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FDA DOES NOT REQUIRE PROOF OF EFFICACY, SAFETY, OR QUALITY CONTROL FDA HAS TO PRROVE ITS UNSAFE RATHER THAN PROVE ITS SAFE
can claim to benifits but not cure
NCCAM oversees herbs not really FDA |
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how patients think about herbs |
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dont think doctors are for them dont admit to talking them dont realize 30% of drugs come from herbs |
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possible harms of herbs and why |
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if it has enough power to cause benifit it can cause harm
variability between manufactures, batches, plants, potency
additives may be added and not listed
wrong part of plant could be picked (belladona poisoning, digitalis poisoning)
can have heavy metals |
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why herbs dont have much research |
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controlled studies not profitable studies not required toxic effects seldom reported |
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possible additives found in herbs that are dangerous |
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pesticides non declaired drugs added chemicals heavy metals: Pb, Ar, Cadmium, Cu, Me prednisone testosterone diazepam |
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garlic: MOA, uses 5, SE 1 |
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Definition
allin > allicin (sulfur) > inhibits HMG-CoA reductase and TXA2
tx: hyperlipidemia, HTN, decreases LDL, TG, plaque
SE: ANTICOAGULANT, WATCH OUT WITH WARFARIN |
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in flavonoids, sequiterpenes, terpenes IMPROVE COGNITIVE FUNCTION |
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activates NK cells and monocytes
INCREASE EFFECTS OF IMMUNE SYSTEM
HEPATOTOXICITY IF USED >8WKS |
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in protein, isoflavones, fiber, omega-6-FA
TX HYPERLIPIDEMIA (DECREASES TG, LDL, CHOLESTEROL) |
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5-A-REDUCTASE INHIBITOR TX SYMPTOMS OF BPH |
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sapones called ginsenoides TX FATIGUE |
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st. johns wart: MOA, use, SE |
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increases srtotonin TX DEPRESSION induces P450 |
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valernic acid IMPROVES SLEEP QUALITY |
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glucosamine and chondroitin: sources, use, 3 benifits |
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Definition
glucosamine is AA sugar chondroitin is glycosaminoglycan
TX OSTEOARTHRITIS
DECREASES JOINT PAIN INCREASES MOBILITY INCREASES QUALITY OF LIFE |
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creatinie: sources 2, use, 2 benifits |
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Definition
made from flycine and arginine in urea cycle in meat and fish
EXERCISE PERFORMANCE
INCREASES MUSCLE MASS STRENGTH IN SHORT PERFORMANCE |
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gynecologic disorders: post menopause, menstural discomfort |
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allergies, asthma, impotence |
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heart diseae heart failure |
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gynecological disorders: irregular mensturation, PMS |
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immune stimulant antifertility |
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vericose veins hemorrhoids |
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jet lag sleep induction cancer |
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aphrodisiac male impotence |
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medicines derived from plants |
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Definition
atropine digoxin cholchine reserpine quinine vincristine taxol phygostigmine ephedrine cocaine cslicylin scopolamide pnehylbutazone: NSAID, DC heavy metals aminopyrine: NSAID, DC marrow toxicity |
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