Term
| Do penicillins have a beta-lactam ring? |
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Definition
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Term
| What type of drug has this MOA: binds to bacterial cell wall, destroys it, & prevents synthesis of a new wall |
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Definition
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Term
| If no allergies, whom is it safe to administer penicillin to? |
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Definition
1.children
2.older adults
3. pregnant women |
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Term
| Will penicillin penetrate the Blood Brain barrier? |
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Definition
| no, not usually unless there is fever or the meninges is inflamed. |
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Term
| Which is Penicillin active against:(select all) gram + cocci, gram- cocci,gram + bacilli, gram - bacilli |
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Definition
Gram+ cocci
Gram+ bacilli
Gram-bacilli(but not all) |
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Term
| What are the 2 things to be aware of when dealing with penicillin? |
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Definition
patient ALLERGIES
drug RESISTANCE |
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Term
| Know these 8 allergic reaction symptoms when dealing with penicillin: |
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Definition
1.urticarial rash (hives)
2.flushing
3.diaphoresis (sweating)
4.palpatations
5.fever
6.arthralgia (joint pain)
7.myalgia (muscle pain)
8.respiratory distress |
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Term
| These sypmtoms are related to what type of allergic reaction: severe respiratory distress, hypotension, tachycardia, cyanosis, convulsions, unconscious |
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Definition
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Term
| What is this patient experiencing: They have been on penicillin for 10 days and now have a fever, arthritis, rash, itching, enlarged lymph nodes and generalized edema? |
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Definition
| Penicillin "serum sickness" |
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Term
| If a large dose of penicillin G is given, what side effect may occur? |
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Definition
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Term
| If there is too much penicillin in a patients blood levels & they are experiencing seizures, confusion, or hallucinations, they may be suffering from: |
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Definition
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Term
| What are normal potassium levels? |
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Definition
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Term
| If probenecid (used to treat gout or kidney stones) is given with penicillin, what happens to the penicillin? |
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Definition
| Its excretion is delayed, so the antibacterial effects are prolonged(Positive interaction) |
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Term
| If penicillin and an aminoglycoside are given in the same IV solution, what will happen? |
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Definition
The penicillin INACTIVATES the aminoglycoside
Should wait 2 hours |
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Term
| When is penicillin the most effective? |
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Definition
| When bacteria are rapidly growing. |
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Term
| Would tetracycline (bacteriostatic) inhibit or enhance the effects of penicillin? |
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Definition
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Term
| Name 3 penicillins that are penicillinase-resistant? |
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Definition
1. nafcillin
2.oxacillin
3.dicloxacillin |
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Term
| T/F Narrow spectrum penicillins are able to resist beta-lactamase produced by some bacteria. |
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Definition
| TRUE, however there is a bacteria (MRSA) that has become stronger than the penicillinase-resistant penicillins. |
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Term
| What is used to treat MRSA? |
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Definition
Vancomysin alone
Vancomysin w/ rifampin |
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Term
| Is Augmentin a broad spectrum or an extended spectrum penicillin? |
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Definition
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Term
| What does the clavulanic acid in Augmentin and the sulbactam in Unasyn do to the bacterial beta-lactamase? |
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Definition
| It inhibits the bacterial lactamase, making the penicillins stronger |
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Term
| Are these considered broad or extended spectrum penicillins: Ticarcillin, carbenicillin, piperacillin? |
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Definition
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Term
| In Zosyn, what is added to the piperacillin to render the bacterial-lactamase ineffective? |
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Definition
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Term
These nursing implications are for which drug:
1.Dose prescribed in units
2.For po, take w full glass water 1 hr before meals
3.Monitor BUN, Creatinine, I/O
4. Watch allergic reactions
5.Tell pt to report symptoms:itching,rash..
6.watch for fluid overload |
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Definition
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