definition
Alpha 1 agonist toxicity
Term
Prazosin, terazosin and doxazosin (-AZOSIN ending)
Definition
Alpha 1selective blockers
Term
Nateglinide
Definition
Amino acid derivative
Term
Megaloblastic anemia
Definition
Anemia caused by trimethoprim
Term
Dry cough
Definition
Angiotensin receptor blockers do NOT cause
Term
sulfamethoxazole/ trimethoprim
Definition
Anti-biotic frequently used for chronic UTI prophylaxis
Term
Odansetron, granisetron
Definition
Anti-emetics used in association with anti-cancer drugs that are 5-HT3 (serotonin receptor subtype ) antagonist
Term
Sulfonamides
Definition
Anti-microbials that cause hemolysis in G6PD-deficient patients
Term
Clozapine
Definition
Anti-psychotic not shown to cause tardive dyskinesia
Term
Gabapentin
Definition
Anti-seizure drugs used also for pain of neuropathic orgin
Term
N-acetylcysteine
Definition
Antidote for acetaminophen toxicity
Term
Flumazenil
Definition
Antidote to benzodiazepine overdose (antagonist that reverses the CNS effects)
Term
Protamine sulfate
Definition
Antidote to reverse actions of heparin
Term
N-acetylcysteine (Mucomyst)
Definition
Antidote used for acetaminophen (APAP) toxicity
Term
Flumazenil
Definition
Antidote used for benzodiazepine toxicity
Term
Naloxone (IV), naltrexone (PO)
Definition
Antidote used for opioid toxicity
Term
Vitamin and Fresh frozen plasma (FFP)
Definition
Antidote used for warfarin toxicity
Term
Thioridazine
Definition
Antipsychotic having the strongest autonomic effects
Term
Risperidone
Definition
Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia
Term
Drug induced Parkinsonism
Definition
Antipsychotics, reserpine at high doses, and MPTP (by-product of illicit meperidine analog) and is irreversible
Term
Risperidone
Definition
Atypical antipsychotic causing high prolactin levels
Term
Flumazenil
Definition
Benzodiazepine receptor antagonist, it accelerates recovery from benzodiazepine overdose
Term
Bleomycin
Definition
Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis
Term
Ipratropium
Definition
Bronchodilation in asthma and COPD
Term
Ace inhibitors
Definition
Captopril and enalapril (-OPRIL ending) are
Term
Atenolol, acebutolol, and metoprolol
Definition
Cardioselective Beta 1-blockers
Term
Verapamil
Definition
CCB contraindicated in CHF
Term
Red urine discoloration
Definition
Common side effect of Rifampin
Term
Testosterone
Definition
Converted to more active form DHT by 5 alpha-reductase
Term
Niacin
Definition
Decreases liver triglycerol synthesis
Term
Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively
Definition
Distribution of histamine receptors H1, H2, and H3
Term
Acetazolamide
Definition
Diuretic used for mountain sickness and glaucoma
Term
Spironolactone
Definition
Diuretic used to antagonize aldosterone receptors
Term
Spironolactone
Definition
Diuretic used to treat primary aldosteronism
Term
Rheumatic disease
Definition
DMARDs are slow acting drugs for
Term
Lithium
Definition
DOC for bipolar affective disorder
Term
Metronidazole
Definition
DOC for giardia, bacterial vaginosis, pseudomembranous colitis, and trichomonas
Term
Acyclovir and inhibits thymidine kinase
Definition
DOC for herpes and its MOA
Term
Amantadine
Definition
DOC for influenza A
Term
Dantrolene
Definition
DOC for malignant hyperthermia by acting on the sacroplasmic reticulum or skeletal muscle
Term
Dantrolene
Definition
DOC for malignant hyperthermia that may be caused by use of halogenated anesthetics
Term
Lidocaine
Definition
DOC for management of acute Ventricular arrhythmias
Term
Ribavirin
Definition
DOC for RSV
Term
Bromocriptine
Definition
Dopamine (DA) agonist (for Parkinson's disease), used also for hyperprolactinemia
Term
