Term
| What meds are NSAIDs? (I.D.I.N.S.O.) |
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Definition
Ibuprofen,
Diclofenac,
Indomethacin
Naproxen
Sulindac
Oxaprozin |
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Term
| What med is a reverse inhibitor of COX 1 and 2? What is the result of this inhibition? |
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Definition
| Ibuprofen: reduction in prostaglandin synthesis (leading to anti-inflammatory effect) |
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Term
| Since there is decreased PGI2 synthesis with Ibuprofen use, what results as a SE of this drug? |
|
Definition
| Increased gastric Acid secretion and increase in gastric ulcers |
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Term
| What two conditions are the anti-inflammatory properties of ibuprofen especially useful in? |
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Definition
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Term
| What is the difference between Ibuprofen and ASA's mode of action? How does this affect platelets? |
|
Definition
ASA IRREVERSIBLY inhibits COX 1 & 2 while Ibuprofen REVERSIBLY inhibits COX 1 & 2
Because of ASA's IRREVERSIBLE inhibition, the production of platelets is diminished and thus the aggregation of platelets is decreased, where as Ibuprofen only REVERSIBLY inhibits COX 1 & 2 giving platelets time to rebound and thus not effecting platelet aggregation. |
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Term
| What med is used especially in the treatment of gout and OA? |
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Definition
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Term
| What effect can Indomethacin have on labor? |
|
Definition
| decreases uterine contractions thus suppressing labor |
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|
Term
| What cardiac defect can be treated with indomethacin? |
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Definition
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Term
| What med has major SE including GI bleeding and interstitial nephritis, as well as tinnitus and hepatitis? |
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Definition
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Term
| What med irreversibly inhibits COX 2, thereby resulting in decreased Prostaglandin synthesis which generally leads to an anti-inflammatory effect? |
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Definition
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Term
| What med is used in the tx of OA and RA as an anti-inflammatory drug, but has a lower risk of GI bleed SE? |
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Definition
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Term
| What anti-inflammatory med can be used in the treatment of familial adenomatous polyposis? |
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Definition
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Term
| What anti-inflammatory med can lead to an increased risk of thrombosis (eg stroke and heart attack)? |
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Definition
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Term
| What med irreversibly inhibits COX 2 and was used to treat arthritis and chronic pain, but had to be taken off the market in 2004, b/c of the SE of increased risk of heart attack and stroke with this drug? |
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Definition
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Term
| What med irreversibly inhibits COX 1 and 2? |
|
Definition
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Term
| What med acts to reversibly inhibit COX 1 & 2 in the CNS thereby leading to decreased prostaglandin synthesis in the CNS, but is largely inactivated peripherally? |
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Definition
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Term
| Which has more anti-inflammatory effects, acetaminophen or ibuprofen? |
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Definition
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Term
| What med can be used in children who have a viral illness as an anti-pyretic? |
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Definition
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Term
| What med can cause fatal hepatotoxicity with overdose? |
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Definition
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Term
| What is the antidote for acetaminophen overdose? |
|
Definition
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|
Term
| What is the 1st line DMARD used to treat RA? |
|
Definition
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