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-aid obstetrical maneouvres during parturition -facilitate handling of uterus during caesarian section -delay onset of labour (if labour starts too soon) |
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-hasten labour (if slow or ineffective contractions) -induce abortion -limit postpartum bleeding -eject retained placenta |
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PSNS innervation of myometrium = |
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SNS innervation of myometrium = |
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NA releasd =activates alpha 1 R = contraction |
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circulating adr /beta 2 agonists effect on myometrium = |
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activate beta 2 R = decr contractions |
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oxytocin and PGF2alpha cause... |
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Definition
...myometrial contraction |
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expression of alpha 1 and beta 2 Rs = |
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varies between sp, and changes during preg |
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in gravid uterus are there more alpha 1 or more beta 2 Rs? |
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alpha 1 > beta 2
(as well as there being more oxytocin and PGF2alpha Rs) |
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beta 2 agonist = decr contraction |
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what utereus relaxant is banned in livestock/food animal? |
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Definition
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inhibits phosphodiesterase =inhibit breakdown of cAMP =incr cAMP= inhibit myosin light chain kinase (MLC kinase = inhibit phopsphorylation of MLC = relaxation of smooth mm |
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Term
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Definition
1.oxytocin 2.carbotocin (synthetic analogue of oxytocin) 3.extract of mammalian pituitary gland containing oxytocin 4. synthetic analogues of PGF2alpha |
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synthetic analogues of PGF2alpha = |
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Definition
cloprostenol dinoprost lupristol tiaprost |
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