ACE I

kidney sparing.

ARB AT-1

hyperkalemia

pregnancy

organic nitrate

murmur + angina

organic nitrate

selective for vascular sm

malignant hypertension, acute heart failure

Vit B12 reduce toxicity

arterial relaxant

interferes with K coupled insulin secretion

hyperglycemia

arterial relaxant

with beta blocker for reflex tachy

with diuretic + captopril for reflex renin

headache, flushing, lupus-like. slow acetylator

phosphodiesterase type 5 inhibitor

36 hours

increase K+ efflux result in hyperpolarization, redution of ATP sensitive K channel

baroreceptor kicks in: control with beta blocker + diuretics