Bromocriptine
Definition
Dopamine agonist used in hyperprolactinemia
Term
Capsaicin
Definition
Drug causing depletion of substance P (vasodilator)
Term
Valproic acid
Definition
Drug of choice for myoclonic seizures
Term
Inhibit Cytochrome P450 3A4
Definition
Drug or foods (grapefruit juice) that increase statin effect
Term
Oxytocin
Definition
Drug that causes contraction of the uterus
Term
Vancomycin
Definition
Drug used for MRSA
Term
Ceftriaxone
Definition
Drug used for N. gonorrhea in females
Term
Dantrolene
Definition
Drug used in neuroleptic malignant syndrome
Term
Ethosuximide and valproic acid
Definition
Drugs of choice for absence seizures
Term
Valproic acid and Phenytoin
Definition
Drugs of choice for generalized tonic-clonic and partial seizures
Term
LSD
Definition
Ergot alkaloid used as an illicit drug
Term
Little C-peptide
Definition
Exogenous insulin
Term
Lipoprotein lipase
Definition
Fibrates (gemfibrozil) increase activity of
Term
Cimetidine
Definition
H2 blocker that causes the most interactions with other drugs
Term
Antithrombin 3
Definition
Heparin (PTT) increases activity of
Term
Bupropion
Definition
Heterocyclic antidepressants least likely to affect sexual performance, used for management of nicotine withdrawal, SE's include dizziness, dry mouth, aggravation of psychosis, and seizures
Term
Protease inhibitors
Definition
HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism
Term
Dopamine
Definition
Hormone inhibiting prolactin release
Term
Barbiturates, phenytoin, carbamazepine, and rifampin
Definition
Inducers of Cytochrome P450 (CYP450)
Term
Ace inhibitors
Definition
Inhibit angiotensin-converting enzyme (ACE)
Term
Zileuton
Definition
Inhibitor of lipoxygenase
Term
Cimetidine, ketoconazole, erythromycin, isoniazid and grapefruit
Definition
Inhibitors of CYP450
Term
Overdose of opioids
Definition
Leads to respiratory depression progressing to coma and death
Term
Torsades de pointes
Definition
Life threatening cardiac event that prolong QT leads to
Term
Prolongs QT interval
Definition
Limiting side effect of Quinidine
Term
Ultralente (humulin U)
Definition
Long acting insulin
Term
Calcium
Definition
Loops lose and thiazide diuretics retain
Term
Angiotensin receptor
Definition
Losartan and valsartan block
Term
REM is decreased
Definition
Major effect of benzodiazepines on sleep at high doses
Term
Kidneys
Definition
Major route of elimination for Lithium
Term
Dexrazoxane
Definition
May protect against doxorubicin toxic by scavenging free radicals
Term
Thyroid and steroid hormones
Definition
Mechanism of action (MOA) utilizes intracellular receptors
Term
Bradykinin
Definition
Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema
Term
Rifampin
Definition
Meningitis prophylaxis in exposed patients
Term
Geriatrics due to its CNS (depression) effects
Definition
Methyldopa is contraindicated in
Term
Mast cell stabilizer
Definition
MOA action of cromolyn
Term
Stimulates cGMP which leads to vascular smooth muscle relaxation
Definition
MOA and effect of nitric oxide
Term
Sodium channel blockers
Definition
MOA of class I A (eg. Procainamide), class IB (eg. Lidocaine), and class IC (eg. Flecainide) antiarrhythmics
Term
Relax vascular smooth muscle, at low doses dilate veins and at high doses dilate arterioles
Definition
MOA of nitrates
Term
Inhibits phosphodiesterase-5, enhancing effects of nitric oxide-activated increases in cGMP
Definition
MOA of sildenafil (Viagra)
Term
Inhibit dihydropteroate synthase
Definition
MOA of sulfonamides
Term
Degradation of fibrin clots and are administered
Definition
MOA of thrombolytics
Term
Insulin
Definition
MOA utilizes transmembrane receptors
Term
Codeine, hydrocodone, and oxycodone
