Term
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Definition
venodilator decreases preload which decreases work on heart |
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Term
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Definition
angina SL for acute attack not great preventitive |
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Term
drugs good vo vasospasm angina |
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Definition
never BB CCB vascular specific - amlodipine |
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Term
drugs good for stable angina prevention |
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Definition
#1 is BB any CCB will work (amlodipine, ditilzaim, verapmil) |
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Term
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Definition
work on ascending loop of henle targeting Na/K/2Cl diuretic |
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Term
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Definition
loops loose Ca ototoxic K loss and thus H loss so metabolic acidosis |
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Term
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Definition
DOC acute pulmonary edema |
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Term
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Definition
works on DCT NaCl channels |
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Term
hydrochlorothiazide: SE 4 |
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Definition
K loss and thus H loss so metabolic acidosis thiazides save Ca hyperglycemia |
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Term
hydrochlorothiazide: use 2 |
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Definition
DOC daily fluid balance duiretic (long half life) DI NOT caused by lithium |
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Term
what is used to tx DI caused by lithium, why |
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Definition
amularide: becaue lithium and Na are similar in size and charge. comes into CD through Na channels |
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Term
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Definition
works in CD as direct Na channel blocker K sparing |
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Term
eplerone and spironolactone: MOA |
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Definition
works in CD as ALD receptor blocker decreasing number of Na chennals, thus indirect CD blocker K sparing |
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Term
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Definition
if you save K you save H causing metabolic acidosis |
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Term
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Definition
lowers VLDL, TG raises HDL |
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Term
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Definition
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Term
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Definition
bile acid sequesterant (ie cholesterol) complexes with bile so you cannot recycle them and you loose them from the body and liver needs to make more bile acids and thus need to pull cholesterol from the blood to do it |
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Term
cholestyramine: contrindications, why |
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Definition
hyperTG patients: further increases TG because when liver starts making more bile acids it starts making other lipids too |
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Term
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Definition
HMG CoA reductase (rate limiting step in cholesterol synthesis) inhibitor benifit all aspects of lipid profile |
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Term
which statin is most likley to raise HDL, which is least |
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Definition
atrivostatin > simvastatin |
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Term
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Definition
muscle toxicity (myalgia, myositis, rhabdomyalgia) |
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Term
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Definition
take with P450 inhibitor increases statin levels and risk of muscle toxicity (never drink grapefruit juice!) |
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Term
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Definition
increases gene expression of PPARy which increases lipoprotein lipase which lowers TG |
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Term
what two NT and change in parkinsons disease |
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Definition
decreased dopamine increased ACh (Relative) |
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Term
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Definition
taken into CNS and turned into dopamine use carbadopa to avoid DOPA decarboxylase break down in periphery |
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Term
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Definition
dopamine agonist directly stimulates D2 receptors |
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Term
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Definition
stops metabolism of dopamine by MAOB blocking it |
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Term
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Definition
in periphery and CNS levodopa is converted to 3-o-methyodopa by COMT drug blocks COMT to increases levadopa conversion to dopamine |
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Term
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Definition
targets ACh, muscarinic blocker lowers effect of ACh in parkinsons |
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Term
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Definition
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Term
drugs used for parkinsons |
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Definition
levodopa/carbadopa ropinerole selegiline entacapone benzotropine |
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Term
explain the break down process of ethanol and the SE 3 |
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Definition
ethanol > alcohol DH > acetaaldehyde > aldehyde DH > acid aldehyde > acidosis, N/V, headache |
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Term
explain break down process of methanol and the SE 2 |
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Definition
methanol > alcohol DH > formeldahyde > aldehyde DH > formic acid > acidosis, eye damage |
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Term
explain break down process of ethylene glycol and the SE 2 |
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Definition
ethylene glycol > alcohol DH > aldehyde > aldehyde DH > acid aldehyde > acidosis, kidney damage |
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Term
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Definition
blocks aldehyde DH causing aldehyde buildup which causes toxic effects deturing from alcohol use |
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Term
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Definition
methylphenidate dextroamphetamine |
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Term
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Definition
promote release of NE and dopamine |
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Term
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Definition
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Term
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Definition
tachycardia sweating increased BP |
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Term
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Definition
uses antithombin III to cleave IIa, IXa, XIa, XIIa works on activated factors so works rapidly |
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Term
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Definition
protamine: directly complexes with heparin stopping its action rapid onset |
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Term
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Definition
heparin induced thrombocytopenia (stop all drugs working through antithrombin III if induced, not just heparin) |
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Term
how can heparin be monitered |
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Definition
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Term
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Definition
low molecular weight heparin |
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Term
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Definition
takes time, decreased synthesis of II, IV, IX, X by stopping vitamin K |
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Term
warfarin antidote and MOA |
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Definition
Vit K: never going to be fast fresh frozen plasma: fast, replenishes clotting factors |
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Term
how is warfarin monitered |
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Definition
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Term
rivaroxban: MOA, how monitored |
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Definition
blocks factor Xa no need to monitor |
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Term
dabigatran: MOA, how monitored |
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Definition
direct thrombin inhibitor no need to monitor |
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Term
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Definition
ADP receptor blocker cannot activate platelets good back up to aspirin |
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Term
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Definition
glycoprotein IIb/IIIa inhibitor blocks fibrinogen receptors prevents cross linking in platelet aggregation |
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Term
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Definition
angioplasty acute coronary syndromes unstable angina |
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Term
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Definition
tPA fibrinolytic breaks down clots |
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Term
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Definition
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