inhibit lipolysis in adipose

inhibit TG, CETP synthesis in liver

decrease plasma FFA

decrease VLDL + LDL cholesterol.

ccccutaneous flushing, pruritis, peptic ulcer, jaundice

take aspirin for flushing.

hepatic toxicity and hepatitis like syndrome in slow release formula.

contraindication: peptic ulcer, hepatic disease, DM, gout,

bile resin

prevent bile reabsorption in intestine, lose in feces

increase LDL receptor on liver

pruritis,

not in familial hypercholesterolemia b/c can't increase LDL

patient compliance

increase TG/VLDL b/c relief in phosphatidic acid phosphatase inhibiton.

interact with acidic drugs: digitalis, warfarin, phenobarbital, FAT DEAK.

HMG-CoA reductase blocker

block cholesterol  production

increase LDL receptor on liver and peripheral tissue

decrase sm proliferation and migration

increase osteoblast

anti inflammatory

use with resin + niacin = 60-70% dec. LDL

hepatotoxicity, rhabdomyopathy.

teratogenic effect

HMG-CoA reductase blocker

VLDL synthesis inhibitor

HMG-CoA reductase blocker

LDL-c high

cholesterol uptake inhibitor from gut

glucuronidated by liver and secreted in bile.

additive with statin.

fibrate

PPAR

increase LPL

decrease TG

cholelithiasis, cholecystisi, flu-like symptom, cardiac arrhythmia in CAD, moratality

interacts with warfarin, inhibit platelet aggregation

best fibrate

PPARs

decrease TG synthesis

increase LPL

for HyperTGemia

increase LCAT activity

omega-3 fatty acid

competes w/ arachidonate

inhibit TG synthesis

reduce morbildity from atherosclerosis

non-resin bile acid sequestrant

binds bile acid to prevent reabsorption

Niacin

Fibrate

Marine Oil

resin

statin

ezetimibe

niacin