Term
what is the general order for tx htn 12 |
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Definition
thiazide diruetic ACE inhibitor / ARB CCB BB other: renin inhibitor, ALD receptor antagonist, a1 adrenergic blocker, a2 agonist, peripherial adrenergic blockers, non-specific adrenergic blockers, vasodilators |
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Term
what is the general order for tx of CHF 10 |
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Definition
ACEI/ARB BB: metaprolol, bisprolol Non-specific BB: carvedilol amlodipiine hydralazine inotropic: B agonist, phosphodiesterase inhibitor, nesiritide, digitalis |
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Term
explain the theatment of eldelry of AA with HTN 2 |
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Definition
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Term
explain the TX of HTN post MI 2 |
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Definition
24h: ACEI maintain: ARB, BB |
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Term
explain the TX of HTN in pt with renal failure 1 |
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Definition
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Term
explain TX of HTN in pt with DM 1 |
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Definition
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Term
explain TX of HTN in pregnant pt |
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Definition
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Term
explain TX of HTN in pt with renal HTN |
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Definition
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Term
what is #1 and #2 choice for acute HTN |
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Definition
1. sodium nutroprusside 2. non-specific adrenergic blockers (labelalol, carvedilol) |
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Term
explain TX of HTN in pt with asthma or peripherial vascular disease |
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Definition
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Term
what HTN drugs can tx diabetic nephropathy 2 |
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Definition
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Term
ther than HTN what can BB treat 4 |
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Definition
hyperthyroid migraine prophylaxia glaucoma cardiomyopathy |
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Term
other than HTN what can a1 adrenergic blocker tx |
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Definition
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Term
what than HTN what vasodilator has another use, what is it |
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Definition
minoxidil: topical male pattern baldness |
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Term
what drug do you use in CHF renal failure pt (#1 and #2) |
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Definition
DOC: ACEI/ARB 2: hydralazine |
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Term
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Definition
chlorthalidone hydrochlorothiazide |
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Term
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Definition
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Term
2 ARN (ANGII receptor blocker) |
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Definition
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Term
3 CCB, which can be used for CHF |
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Definition
verapamil diatiazem amlodipine - CHF and HTN |
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Term
explain naming of BB, which can be used in CHF |
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Definition
A-M B1 selective -olol N-Z B1/2 non-selective -olol metapropolol bispropolol |
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Term
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Definition
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Term
2 ALD receptor antagonist |
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Definition
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Term
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Definition
prazosin terazosin doxazosin |
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Term
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Definition
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Term
1 peripherial adrenergic blocker |
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Definition
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Term
2 non-specific adrenergic blockers, which is used in CHF |
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Definition
labetalol carvedilol - CHF and HTN |
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Term
4 vasodilators, which can be used for CHF |
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Definition
hydralazine - CHF and HTN minoxidil Na nitroprusside isorbide dinitrate |
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Term
4 categories of inotropic drugs |
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Definition
B adrenergic antagonist phosphodiesterase inhibitor nesiritide digitalis |
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Term
1 B adrenergic antagonist |
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Definition
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Term
2 phosphodiesterase inhibitor |
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Definition
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Term
what is nesiritide made of |
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Definition
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Term
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Definition
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Term
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Definition
stops electrolyte transport causing Na/water excretion
decreases BV, CO and BO increases urine output
urineoutput, CO, and BV return to normal in days but BP stays fixed due to vascular reactivity to NE and secreased structural resistance
overall: DECREASES PRELOAD |
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Term
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Definition
stops conversion of ANGI to ANGII and bradyinin to inactive
causes vasodilation: inc preload and afterload water/NA excretion: dec preload prevents ALD cardiac remodel
stops renin feedback and renin builds up |
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Term
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Definition
stops ATI receptors so ANGII can't activate ALD or vasoconstrict
vasodilation: dec preload and afterload water/Na excretion: dec preload stops cardiac remodeling |
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Term
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Definition
block L Ca channels in HEART MUSCLE slowing phase 4/0 at AV
decreases CO, increases PR, negative inotropic |
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Term
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Definition
blocks L Ca channel in VESSELS AND HEART causing vasodilation and dec CO |
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Term
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Definition
block L Ca channels in VESSELS causing vasodilation most likley to cause reflex tachycardia |
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Term
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Definition
antagonize B1 on heart dec CO antagonize B1 on JG decreasing renin
vasodilation Na/water excretion stops cardiac remodeling - some...
