Term
| Which ergot alkaloids are used to decrease lactation |
|
Definition
| Bromocriptine & Methylergonovine |
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|
Term
| Which ergot alkaloids are used to treat post-partum hemorrhage? |
|
Definition
| Ergonovine & Methylergonovine |
|
|
Term
| Which 3 ergot alkaloids are used to treat migraine headaches? |
|
Definition
Dihydroergotamine
Ergotamine Mixture (Cafergot)
Ergotamine tartrate |
|
|
Term
| What are some SE of ergot alkaloids? |
|
Definition
GI irritation - N/V/D
Vasospasm
Drowsiness
Uterine stimulation (especially potent during pregnancy)
Hallucinations and Dementia |
|
|
Term
| With what disease are ergot alkaloids contraindicated? |
|
Definition
| Obstructive vascular disease & Collagen Disease |
|
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Term
| Which prostaglandins inhibits aggregation of platelets? |
|
Definition
| PGD and high concentration of PGE |
|
|
Term
| What effect does the prostaglandin PGE have on vessels? |
|
Definition
|
|
Term
| What effect does the prostaglandin PGF have on vessels? |
|
Definition
| Promotes Vasoconstriction |
|
|
Term
| What effects do the prostaglandins have on Respiratory Smooth muscle? |
|
Definition
PGD - Contracts
PGE - Relaxes
PGF - Contracts |
|
|
Term
| What effect does the prostaglandin PGE have on the uterus? |
|
Definition
High [ ] of PGE = promoting relaxation
Low [ ] of PGE = contraction of uterus |
|
|
Term
| What effect does the prostaglandin PGF have on the uterus? |
|
Definition
|
|
Term
| What effects do the prostaglandins have on the gastrointestinal tract? |
|
Definition
| All Activate the GI tract |
|
|
Term
| Which prostaglandins have an effect on the IOP, and what effect do they have? |
|
Definition
|
|
Term
| Which prostaglandin has an effect on the kidney, and what is its effect? |
|
Definition
| PGE - decreases renin, which leads to an excretion of H20 and Na which causes a reduction in BP |
|
|
Term
| Which prostaglandin stimulates aggregation of platelets? |
|
Definition
| Low [ ] of PGE causes aggregation |
|
|
Term
| Which prostaglandin enhances penile erection? |
|
Definition
|
|
Term
| Which prostaglandin increases bone turnover? |
|
Definition
|
|
Term
| Which prostaglandins induce fever? |
|
Definition
|
|
Term
| What effect does thromboxane have on the vessels? |
|
Definition
|
|
Term
| What effect does thromboxane have on platelets? |
|
Definition
|
|
Term
| What effect does thromboxane have on respiratory smooth muscle? |
|
Definition
|
|
Term
| What effect does thromboxane have on the uterus? |
|
Definition
| Contraction of the uterus |
|
|
Term
| What effect does thromboxane have on on the GI system? |
|
Definition
|
|
Term
| What effect does thromboxane have on the kidneys? |
|
Definition
| Increases renin production, leading to H2O and Na retention which causes a rise in BP |
|
|
Term
| What effect does prostacyclin (PGI) have on the vessels? |
|
Definition
|
|
Term
| What effect does prostacyclin (PGI) have on the platelets? |
|
Definition
|
|
Term
| What effect does prostacyclin (PGI) have on the respiratory smooth muscles? |
|
Definition
|
|
Term
| What effect does prostacyclin (PGI) have on the uterus? |
|
Definition
| Promotes uterine relaxation |
|
|
Term
| What effect does prostacyclin (PGI) have on the GI tract? |
|
Definition
|
|
Term
| What effect does prostacyclin (PGI) have on the kidneys? |
|
Definition
| Increases renin production, leading to H2O and Na retention which causes a rise in BP |
|
|
Term
| What effect do leukotrienes have on the respiratory smooth muscle? |
|
Definition
| Bronchoconstriction and mucous production |
|
|
Term
| What enzyme do NSAIDs inhibit? What effect does this have? |
|
Definition
| Inhibits COX-1 and COX-2, which causes a decrease in inflammation |
|
|
Term
| Which 2 meds are inhibitors of COX-2 enzyme? Which is the most potent? |
|
Definition
Celecoxib (Celebrex) - most potent
Diclofenac (Voltaren) |
|
|
Term
| Which two meds are COX-1 inhibitors? |
|
Definition
| Indomethacin and Sulindac |
|
|
Term
| What effects do the leukotrienes (LTC, LTD and LTE) have on the body? |
|
Definition
Inflammation
Mucous Production
Bronchoconstriction
Cardiac Depression |
|
|
Term
| What effects does DHET have on the body? |
|
Definition
| Inflammation and Vasodilation |
|
|
Term
| Which med irreversibly blocks COX-1 and COX-2? |
|
Definition
|
|
Term
What is Bartter's Syndrome caused by?
What are it's results?
How is it treated? |
|
Definition
Increased synthesis of Prostaglandins
Results in low to normal BP, decreased sensitivity to angiotensin, hyperreninemia, hyperaldosteronism, excessive K excretion, excessive secretion of prostaglandins in the urine
Treated by giving COX inhibitors |
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