Term
| Alzheimer’s Disease: underlying cause unknown |
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Definition
Progression: Mild, Moderate, Severe:
Progressive Memory Loss
Impaired Thinking
Neuropsychiatric symptoms (hallucinations, delusions)
Inability to perform routine tasks of daily living |
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Term
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Definition
| Memory loss and confusion and disorientation at times. Also impaired judgment, personality changes. |
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Term
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Definition
| increasing difficulty with activities of daily living, increases of items from early stage, increased behavior problems/issues (wandering/pacing/agitation/screaming) (sundowning: symptoms worsen of an evening and at night). |
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Term
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Definition
| (Final stages) unable to recognize family, loss of communication, identity is lost, completely dependent. |
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Term
1 time till death with AD?
2 % and age of common pts with AD |
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Definition
1: can be up to 20 yr but usually 6-8
2 90% over are 65 or older |
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Term
Major pathologic findings of AD |
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Definition
| are degeneration of cholinergic neurons and the presence of neuritic plaques and neurofibrillary tangles. |
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Term
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Definition
| levels of acetylcholine (ACh) are 90% below normal. ACh is important transmitter in the hippocampus and cerebral cortex, regions where neuronal degeneration occurs. ACh is critical to forming memories, and its decline has been linked to memory loss. |
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Term
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Definition
| early detection and early tx |
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Term
| therapy for AD focuses on ? |
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Definition
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Term
| 1st class of drugs approved for use with AD. |
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Definition
Cholinesterase Inhibitors:
(Donepezil: Aricept) Know med….
(this will be on a different flashcard) |
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Term
Cholinesterase Inhibitors
(AD) |
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Definition
| Prolonged plasma half-life (about 60 hours) and given once dailyReduced dose, labs monitored. (Not specifically hepatotoxic) **Somewhat selective for brain cholinesterase but it can cause peripheral cholinergic effects: nausea, diarrhea mostly but also bradycardia especially in pts that already have heart disease. |
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Term
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Definition
(same class as Aricept)
These meds treat symptoms (issues with memory) but not treating underlying disease. Half-life 60-80 hours… Know Mechanism of Action of these meds and side effects….main listed above but with this one also: dizziness, headache, confusion. |
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Term
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Definition
| Antioxidant properties. Help protect from neuronal injury. |
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Term
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Definition
| Nonsteroidal Anti-Inflammatory drugs in long-term use |
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