improves symptoms, exercise tolerance |
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Term
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Definition
low dose, build over 4-5 wks |
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Term
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Definition
stops conversion of angiotensinogen to ANG I
vasodilation Na/water excretion stoms cardiac remodeling - some... increased renin due to loss of neg feedback |
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Term
MOA ALD receptor antagonist |
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Definition
K sparing diruetics (not awesome diruetics) block ALD which causes K wasting
cause Na/water excretion decreasing preload |
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Term
MOA a1 adrenergic blockers |
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Definition
block a1 on ARTERIOLES AND VEINS causing vasodilation |
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Term
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Definition
decrease sympathetic outflow from brainstem vasopressors (main regulator of Na retention) |
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Term
MOA peripherial adrenergic blockers |
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Definition
blocks reuptake of NE/E causig depletion and decreased SNS
vasodilation, dec CO |
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Term
MOA non-specific adrenergic blockers |
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Definition
block A1, B1, B2 decrease TPR without reflex tachycardia |
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Term
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Definition
NO causes ARTERIOLE dilation (increases flow most) |
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Term
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Definition
opens K channels hypopolarizing, dilates ARTERIOLES |
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Term
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Definition
NO dilates VEINS AND ARTERIES |
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Term
administration Na nitroprusside |
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Definition
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Term
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Definition
VENOdilator, decreases proload |
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Term
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Definition
B adrenergic antagonist: dobutamine, dopanine pisphodiesterase inhibitor: inamirone, milrone |
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Term
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Definition
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Term
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Definition
antagonize B1 and increase CO |
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Term
administration dobutamine |
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Definition
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Term
administration of dopamine and effect |
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Definition
<2ug/kg: D1 vasodilate renal 2-5ug/kg: V1 inc CO 5015ug/kg: A1 vasoconstrict, inc TPR |
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Term
MOA phosphodiesterase inhibitor |
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Definition
increase cAMP, phosphorlyates Ca channel increases CO |
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Term
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Definition
vasodilate veins and arteries |
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Term
MOA digtaliz and digitoxin |
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Definition
reversibly bind Na/K ATPase chances Ca/Na channel Ca comes in increases CO decreases SNS, TPR |
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Term
what is the difference between digitalis and digitoxin |
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Definition
digitoxin: t1/2: 15d digitalis: t1/2: 48h
toxin is more toxic |
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Term
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Definition
K depletion (restrict Na intake) increased glucose (don't DC if become diabetic) |
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Term
interactions thiazide diruetics, why |
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Definition
digitallis: messes with Na/K ATPase |
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Term
contraindications thiazide diruetics 3, why |
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Definition
DM: increases glucose chronic arrhythmia, acute MI: messes with K |
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Term
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Definition
catopril cough: due to brady build up angioedema: face and mouth teratogenic acute renal failure |
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Term
why does ACEI cause acute renal failure |
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Definition
ANG II constricts efferent arteriole when renal perfusion is low (never use in bilateral renal artery stenosis) |
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Term
interactions/contraindications ACEI 2 |
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Definition
never use with ARB dont use in renal artery tenosis |
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Term
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Definition
teratogenic acute renal failure |
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Term
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Definition
constipation dizzy naturitic |
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Term
interactions/contrindications of verpamil 3 |
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Definition
no diruetic: its a naturitic no CHF no BB |
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Term
interactions/contrindications of dialtiazem 3 |
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Definition
no diruetic: its a naturitic no CHF no BB |
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Term
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Definition
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Term
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Definition
gingival hyperplasia dizzy reflex tachycardia |
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Term
contraindications amlodipine |
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Definition
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Term
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Definition
inc LDL and TG withdrawl: rebount HTN hypotension bradycardia decreased lobido, lethargy
B2: bronchoconstriction, increases glucose |
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Term
contraindications to BB 2 |
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Definition
dont use non-selective in asthmatic or diabetic |
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Term
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Definition
slight cough angioedema teratopenic |
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Term
SE ALD receptor antagonist |
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Definition
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Term
contraindications to ALD receptor antagonist 2 |
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Definition
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Term
how can you prevent hyperkalemia in ALD receptor antagonist |
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Definition
use in combo with ACRI/ARB |
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Term
SE a1 adrenergic blocker 2 |
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Definition
postural HTN on 1st dose dizzy |
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Term
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Definition
sedation dry mouth withdrawl: rebound HTN hemolytic anemia - methyldopa |
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Term
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Definition
sedation bradycardia depression |
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Term
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Definition
bronchoconstriction arrhythmia (C blockade) dec lobido |
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Term
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Definition
lupus like in slow acetylators reflex tachycardia |
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Term
SE Na nitroprusside, why 2 |
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Definition
hypotension metabolized to cyanide |
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Term
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Definition
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Term
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Definition
anorexia, nausea, vomiting, headache, fatigue, confusion, blurred yellow vision |
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Term
digitalis toxicity signs 8, why |
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Definition
Ca overload increases automaticity causing DAD leading to ... increased systole tachycardia PVC fibrillation complete block VTac VFib |
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Term
things that cause predisposition to digitalis toxicity 4 |
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Definition
hypoklemia: arrhythmia wuinidine and verapamil: displace it diuretics: increase its binding |
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