Term
How does Amphotericin B (Fungizone)
work? |
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Definition
| Binds to sterols in fungal cell membranes. This weakens the structure causing cell leakage and death. |
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Term
| If treating a fungal infection that is in the CNS how must Amphotericin B (Fungizone) be administered |
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Definition
| Must be given intrathecally for CSF infections |
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Term
| What is Amphotericin B (Fungizone) used to treat? |
|
Definition
Antifungal agent for systemic fungal or protozoal infections.
Available IV or through topical ointments |
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Term
What pts should you use caustion with when giving Amphotericin B (Fungizone)
Why? |
|
Definition
patients with hypokalemia, hypomagnesemia and anemia
as amphotericin B can exacerbate this.
Renal patients-Nephrotoxicity |
|
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Term
What are the common side effects of Amphotericin B (Fungizone)
3 |
|
Definition
infusion reactions
electrolyte imbalances
anemia |
|
|
Term
| What are the most serious side effects of Amphotericin B (Fungizone) |
|
Definition
| Nephrotoxicity seen as azotemia: renal tubular acidosis and renal failure. |
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Term
| Why should a nurse not give Amphotericin B (Fungizone) along with NSAIDS? |
|
Definition
The nurse knows not to administer with other nephrotoxic drugs |
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Term
Pts on Amphotericin B (Fungizone) should be placed on fluid restictions.
True or False? |
|
Definition
False
Keep patients well hydrated to decrease risk of Nephrotoxicity |
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|
Term
| What education should the nurse give to the pt reciving Amphotericin B (Fungizone) at home? |
|
Definition
Trick question
It is only Administered in an acute care environment |
|
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Term
A pt is being treated with Amphotericin B (Fungizone)
for an acute infection and takes digitalis QD.
What is the nurses best action for this pt?
Why? |
|
Definition
assess for hypokalemia
Amphotericin B may induce hypokalemia, which increases the risk for digitalis glycoside toxicity. |
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Term
A pt is to be treated with Amphotericin B (Fungizone).
What labs is the nurse most concered about? |
|
Definition
| electrolytes, CBC, Renal and Liver labs |
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Term
| What is Fluconazole (Diflucan) used to treat? |
|
Definition
Esophageal or oropharyngeal candidiasis
candida vaginitis
disseminated candidiasis
cryptococcal meningitis |
|
|
Term
| How does Fluconazole (Diflucan) work? |
|
Definition
| Alters fungal cell membrane, leading to increased cellular permeability and leakage. |
|
|
Term
| What types of pts need extra caution when giving Fluconazole (Diflucan) |
|
Definition
| pregnancy and existing hepatic and renal dysfunction |
|
|
Term
| A pt is taking Fluconazole (Diflucan), what adverse effects should the nurse plan for? |
|
Definition
Diarrhea, nausea and vomiting
Administer an antiemetic or antidiarrheal agents |
|
|
Term
| What labs are commonly elevated while on Fluconazole (Diflucan) |
|
Definition
| Elevation in AST, ALKP, Bilirubin |
|
|
Term
| What serious side effect should the nurse be assessing for in a pt taking Fluconazole (Diflucan) |
|
Definition
Stevens-Johnson syndrome- an exfoliative skin disorder
assess for skin rash, redness, pealing skin |
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Term
What pt needs further education when taking Fluconazole (Diflucan).
A. A pt who takes the drug with food
B. A pt who drinks alcohol daily
C. A pt who takes aspirin daily
|
|
Definition
B. A pt who drinks alcohol daily
Take the drug with food if GI distress experienced.
Do not ingest alcohol, will increase risk of hepatotoxicity.
Use aspirin instead of acetaminophen for discomforts due to affects of Tylenol on the liver. |
|
|
Term
1. There are lots of things to know before giving amphotericin B. What are some of the precautions? Are there any administration considerations? What labs need to be monitored? |
|
Definition
Check pt for hypokalemia, hypomagnesemia and anemia
· Do not reconstitute with a bacteriostatic agent
· Monitor electrolytes, CBC, Renal Labs
Monitor hematopoietic and renal systems
|
|
|
Term
A patient receiving diflucan calls the nurses station complaining of a headache. He has aspirin and Tylenol order, what is the best action? |
|
Definition
| Use aspirin instead of acetaminophen for discomforts due to affects of Tylenol on the liver. |
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Term
What are some drug interactions of acyclovir? |
|
Definition
| This medication can interact with probenicid and zidovudinr |
|
|
Term
What assessment data gathered after administration of IV Acyclovir would indicate that the client is NOT suffering from adverse effects? How do you monitor for toxicity. |
|
Definition
Norm LOC
Assess for seizures, coma
|
|
|
Term
What is your response when your pt says they can't give the virus to partner because they're on acyclovir? |
|
Definition
| educate pt on how the virsus is spred. They are still able to spred it to others. |
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Term
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Definition
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