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Pharm IM Arrhythmia
KYCOM Block 13
134
Medical
Graduate
01/30/2014

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Cards

Term
what is the most common supraventricular arrhythmia
Definition
PAC
Term
describe EKG in premature atrial contraction, cause
Definition
until early P wave/ORS (hides normal P in it) followed by pick back up of sinus
SA node is resetting
Term
TX PAC 3
Definition
asymptomatic- none
BB, type Ic
Term
describe EKG in premature junctional complex, cause
Definition
sinus rhythm followed by premature abnormal P wave (upside down or hidden) and QRS with wide S

complex originates from AV node/His
Term
Tx premature junctional complex 2
Definition
BB
type IC anti arrhythmics
Term
cause of physiological sinus tachycardia 5
Definition
pain, exercise, fever, anxiety, hypotension, anemia
Term
cause of inappropirate sinus tachycardia
Definition
increase HR with normal activity due to SNS increase, PNS decrease, viral illness causing autonomic dysutonomia
Term
signs of inappropirate sinus tachycardia
Definition
palpitations, CP, GI upset, syncope
Term
TX inappropirate sinus tachycardia 2
Definition
asymptomatic - none
BB
Term
describe the EKG for AFib
Definition
irregular irregular
rapid ventricles 120-160, atria 500
fine fibrillations of P waves with irregular random QRS
Term
physiology of AFib, complications
Definition
atria automaticity and reentry mostly at atria and pulmonary veins

blood pools and clots in atria apendages and causes thrombus and stroke
Term
causes of AFib 6
Definition
acute hyperthyroid
acute alcohol/drugs
post-op
coronary disease
SVA - AV reentry
increases with age 5%>75yo
Term
signs of AFib 6
Definition
asymptomatic
fatigue
SOB
syncope
exercise intolerance
palpitations/angina
Term
risk factors for stroke 8
Definition
valve disease
mechanical valve
previous thromboembolism
heart failure
systole dysfunction
HTN
DM
age
Term
explain the CHAD2 score scoring and what treatment it correlates with
Definition
CHF, HTN, DM, >75yo = 1
previous stroke/TIA = 2

0= no therapy / aspirin
1= aspirin / warfarin
2 = warfarin / thrombin inhibitor
Term
what drug is a trombin inhibitor
Definition
clopdegril
Term
how is asymptomatic AFib treated
Definition
if <100BPM then give anticoag according to CHAD2

if >100bph then try BB, CCB, digoxin. if this dosent work try antiarrhythmic...
A: if has CAD then amioderone, soditol, dofetilide
B: if has LV dysfunction, tachy, cardomyopathy then use limited soditol
C: if has LVH/HTN then use fleconide or class 1C

if this dosent work ablate
Term
how is symptomatic stable AFib treated
Definition
IV heparin +
amiodorine, drocamamide, or dofetilide ibuilid

maintain with direct thrombin inhibitor 1 mo
CCB, BB, or digoxin to control ventricle rate
quinidine or disopyramide

if this dosent work ablate
Term
how is symptomatic unstable AFib treated
Definition
IV heparin
TEE if >24h
synch cardiovert biphasic 200J

maintain with direct thrombin inhibitor 1 mo
CCB, BB, or digoxin to control ventricle rate
quinidine or disopyramide

if dosent work ablate
Term
when do you ablate, 3 types
Definition
when all TX dosent work
when LV problems occur

focus: ablate near pulmonary veins

AV: eliminate and put in pace maker

coxmaze: ablate all reentry spots
Term
describe an EKG in AFlutter / microreentrant atrial tachycardia
Definition
regular irregular
atria 200-300
ventricles 130-150
less tolerated than AFib

spiked P waves with regular ventricle contraction between many
Term
descirbe a multifocal atrial tachycardia EKG
Definition
P waves with at least 3 different morphlogies
Term
cause of multifocal atrial tachycardia 2
Definition
pulmonary or septic infection
Term
TX multifocal atrial tachycardia 2
Definition
tx illness
CCB
Term
what do you never use in multifocal atrial tachycardia 4
Definition
BB
amioderone
flecinide
propefanone
Term
what does a AV reentry tachycardia / proxysmal supraventricular tachycardia look like, cause
Definition
rate 150-250
atria and vantricles both contract
retrograde P waves

