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Pharm Exam #2 - Anti-Parkinson Agents
Anti-Parkinson Agents
10
Pharmacology
Graduate
11/01/2010

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Cards

Term
L-DOPA/Carbidopa (Sinemet)
Definition
Dopamine precursor
w/decarboxylase inhibitor

SE: GI/vomiting, orthostatic hypotension, dyskinesias, response fluctuations, psychosis (extra dopamine in mesolimbic system, overstim of dopamine receptors)
Term
Bromocriptine (Parlodel)
Definition
DOPAMINE AGONISTS

similar to L-DOPA but psychosis little more common, more likely to cause "sleep attacks"
Term
Pramipexole (Mirapex)
Definition
DOPAMINE AGONISTS

similar to L-DOPA but psychosis little more common, more likely to cause "sleep attacks"
Term
Ropinirole (Requip)
Definition
DOPAMINE AGONISTS

similar to L-DOPA but psychosis little more common, more likely to cause "sleep attacks"
Term
Selegiline (Eldepryl)
Definition
MAO-B INHIBITION

adjunct, no tyramine interaction
Term
Benztropine (Cogentin)
Definition
ANTIMUSCARINICS

atropine like SE's, decrease tremor but little effect on bradykinesia
Term
Trihexyphenidyl (Artane)
Definition
ANTIMUSCARINICS

atropine like SE's, decrease tremor but little effect on bradykinesia
Term
Entacapone (Comtan)
Definition
COMT inhibitors
adjunct
Term
Tolcapone (Tasmar)
Definition
COMT inhibitors
adjunct
Term
Amantadine
Definition
Antiviral
Thought to release dopamine, but may also block muscarinic and/or glutamate receptors
Used early in disease or late to control dyskinesias
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