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Pharm II
Respiratory
22
Pharmacology
Graduate
10/29/2014

Additional Pharmacology Flashcards

 


 

Cards

Term
Drugs used to treat acute and chronic asthma :
Definition

B2 adrenergic agonists

corticosteroids

cromolyn and nedrocromil

cholinergic antagonists

theophylline

anti-leukotries

omalizumab

Term
Drugs used to treat allergic rhinitis :
Definition

antihistamines (H1 receptor blockers)

alpha - adrenergic agonists

corticosteroids

cromolyn

montelukast

Term
Drugs can be delivered to thelungs through the following routes
Definition

inhalation

oral

parenteral

Term
______ is often the preferred route because the drug is delivered directly to the airways so it can be given at lower doses resulting in fewer systemic side effects
Definition
inhalation
Term
chronic inflammatory disorder of the airways that affects 7% of the US population (male and female)
Definition
asthma
Term

Not usually a progressive disease

characterized by episodes of acute bronchoconstriction, bronchial inflammation, and increased mcuous secretion

Definition
asthma
Term
Mild asthma
Definition

< 2 attacks/week

inhaled short acting B2 - adrenergic agonists

low-dose inhaled glucocorticoids

Term
moderate asthma
Definition

> 2 attacks/week

inhaled short acting B2 adrenergic agonists

low to medium dose inhaled corticosteorids

long acting B2 - adrenergic agonist

Term
severe asthma
Definition

daily attacks

inhaled short acting B2 - adrenergic agonists

high dose inhaled glucocorticoids (ADT)

long acting B2 - adrenergic agonists

Term
Bronchial dilators
Definition

B2 adrenergic agonists

theophylline

ipratropium

Term
Anti-inflammatory agents
Definition

glucocorticoids

cromolyn

anti-leukotrienes - cause bronchoconstriction

Term
DOC for mild asthma
Definition

rescue agents

inhaled adrenergic agonists with B2 activity

Term
Are B2 agonists catecholamines?
Definition
No, NO COMT metabolism
Term
DOC for acute anaphylaxis
Definition
epinephrine
Term
Terbutaline
Definition

rapid onset - 15-30 minutes

relatively long duration of action (up to 6 hrs)

can be given orally, inhalation, or SQ

used for bronchodilation in asthma

Term
this drug also decreases uterine contractions in premature labor (tocolytic)
Definition
terbutaline
Term

can be taken through inhalation or orally

 

Definition
albuterol
Term
usually given via inhalation route
Definition
pirbuterol
Term
B2 adrenergic agonists - Long acting drugs
Definition

salmeterol, formoterol

do not give for acute relief

Term
chemical analog of albuterol - bronchodilator
Definition

salmeterol xinafoate

formoterol

Term
Salmeterol xinafoate & Formoterol
Definition

long duration of action - up to 12 hours

slow onset of action

NOT for acute asthma attacks

given prophylactically at regular intervals with steroids

NOT a substitue for anti-inflammatory therapy 

Term
tachycardia, hyperglycemia, hypokaleia, kypomagnesemia, skeletal muscle tremors, tolerance, hypoxemia
Definition
B2 adrenergic agonists - AE
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