prototype alpha 1 agonist

decongestant: shrink mucosa + reduce mucus secr.

induce reflex slowing of heart in PAT

induce mydriasis w/o affecting accommodation

selective alpha 2 agonist

diarrhea, opioid withdrawal

tox: dry mouth, sedation, should NOT be abruptly discontinued.

most beta 2 selective agonist

nocturnal asthma

partial agonist

alpha 1, pan beta agonist

increase NE, EPI release

cross BBB

resistant to MAO

asthma, hypotention

prototype selective alpha 1 blocker

BPH, HTN

liver metabolized.

Tox: postural hypotension as first dose effect, inhibit ejaculation,

pan alpha blocker, reversible

pheochromocytoma, male erectile dysfunction

reduction of peripheral resistance

Tox: block serotonin, increase muscarinic + histamine receptor => tachycardia

pan alpha blocker, irreversible

alpha 1 blocker beta blocker

HTN

Tx: little Tach

alpha 2 blocker

depression,

reverse A2 effect

prototype pan beta blocker

essential tremor reduction

poor bioavialability but extensive first pass hepatic meta.

cross BBB

Tox: pt. on hypoglycemic drug, abrupt cessation precipitate angina

pan beta blocker

glaucoma w/o ccausing miosis

pan beta blocker, partial agonist

for HTN w/ significant decrease in cardiac reserve b/c produce smaller reduction in resting HR

prototype beta 1 blocker

decrease CO

decrease rennin

neuronal blocking agent

block Ne neuronal vesicle amine transport mechanism, deplete intracellular NE.

inhibits sympathetics

neuronal blocking

block NE, EPi uptake via uptake 1

stimulate Sympathetics