AV node has two pathways: 1 slow, 1 fast. current goes doen slow and up fast
Term
cause PST
Definition
teens - 30s
alcohol, drugs, excitement
no underlying heart disease
Term
prevention of PST 3
Definition
avoid trigger
ablation
B/Ca blocker
Term
TX PST 3
Definition
1. vasovagal
2. IV adensine or IV class IV
3. maintience: CCB, BB, digoxin
Term
what does an accelerated junctional rhythm EKG look like, cause
Definition
50-99
depolarization near the AV node or on it
abnormal P waves or none
Term
cause accelerated junctional rhythm 2
Definition
digitoxin toxicity
ablation of SA
Term
TX accelerated junctional rhythm 3
Definition
correct toicity
class 1A or 1C
Term
causes or arrhythmia 7
Definition
Hypoxia- copd
Ischemia + irritability
Sympathetic
Drugs- BB, digoxin, cocaine
Electrolyte- dec K, inc Ca
Brady/tachy
Stretch- LVH/HTN
Term
explain the ion movements in the 4 phases of cardiac muscle contraction
Definition
4. K leaks out
0: Na rush in
1: Na slows, K rush out
2: K rush out, Ca rush in
3: K rush out
4: K leaks slowly
Term
explain the state of the Na gates in cardiac muscle contraction
Definition
4: resting - resting
0: M gates open - open
1: H gates close - absolute/effective refractory, inactive
2: absolute/effective refractry
3: switches mid phase to relative refractory
4: resting
Term
explain the ion movements in the phases of SA/AV contraction
Definition
4: Na leaks slowly in
0: Ca rushes in
3: K rushes out
4: Na leaks in
Term
explain how to read the boxes on EKG
Definition
1 little = 0.04s
1 big = 0.2 sec, 0.5mV

2 big = 1mV
5 big = 1 sec

30 big = 6 sec
# peaks x 10 = rate
Term
define sinus pause
Definition
stops for >1 beat (3 sec is ok in athlete)
Term
define sinus exit block
Definition
stops for 1 beat
Term
define sick sinus
Definition
brady/tachy alternating
Term
define state dependent
Definition
channel blocking dosent work well in resting (4)
Term
what causes DAD 4
Definition
Ca overload
SNS
digitoxin
MI
Term
what causes EAD
Definition
dec HR
de K
prolonged 3
prolonged QT
Term
what can EAD lead to
Definition
torsades
Term
what are the three conditions needed for reentry
Definition
1. obsticle
2. unidirectional block
3. long enough to outlast refractory
Term
why are reentrys scary for pt
Definition
AFib will be accelerated if it happens and cause m ore deterioration
Term
how does a WPW EKG look
Definition
PR>0.12
wide QRS
D waves in some leads
consistantly abnormal P waves
Term
what pathway does WPW take
Definition
bundle of kent
Term
what pathway does lown ganong levine take
Definition
james fiber (intranodal)
Term
what does lown ganong levine EKG look like
Definition
PR<0.12, normal QRS
Term
how is a reentry treated 4
Definition
vasovagal
IV adenosine or diltzem
maintience: BB, CCB, digoxin, fleccanide, procamide
Term
how is a person with reentry in AFib treated
Definition
1. cardiovert
2. procanamide, ibutalide, amioderone
Term
what does a 1st deg AV block look like
Definition
slowed conduction through node and tissue
common, asymptomatic, PR>200ms
Term
what does a mobitz type 1 (wenchebach) look like
Definition
usually benign
block on or by node
progressive lengthening of PR until one is dripped
Term
what does a mobitz type II look like
Definition
block below AV node can progress to 3rd deg
may need pacemaker
consistant PR interval until one is dropped
Term
what does a 3rd deg AV block look like
Definition
AV dissociation, ventricles and atrial are independent
block at AV, upper BB, lower BB
ventricles 30-45
atria 60-100
Term
causes of AV block 4
Definition
autnomic- vasovagal
lyme, chagas, sphyilis
metabolic: ince K, dec adrenal
drugs: digoxin, CCB, adenosine
Term
TX AV block
Definition
type 1: none or atropine/epi/amnioderone

type 2: atropine/eip/amnioderone

type 3: atropine/epi/amnioderone or pacemaker
Term
what does a EKG for premature ventricular complex look like, cause
Definition
normal sinus with an out of place wide QRS, hides P wave
comes from purkinje
compensatory pause
Term
3 types of PVC
Definition
bigeminy: sinus/PVC/sinus/PVC/snus
tigeminy: sinus/sinus/PVC/sinus/sinus/PVC
pair/couple: sinus/PVC/PVC/sinus/PVC/PVC/sinus
Term
what increases risk of PVC 3
Definition
age
heart disease
Term
what should you NEVER take with a PVC
Definition
antiarrhythmics = DEATH prolong QT
Term
what is a complication of PVC
Definition
VTach
Term
tx PVC 2
Definition
asymp- nothing
symp- BB, K channel blocker
Term
describe the 2 kinds of VTach EKG
Definition
monomorphic: large repeating, regular QRS
polymorphic: oscilating sizes of QRS
Term
cause VTach
Definition
origin below bundle of His sustained
Term
2 classificationsof VTac
Definition
sustained: >30sec, >3PVC
nonsustained: <30sec
Term
what drugs should you NEVER use in VTach 2
Definition
verapmil
adenosine
Term
how is someone who is stable with VTach tx
Definition
satolol
amoderone
phenytoin
lidocaine - MI
propafenene

