Term
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Definition
| direct acting a1, a2, b1, b2 non-selective agonist. Causes increased bp. Interacts with b1 receptors to increase force of contraction (ionotrophic) and rate of contraction (chronotrophic). via a1 receptors vasoconstricts. Via b2 receptors may increase vasodilation in skeletal muscle. Used for: alaphalaxis, prolongation of local anesthetic action, cardiac arrest to restore rhythms. |
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Term
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Definition
| a1, a2, b1 non-selective direct agonist. may lead to a decreased heart rate because of the barorecptor reflex, but still have increased force of contraction. does not vasodilate skeletal muscle. use for: shock, low blood presure. Toxicities: severe HTN (close monitoring required), necrosis due to IV extravasation, reduced flow to kidney and intestines. |
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Term
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Definition
| b1, b2 selective direct agonist. positive chronotrophic and ionotropic effect on heart. Potent vasodilator via b2. causes increase in CO and decrease in blood pressure. Uses: In emergency situations, increase hr in patients with bradycardia or heart block. Toxicites: b1: palpitations, tachycardia, b2: flushing. Also: cardiac ischemia and arrythmias. |
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Term
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Definition
| b1 and alpha receptor agonist. b1: increases CO, ionotropic, chronotrophic. half life = 2 mins. IV admin. racemic mixture: + b1 agonist and a1 antagonist, - a1 agonist. Uses: short term for cardiac decompensation after heart surgery or for CHF. Toxicies: speeds AV node conduction and can cause ventricular ectopic activity. |
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Term
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Definition
| a agonist (a1>a2). non-catecholamine. long duration of action bc cant be hydrolized by COMT. Uses 1) dilate eyes 2) decongestant (bc vasoconstricts) 3) raise bp. Toxicity: exacerbate HTN |
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Term
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Definition
| = ma-huang. Direct: agonist of a and b receptors and Indirect agonist, increases NE release from nerve terminals. Also, raises bp. Uses: decongestant, bronchodilator for asthma (but now use b2 selective agonists), treat urinary incontinence. Toxicites: bad for BProstaticH. |
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Term
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Definition
| One of the 4 enantiomers of ephedrine. Decongestant. Can be used to make methamphetamine. |
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Term
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Definition
| D1 direct agonist. increased cAMP, vasodilation of kidneys and coronary beds. IV admin only. Uses: CHF, shock. Toxicites: from too much SNS activity. NVD, tachycardia, arrythmia, HTN, vasoconstriction, necrosis from extravasation |
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Term
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Definition
| CNS effects: elevate mood and depresses apetite. Peripheral: indirect agonist by releasing NE. |
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Term
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Definition
| a2 selective agonist in CNS. decreses SNS outflow from CNS. Uses: treat HTN. |
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Term
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Definition
| b2 selective agonist. Used for asthma: bronchodilation, but also no tachycardia bc b1 is not activated. |
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Term
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Definition
| Food-drug intactions. Found in aged cheeses and wines. metabolite of tyrosine metabolism. Indiect agonist: causes NE release. In presence of MAOIs, cant be metabolized, so elevates bp so much that blood vessels in brain can burst. |
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