Term
| These drugs disrupt cell wall synthesis and activate autolysins(enzymes that cleave bonds in the cell wall) |
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Definition
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Term
| Cephalosporins do their best work when bacterial cells are dividing or not dividing? |
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Definition
| When b. cells are undergoing ACTIVE cell growth and division |
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Term
| Are cephalosporins used for gram+ or gram- infections? |
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Definition
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Term
| T/F There are 4 generations of cephalosporins with INCREASING activity against GRAM- bacteria? |
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Definition
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Term
| The 2nd generation drug cefoxitin (Mefoxin) is used for what 3 infections? |
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Definition
Otitis (ears)
Sinusitus (sinus)
Respiratory(lungs) |
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Term
| What is the 3rd generation drug of choice for meningitis? |
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Definition
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Term
| What generation is the drug of choice for nosocomial infections resistant to other drugs? |
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Definition
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Term
| What is the resistance problem with cephalosporins? |
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Definition
| Bacteria produce beta-lactamase or cephalosporinase |
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Term
| In cephalosporins, which generations are better able to reach CSF? |
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Definition
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Term
| Are the 3rd and 4th generations of cephalosporins highly resistant to beta-lactamase? |
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Definition
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Term
| Are the 3rd and 4th generations of cephalosporins less sensitive to beta-lactamase? |
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Definition
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Term
| Are the first generations 'CEFS' susceptible to beta-lactamase? |
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Definition
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Term
| Are the 1st and 2nd generations of CEFs considered to be more sensitive to beta-lactamase? |
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Definition
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Term
| What is the best route for CEF's? |
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Definition
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Term
| Is it okay to give cephasporins to a patient with SEVERE penicillin allergies? |
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Definition
| NO, cross-sensitivity will produce a reaction |
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Term
| Is it okay to give cephasporins to a patient with MILD penicillin allergies? |
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Definition
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Term
| After a cephalosporin is given, what lab value should we check? |
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Definition
| PT & PTT because of increase in bleeding due to Vit K interference. CAUTION: PT's on blood thinners too |
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Term
| These adverse effects are associated with what drug? Allergic, bleeding, thombrophlebitis, colitis, nephrotoxicity |
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Definition
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Term
| What other drug given with cephalosporins will interfere with renal excretion of the ceph? |
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Definition
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Term
| If alcohol is ingested while on a cephalosporins & the pt experiences, N/V, flushing,sweating, and pain, what is this type of reaction called? |
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Definition
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