cardiovert - synch

maintain: quinidine, phenytoin, mexiletine-MI, dysopramide, sotalol
Term
how is someone who is unstable with VTach tx
Definition
cardiovert

maintain: quinidine, phenytoin, mexiletine-MI, dysopramide, sotalol`
Term
describe the 2 EKG types for VFib
Definition
coarse: spiky fibrillations
fine: small fibrillations
Term
VFib: 2 types, tx, effect in blood
Definition
no CO
primary: no CHF
secondary: with CHF
TX: asnch cardiovert
Term
what is the cause of long QT syndrome
Definition
defect in cardiac ion channel causing repolarization and prolonged plateau
Term
TX prolonged QT syndrome
Definition
implant defiv ig hx arrahytmic or syncope
avoid long QT drugs
Term
drugs with long QT
Definition
erythromycin
clathromycin
procanamide
quinidine
flecanide
sotalol
amioderone
Term
signs of tachycardia
Definition
syncope
CP dizzy
dyspnea
Term
evaluation of tachycardia
Definition
EKG
24h holder
telemetry
electrophysiolgy
ECHO stress test
Term
causes of bradhycardia
Definition
autonimic dysruption
sick sinus syndrome
hypothyroid
hypotension
hypothremia
physiological - athlete
inflammatory - pericarditis
structural heart disease - CAD
vasovagal
BB
CCB
digoxin
lithium
methadone
K channel blocker
Term
MOA class 1 drugs
Definition
block Na channels in abnormal high frequency rhythms
affinity for open/inactive channels
Term
MOA of class 1 A-C, half life
Definition
A: N and K block, 1-10sec. increase ERP, supress 0

B: Na block. decrease ERP, increase ) slope.

C: Na, Ca, K blocker. depress slope 0, decrease max depolarization
Term
explain how the class 1A-C graph looks
Definition
A: lengthens 0 slope, lower plateu height, elongated 3

B: lengthens 0 slope less than A, shortens 3

C: lengthens 0 slope most, shortens plateau height
Term
class 1A drugs 3
Definition
quinidine
procanamde
disopyramide
Term
class 1B drugs 3
Definition
lidocaine
mexiletine
phenytoin
Term
class 1C drugs 3
Definition
flecanide
propafenone
Term
class 2 MOA
Definition
B adrenergic agonist
lengthen (decrease) slope of 0 and 4 (shift right)

decrease automaticity at SA, HR, CO
lengthen PR
Term
what drugs decrease mortality in arrhythmia pt
Definition
B blockers
Term
4 B blockers used for arrhythmia and when
Definition
propanolol, atenolol, metoprolol: decrease sudden cardiac death after MI arrhythmia

esmolol: shor tacting, IV acute arrhythmia
Term
why is esmolol short acting
Definition
metabolized by RBC t1/2 9 min
Term
MOA Class 3 drugs
Definition
K channel blockers
elongaed ERP
Term
class 3 drugs 5
Definition
sotalol
amiodarone
dronedarone
dofetilide
ibutilid
Term
class 4 drugs MOA
Definition
Ca channel blockers
increase slow of 0, elongate ERP
increase AV.SA conduction

block inactive and active Ca channels mostly at SA/AV node
increase PR due to AV delay
Term
2 CCB
Definition
verapamil
ditazem
Term
dofetilide/ibutilid: administration, use, SE
Definition
IV acute
NOT for long duration AFib/Flutter they dont respond
SE torsades

