Highly selective blockade of serotonin transporter (SERT), little effect on norepinephrine transporter (NET)

Acute increase of serotonergic synaptic activity, slower changes in several signaling pathways and neurotrophic activity

Well tolerated but cause sexual dysfunction (30-40%)

Depression in children

Loss of libido

GI effects, insomnia, weight gain

Major depression, anxiety disorders, panic disorder, obsessive compulsive disorder, post-traumatic stress disorder, perimenopausal vasomotor symptoms, eating disorder (bulimia)

Highly selective blockade of serotonin transporter (SERT), little effect on norepinephrine transporter (NET)

Acute increase of serotonergic synaptic activity, slower changes in several signaling pathways and neurotrophic activity

Well tolerated but cause sexual dysfunction (30-40%)

Depression in children

Loss of libido

GI effects, insomnia, weight gain

Major depression, anxiety disorders, panic disorder, obsessive compulsive disorder, post-traumatic stress disorder, perimenopausal vasomotor symptoms, eating disorder (bulimia)

Highly selective blockade of serotonin transporter (SERT), little effect on norepinephrine transporter (NET)

Acute increase of serotonergic synaptic activity, slower changes in several signaling pathways and neurotrophic activity

Well tolerated but cause sexual dysfunction (30-40%)

Depression in children

Loss of libido

GI effects, insomnia, weight gain

Major depression, anxiety disorders, panic disorder, obsessive compulsive disorder, post-traumatic stress disorder, perimenopausal vasomotor symptoms, eating disorder (bulimia)

Highly selective blockade of serotonin transporter (SERT), little effect on norepinephrine transporter (NET)

Acute increase of serotonergic synaptic activity, slower changes in several signaling pathways and neurotrophic activity

Well tolerated but cause sexual dysfunction (30-40%)

Depression in children

Loss of libido

GI effects, insomnia, weight gain

Major depression, anxiety disorders, panic disorder, obsessive compulsive disorder, post-traumatic stress disorder, perimenopausal vasomotor symptoms, eating disorder (bulimia)

Moderately selective blockade of NET and SERT

Acute increase in serotonergic and adrenergic synaptic activity (otherwise like SSRIs)

Many of serotonergic adverse effects associated with SSRIs

Depression in children

Loss of libido

Noradrenergic effects: ↑BP, ↑HR,

CNS effects: insomnia, anxiety

Major depression, chronic pain disorders, fibromyalgia, perimenopausal symptoms

Moderately selective blockade of NET and SERT

Acute increase in serotonergic and adrenergic synaptic activity (otherwise like SSRIs)

Many of serotonergic adverse effects associated with SSRIs

Depression in children

Loss of libido

Noradrenergic effects: ↑BP, ↑HR,

CNS effects: insomnia, anxiety

Major depression, chronic pain disorders, fibromyalgia, perimenopausal symptoms

Mixed and variable blockade of NET and SERT

Lite SNRIs plus significant blockade of autonomic nervous system and histamine receptors

Anticholinergic effects: dry mouth, constipation, urinary retention, blurred bison, confusion

α-blocking effects: orthostatic hypotension

H₁ antagonism: weight gain, sedation

arrhythmias

Major depression not response to other drugs, chronic pain disorders, incontinence, obsessive compulsive disorder

Inhibition of 5-HT_2A receptor

Forms a metabolite (m-cpp) that blocks 5-HT_2A,2C receptors

H₁ receptor blockade: sedation,

α receptor blockade: orthostatic hypotension

GI effects

Major depression, used for sedation and hypnosis

insomnia

Irreversible, nonselective blockade of MAO-A and MAO-B

Anticholinergic effects

Orthostatic hypotension and weight gain are most common

highest rates of sexual effects of all antidepressants

restlessness, insomnia

Major depression unresponsive to other drugs