Definition
Moderate opioid agonists
Term
LFT's
Definition
Monitoring parameter to obtain before initiation of STATINS
Term
Ipratropium
Definition
Muscarinic antagonist used in asthma
Term
Diethylstilbestrol (DES)
Definition
Non-steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy
Term
Indomethacin and phenylbutazone
Definition
NSAIDS used in gout
Term
Naloxone
Definition
Opioid antagonist that is given IV and had short DOA
Term
Naltrexone
Definition
Opioid antagonist that is given orally in alcohol dependency programs
Term
Fentanyl
Definition
Opioid associated with respiratory depression, but is used in high risk patients who may not survive full general anesthetia
Term
Fentanyl
Definition
Opioid available trans-dermally
Term
Morphine
Definition
Opioid that can be given PO, by epidural, and IV, which helps to relieve the dyspnea of pulmonary edema
Term
Methadone
Definition
Opioid used in the management of withdrawal states
Term
Mannitol
Definition
Osmotic diuretic used for increased intracranial pressure
Term
Lithium toxicity
Definition
Patients being treated with lithium, who are dehydrated, or taking diuretics concurrently, could develop
Term
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Definition
Pneumonic for beta receptors
Term
Na+/K+ exchange
Definition
Potassium sparing diuretics inhibit
Term
Atropine, homatropine tropicamide
Definition
Produce mydriasis and cycloplegia
Term
C-peptide
Definition
Product of proinsulin cleavage used to assess insulin abuse
Term
Alprostadil
Definition
Prostaglandin used in the treatment impotence
Term
Prostaglandin E1 (misoprostol) PGE2, and PGF2alpha
Definition
Prostaglandins that cause abortions
Term
Diphenhydramine and impromidine respectively
Definition
Prototype antagonist of H1 and H2 receptors
Term
Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin
Definition
PTU (propylthiouracil) MOA
Term
Changes in heart rate, blood pressure, respiration, body temperature, sweating, bowel signs, and pupillary responses
Definition
Readily detected markers that may assist in diagnosis of the cause of a drug overdose include
Term
Ability to cross the placenta
Definition
Reason benzos are used cautiously in pregnancy
Term
Beta-blockers
Definition
Reduce heart rate, contractility, and O2 demand
Term
Dry cough, hyperkalemia
Definition
SE of ACE inhibitors
Term
Paresthesias, alkalization of the urine (which may ppt. Ca salts), hypokalemia, acidosis, and encephalopathy in patients with hepatic impairment
Definition
SE of acetazolamide
Term
Orthostatic hypotension (especially with first dose) and reflex tachycardia
Definition
SE of alpha blockers
Term
GI bleeding
Definition
SE of Aspirin
Term
Bradycardia, SEXUAL DYSFUNCTION, decrease in HDL, and increase in Triglycerols (TG)
Definition
SE of beta blockers
Term
Constipation, edema, and headache
Definition
SE of CCB
Term
Lupus-like syndrome
Definition
SE of hydralazine
Term
Tremor, sedation, ataxia, aphasia, thyroid enlargement, and reversible diabetes insipidus
Definition
SE of lithium
Term
Adrenal suppression and weaning slowly, respectively
Definition
SE of long term (>5 days) corticosteroid therapy and remedy
Term
Hyperuricemia, hypokalemia and ototoxicity
Definition
SE of loop (furosemide) diuretics
Term
Cutaneous flush
Definition
SE of niacin
Term
Gingival hyperplasia, nystagmus, diplopia and ataxia
Definition
SE of phenytoin
Term
Lupus-like syndrome
Definition
SE of procainamide
Term
Gynecomastia hyperkalemia, and impotence
Definition
SE of spironolactone
Term
Hyperuricemia, hypokalemia and hyperglycemia
Definition
SE of thiazide (HCTZ) diuretics
Term
Prazosin, terazosin, doxazosin
Definition
