Term
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Definition
located on postsynaptic effector cells
Any drug that looks like NE and cause VC and increase in BP |
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Term
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Definition
Agonist NE
Antagonist Phentolamine |
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Term
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Definition
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Term
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Definition
located on presynaptic nerve terminals
and control the release of neurotransmitters |
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Term
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Definition
Agonist: NE
Antagonist: none |
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Term
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Definition
| have feedback mechanism and therefore decrese release of NE or dec BP |
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Term
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Definition
are vasocontriction and CNS stimulation
Primarily located on smooth muscle, vasculature or blood vessels |
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Term
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Definition
located primarily in the heart
stimulation cause increase HR |
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Term
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Definition
located in smooth muscle of the bronchioles, arterioles, and visceral organs
Stimulation relax smooth muscle and cause bronchiodilation or vasodilaiton |
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Term
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Definition
resultsi in: bronchial, GI, and uterine smooth muscle relaxation
GLycogenolysis
Cardiac stimulation |
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Term
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Definition
stimulated by Dopamine to inc HR
and causes dilation of the following blood vessels resulting in increase blood flow:
Renal
Mesenteric
Coronary
Cerebrel |
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Term
| alpha 1 receptor locations |
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Definition
Sphincters: constriction (no food allowing
Blood vessels: constriction inc HR
Bladder sphincter: constri no digestion
Penis: ejaculation make cums
Ureus: constriction no pee just cum |
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Term
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Definition
Uterus: relaxation before labor to open the uterus
GI muscle: decrease motility no digestion
Blood vessels: dilation
Lung: inc dilation and relaxaiton to breath better |
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Term
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Definition
| Heart: increase HR and contractility |
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Term
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Definition
is the parent coumpound with sympahtomimetic drugs
Substitutions are at terminal amino group, by OH at 3,4 of benzene, alpha or beta carbons yield Catecholamines |
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Term
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Definition
| is modified to change affinity and selectivity of drugs for alpha and beta receptors |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
Tyrosine--(tyrosine hydrosylase)---
DOPA---(dopa decarboxylase)---
Dopamine---(dopamine-beta-hydroxylase)----
NE---(Phenylethanolamine-methyl transferase--)
EPinephrine |
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Term
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Definition
| through MAO and COMT to make MHPG and VMA to secrete through urine |
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Term
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Definition
Direct acting sympathomimetic:
binds directly to the receptor and causes a physiologic response
Indirect-acting sympathomimetic:
causes the release ot catecholamine from the storage sites in the nerve endings |
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Term
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Definition
| "Tyramine-like" effect: drug interaction of MAOI with tyramine foods (beer, fava beans, cheese, yeast red wine...) will result in hypertensive crisis |
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Term
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Definition
Normal by-product of tyrosine metabolism
Fermented foods cheese
Inactive oral because of high first pass effect, low bioavilability
IV |
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Term
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Definition
IV has indirect sympathomimetic action result of release of stored catecholamine
Drug interaction with MOAI, effect of tyramine is intensified, hypertensive crisis
Patient on MAOI must avoid tyramine containing foods |
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Term
| TYRAMINE containing foods |
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Definition
Broad beans, fava beans
Cheese, natural or aged, cheddar gruyere
Chicker liver
Chocolate
Sausage
Smoked herring
Snails
Wine
Yeast |
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Term
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Definition
| Anorexiants: adjuncts to diet in the short-term management of obesity |
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Term
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Definition
| Anorexiants: adjuncts to diet in the short-term management of obesity |
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Term
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Definition
| Anorexiants: adjuncts to diet in the short-term management of obesity |
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Term
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Definition
| Anorexiants: adjuncts to diet in the short-term management of obesity |
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Term
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Definition
| Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation |
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Term
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Definition
| Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation |
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Term
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Definition
| Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation |
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Term
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Definition
| Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation |
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Term
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Definition
| Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation |
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Term
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Definition
| Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation |
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Term
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Definition
| Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation |
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Term
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Definition
| Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation |
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Term
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Definition
| Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation |
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Term
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Definition
Non-selective B1,B2 agonist
Most potent
Indication: bronchiodilator
Inhaler rapid onset
SE: cardiac arrhythmia |
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Term
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Definition
Non-selective B1, B2
Inhaler
For Bronchiodilator |
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Term
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Definition
Prototype oral
B2 selective
PO (peorum mean by mouth),
subcutaneous, inhaler, and Iv
PO long duration
Will cause cardiac arrhythmia only at higher doses
SE:
skeletal muscle tremor
restlessness |
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Term
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Definition
B2 agonist
Relaxes uterine smooth muscle
Indication: premature labor
may also used terbutaline |
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