USE: drug cardiovert in WTD arrhythmia, AFib, AFlut
Term
amiodarone, dronedarone MOA
Definition
blocks Na, Ca, K
increases QRS, PR, QT
Term
SE amniodarone, droendarone
Definition
sinus brady
PULMONARY ACEOLITIS/FIBROSIS
hepatotoxicity
photosensitivity
thyroiditis/blue skin- amioderone
Term
use: amniorarone, droendarone
Definition
ANY supraventricular tachycardia drug cardiovert: AFib/flut (ok with CAD), VTac, AV Block, WPW tachyarrhythmia
Term
sotaolol MOA
Definition
prolong QT
ERP prolong
B blocker dec SA automaticity
Term
SE sataolol
Definition
EAD
bradycardia
dyspnea
fatigue
torsades
Term
USE satalol
Definition
MOST MI
maintance post-VTach
drug cardiovert- VTach, LV dysfunction and CAD asymp AFib/Flut
Term
quinidine: MOA
Definition
antimalaria
anti-M inc HR
a1 blocker dec HR and cause hypotension and long PR
widen QRS and QT
Term
SE quinidine
Definition
mortality in non life threat arrhythmia
hypertension
vertigo
tinnutis
headache diarrhea
torsades
AFib/flutter (due to dec K)
hypokalemia
Term
procanamide MOA
Definition
shorted t1/2
acetylated to NAPA which blocks K
Term
SE procanamide
Definition
mortality in non-life threat arrhythmia
hypotension
lupus like due to NAPA acetylation
torsades (hypokalemia)
Term
disopyramide: administration, MOA
Definition
oral
anti-M dec HR
decrease PR interval
Term
disopyramide SE
Definition
mortality in non life threat arrhythmia
hypotension
glaucoma
dry mouth
urinary retention
constipation
torsades
Term
MOA lidocaine
Definition
local anastetic decreases automaticity in purkinje blocking NA
Term
lidocaine administration and exretion
Definition
IV high first pass
eliminated in liver
Term
SE lidocaine
Definition
drowsiness
slurred speech
confusion
convlusions
Term
administration and MOA mexiletine
Definition
oral lidocaine
Term
SE mexiletine
Definition
tremor, nausea
Term
MOA phenytoin
Definition
anticonvulsant
blocks NA and purkinke
Term
SE phenytoin
Definition
vertigo confusion, gingival hyperplasia
P450 inducer
Term
MOA flecanide
Definition
effects normal heart
prolongs AP in atria and ventricles
inc PR, QRS, QT
Term
SE flecanide
Definition
mortality in ventricle arrhythmia
blurred vision
dizzy
headache
Term
MOA propafenone
Definition
flecanide for life threatning ventricular arrhythmias
Term
SE proparfenone
Definition
increased mortality in non life threating arrhythmia
Term
use quinidine
Definition
accelerated junctional rhythm
maintience VTach/VFib
maintience AFib/Flut
Term
use procanamide
Definition
accelerated junctional rhythm
drug cardiovert WPW arrhythmia
maintain WPW
Term
use disopyramide
Definition
accelerated junctional rhythm
maintain AFib/Flut
maintain VFib/Tach
drug cardiovert WPW arrhythmia
Term
use lidocaine
Definition
chem cardiovert VTach/Fib MI
Term
use melixetine
Definition
maintain aftr VTach/Fib MI
Term
use phenytoin
Definition
maintain aftr VTach/Fib MI
chem cardiovert VTach/Fib MI
Term
use of class 1C
Definition
premature atrial contraction
junctional premature complex
not responding asymptomatic AFib/Flutter with HTN/LVH
accelerated junctional rhythm
proprafenone: cardiovert VTach/Fib
Term
use of BB
Definition
prematyre atrial contraction
junctional premature complex
inappropirate sinus tachycardia
maintain AFib/Flut
maintain PST/AV reentry
dec symp ot PVC
maintain WOW
Term
use of CCB
Definition
maintain AFib/Flut
multifocal atrial tachycardia
PST/AV reentry
maintain WPW
Term
MOA digoxin
Definition
increase aytomaticity
increase refractory in opurkinjue
decrease refractory in ventricles and atria
parasympathetic via vagus increases PR and and dec conduction
Term
SE digoxin
Definition
increased CA and automaticity causes DAD
extra systole
tachycardia
PVC
fibrillation
visual changes (yellow)
Term
use digoxin
Definition
maintain AFib/Flut
maintain PST
maintain WPW
VTACH PROPHYLAXIS
Term
MOA adenosine
Definition
high dose activates Gi decreasing Ca current decreasing conduction velocity increasing ERP decreasing AV velocity
t1/2 8sec must be IV bolus
Term
SE adenosine
Definition
flushing, CP, hypotension
Term
use adenosine
Definition
DOC IV bolus supraventricular tachycardia
PST/AV reentry
WPW
Term
MOA K ions
Definition
decrease ectopic pacemakers
esp from digitalis
Term
SE K ions
Definition
reentry arrhythmias
Term
MOA Mg ions
Definition
stops digitalis arrhythmia and torsades
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