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Pharm-ANS uterus
pharm
14
Veterinary Medicine
Undergraduate 3
05/25/2012

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Term
ueterus relaxants=
Definition
-aid obstetrical maneouvres during parturition
-facilitate handling of uterus during caesarian section
-delay onset of labour (if labour starts too soon)
Term
ecbolic agenst =
Definition
-hasten labour (if slow or ineffective contractions)
-induce abortion
-limit postpartum bleeding
-eject retained placenta
Term
PSNS innervation of myometrium =
Definition
none!
Term
SNS innervation of myometrium =
Definition
NA releasd =activates alpha 1 R = contraction
Term
circulating adr /beta 2 agonists effect on myometrium =
Definition
activate beta 2 R = decr contractions
Term
oxytocin and PGF2alpha cause...
Definition
...myometrial contraction
Term
expression of alpha 1 and beta 2 Rs =
Definition
varies between sp, and changes during preg
Term
in gravid uterus are there more alpha 1 or more beta 2 Rs?
Definition
alpha 1 > beta 2

(as well as there being more oxytocin and PGF2alpha Rs)
Term
name 2 uterus relaxants
Definition
clenbuterol
vetrabutine
Term
clenbuterols mech =
Definition
beta 2 agonist = decr contraction
Term
what utereus relaxant is banned in livestock/food animal?
Definition
clenbuterol
Term
vetrabutines mech -
Definition
inhibits phosphodiesterase =inhibit breakdown of cAMP =incr cAMP= inhibit myosin light chain kinase (MLC kinase = inhibit phopsphorylation of MLC = relaxation of smooth mm
Term
ecbolic agents =
Definition
1.oxytocin 2.carbotocin (synthetic analogue of oxytocin) 3.extract of mammalian pituitary gland containing oxytocin 4. synthetic analogues of PGF2alpha
Term
synthetic analogues of PGF2alpha =
Definition
cloprostenol
dinoprost
lupristol
tiaprost
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