Shared Flashcard Set

Details

Pharm Exam 2
Set 10: Stimulants & Anti-migrane Drugs
22
Pharmacology
Graduate
10/25/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
What is the main clinical use of stimulants (amohetamines)?
Definition
ADHD Tx
Term
What Sx of ADHD do stimulants treat?
Definition
core Sx: impulsivity, inattention, & motor restlessness
Term
def

ADHD
Definition
6+ Sx (from A or B) present for 6+ months to a point that is disruptive & inappropriate for developmental level

A) List of inattention Sx
B) List of Hyperactive/inpulsive Sx
Term
How effective are stimulants are Tx of ADHD?
Definition
so much so that combined CBT is not needed
Term
What are the 5 amphetamines?
Definition
1) Amphetamine
2) DA
3) Methamphetamine
4) Methylphenidate
5) Dextroamphetamine
Term
MOA

amphetamines
Definition
release monoamines thru non-exocytotic mechanism
Term
What form of stimulants have been developed for stable effect throughout the day?
Definition
controlled release
Term
SOA

stimulants
Definition
1) ADHD
2) excessive daytime sleepiness (narcolepsy, sleep apnea, etc)
3) appetite suppressants (historically)
Term
def

migranes
Definition
headaches that are:
1) unilateral
2) pulsatile/throbbing
3) associated with N/V
4) sufficient intensity to interrupt daily activities
5) last 4-72 hrs if untreated
Term
Who is affected by migranes?
Definition
3x more women than men
Term
What tends to be the triggers for mirgranes?
Definition
dietary
Term
MOA

migranes
Definition
neurogenic inflammation
Term
Tx

migranes
(not severe, no vomiting)
Definition
NSAIDs
Term
Tx

severe migranes
Definition
1) Triptans
2) Dihydroergotamine
Term
MOA

triptans
Definition
5-HT1B/1D receptor agonists => inhibition of neurotransmitter release
Term
When in combination with what do triptans seen to be most effective in treating migranes?
Definition
NSAIDs (may be given in combination with antiemetics as well)
Term
CI

triptans
Definition
coronary disease
Term
When in the migrane course should triptans be administered?
Definition
as early as possible (early intervention is important)
Term
Why shouldn't triptans be given as monotherapy?
Definition
Alone, not much better than NSAIDs & have a high cost
Term
What are the 2 triptans?
Definition
1) sumatriptan
2) fovatriptan
Term
Tx

migrane prophylaxis
Definition
1) β blockers (propanolol, timolol, metoprolol)
2) AED (valproate, topiramate)
3) TCAs
4) Behavioral therapies
Term
MOA

future migrane Tx
Definition
CGRP antagonist
Supporting users have an ad free experience!