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pharm - HA
Pharm t5
50
Pharmacology
Graduate
04/05/2010

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Cards

Term
3 types of HA:
Definition
1. migranes
2. cluster
3. tension
Term
define: status migranosus:
Definition
migraine lasting longer than 72 hrs w N/V
Term
4 non-pharmacologic tx for migranes:
Definition
1. sleep hygiene
2. hydration
3. regular exercise
4. cognitive techniques
Term
migrane triggers:
Definition
1. food: choc, etoh, aged cheese, MSG
2. environment: weather changes, strong smells, bright lights
3. behaviors: too much/too little sleep, menstruation, stress
Term
3 abortive therapies for migrane HA:
Definition
1. Analgesics (simple and opiod)
2. triptans
3. ergot derivitives
Term
8 simple analgesics:
Definition
1. ibuprofen
2. naproxen
3. diclofenac
4. ASA
5. midrin
6. fiorinal
7. fioricet
8. excedrin (midrin+ASA+caffeine)
Term
3 opiods for migraine:
Definition
1. hydrocodone
2. morphine
3. oxycodone
Term
opiods are reserved for:
Definition
refractory pain
Term
triptan MOA:
Definition
serotonin receptor agonists; increase vasoconstriction and decrease inflamation
Term
when should pts take triptans for migraines:
Definition
early (start of aura)
Term
5 contraindications to triptans:
Definition
1. ischemic heart dz
2. uncontrolled HTN
3. cerebrovacular syndromes
4. ergot alkaloid wn 24h
5. MAOI wn 2wks
Term
triptan: gold standard injection has the fstest onset of all triptans
Definition
Sumatriptan
Term
triptan: at high doses, more effective than sumatriptan:
Definition
Rizatriptan & Eletriptan
Term
triptan: cut dose in half for renal hepatic impairment
Definition
almotriptan
Term
triptan: estrogen and propanolol increase effects:
Definition
Frovatriptan
Term
list 7 triptans:
Definition
1. Suma
2. Zolmi
3. Nara
4. Riza
5. Almo
6. Frova
7. Ele
Term
ergot derivatives MOA:
Definition
serotonin receptor agonist: increases vasoconstriction
Term
4 adverse effects of ergot derivitives:
Definition
1. N/V
2. peripheral numbness/tingling/myalgia
3. itching
4. tachycardia/HTN
Term
5 contraindications to ergot derivitives:
Definition
1. PVD
2. CAD
3. HTN
4. hepatic/renal impairment
5. prego
Term
ergot derivitives BLACK BOX WARNING:
Definition
CYP3A4 inhibitor: azoles, protease inhibitors, macrolides
Term
3 classes of ergotamine derivitives:
Definition
1. dihydroergotamines: DHE45,Migranal
2. Erogotamine: Ergomar
3. Ergotamine+Caffiene: Cafergot & Migergot
Term
4 tx options for migraine prophylaxis:
Definition
1. B-Blockers
2. Anticonvulsants
3. Antidepressants
4. CCBs
Term
first line prophylaxis med for migraines:
Definition
B-blockers
Term
2 anticonvulsants for migraine prophylaxis:
Definition
1. depakote
2. Topamax
Term
alternative first line therapy for migraine prophylaxis:
Definition
TCAs
Term
which TCA for migraine prophylaxis:
Definition
amitriptyline
Term
which TCA for migraine prophylaxis:
Definition
amitriptyline
Term
2nd or 3rd line migrains prophylaxis:
Definition
CCBs: verapamil
Term
4 adverse effects of verapamil (CCB)
Definition
1. hypoTN
2. constipation
3. AV block
4. CHF exacerbation
Term
pain is unilateral, pulsating, can present w or wo aura:
Definition
migraine
Term
list 3 abortive tx and 3 preventive tx for migraines:
Definition
abortive: triptans,ergot,analgesics
preventive: BB,TCAs,Anticonvulsants
Term
most severe type of primary HA:
Definition
cluster HA
Term
most severe type of primary HA:
Definition
cluster
Term
5 triggers for cluster HA:
Definition
1. stress
2. seasonal changes
3. missing meals
4. smoking
5. alcohol
Term
cluster HA may present w one or more of the following:
Definition
1. lacrimation
2. nasal congestion/rhinorrhea
3. eyelid edema
Term
unilateral ice pick through the eye lasting from 45-90min:
Definition
cluster HA
Term
3 abortive tx for cluster Ha:
Definition
1. 10L O2
2. Triptans
3. dyhydroergotamine
Term
3 preventative tx for cluster HAs:
Definition
1. verapamil
2. corticosteroids
3. ergotamine
Term
most common form of primary HA:
Definition
tension
Term
3 subtypes of tension HA:
Definition
1. chronic >15d/month
2. Frequent 1-14d/mo
3. infrequent: <1d/mo
Term
HA lasts 30minutes to 7days:
Definition
tension
Term
tension HAs have at lest 2 of the following 3 assoc sx:
Definition
1. bilateral location
2. pressing/tightening
3. mild/moderate intensity
Term
4 tension HA triggers:
Definition
1. eye strain
2. posture
3. stress
4. hunger
Term
4 non-pharmacologic tx for tension HA
Definition
1. relaxatoin 2. massage 3.
Term
2 abortive tx for tension Ha
Definition
1. acetominophen
2. NSAIDs
Term
2 preventive tx for tension HA:
Definition
1. Bblockers
2. TCAs
Term
bilateral, dull, headband area:
Definition
tension HA
Term
5 causes of secondary HA:
Definition
1. infection
2. Tumor
3. Head injury
4. environmental changes
5. Rebound HAs
Term
5 meds casue rebound HA:
Definition
1. analgesics
2. alcohol
3. ceffiene
4. estrogens
Term
define medication overuse for HAs:
Definition
>15d/month or reg use of >1drug for >3mo to tx acute HA
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