Selective Alpha 1 blocker used for hypertension, BPH, may cause first dose orthostatic hypotension
Term
Acebutolol, atenolol, esmolol, metoprolol
Definition
SelectiveB1 Receptor blockers that may be useful in treating patients with asthma
Term
Hyperprolactinemia, menorrhea, galactorrhea, confusion, mood changes, decreased sexual interest, and weight gain
Definition
Side effects occuring in antipsychotics that block dopamine
Term
Thick ascending limb
Definition
Site of action of loop diuretics
Term
Work at early distal convoluted tubule
Definition
Site of action of thiazide diuretics
Term
Osteopenia, impaired wound healing, inc. risk of infection, inc. appetite, HTN, edema, PUD, euphoria, psychosis
Definition
Some side effects of corticosteroids
Term
Desmopressin (DDAVP)
Definition
Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis
Term
MEOS
Definition
System that increases in activity with chronic exposure and may contribute to tolerance
Term
Imipramine
Definition
TCA used in chronic pain, enuresis, and ADD
Term
Scotch tape technique
and mebendazole
Definition
Technique used to diagnose perianal itching, and the drug used to treat it
Term
Marijuana
Definition
THC is active ingredient, SE's include impairment of judgment, and reflexes, decreases in blood pressure and psychomotor performance occur
Term
Peripheral neuropathy (also excessive alcohol use is associated with HTN, anemia, and MI)
Definition
The most common neurologic abnormality in chronic alcoholics
Term
Ethanol, Barbiturates, and Benzodiazepines
Definition
These agents are CNS depressants
Term
Alpha1 agonists
Definition
These agents decrease blood flow or increase blood pressure, are local decongestant, and used in therapy of spinal shock (temporary maintenance of blood pressure which may help maintain perfusion
Term
Timolol (nonselective), betaxolol (selective)
Definition
These Beta blockers decrease aqueous secretion
Term
PTU
Definition
Thioamide less likely to cross placenta, inhibits peripheral conversion of T4 to T3 in high doses, and should be used with extreme caution in pregnancy
Term
Bethanechol
Definition
This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention
Term
Naloxone
Definition
This agent may cause more severe, rapid and intense symptoms to a recovering addict
Term
Timolol
Definition
This beta blocker lacks local anesthetic activity (decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
Term
Epinephrine
Definition
This is the drug of choice for anaphylactic shock
Term
Phase I
Definition
This step of metabolism makes drug more hydrophilic and hence augments elimination
Term
Pulmonary embolism and DVT
Definition
Thrombolytics are used for
Term
Half-life (T1/2)
Definition
Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs)
Term
Miosis and constipation
Definition
Tolerance to all effects of opioid agonists can develop except
Term
DUMBELSS (diarrhea, urination, miosis, bronchoconstriction, excitation of skeletal muscle and CNS, lacrimation, salivation, and sweating)
Definition
Toxicity of organophosphate:
Term
Benztropine, trihexyphenidyl
Definition
Treat manifestations of Parkinson's disease and EPS
Term
Rifampin, Isoniazid, Pyrazinamide, and Ethambutol
Definition
Treatment for TB patients (think RIPE)
Term
Scopolamine
Definition
Treatment of motion sickness
Term
Patches, gum, nasal spray, psychotherapy, and bupropion
Definition
Treatments available for nicotine addiction
Term
PGE1
Definition
Used in pediatrics to maintain patency of ductus arteriosis
Term
Calcitonin (salmon prep)
Definition
Used intranasally and decreases bone resorption
Term
Warfarin (PT)
Definition
Vitamin K dependent anticoagulant
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