Term
What is acyclovir given for? How does resistance happen? How does it work? |
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Definition
HSV and VSV, activated to acyclovir triphosphate by thymidine kinase in virus, guanosine analogue is incorporated into viral DNA, chain termination, mutation in viral DNA- poly, TK- strains are resistant |
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Term
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Definition
delirium, tremor, seizures, hypotension, nephrotox |
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Term
Famciclovir is converted to... |
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Definition
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Term
What is famciclovir given for? Is it phosphorylated? Does it terminate the chain? |
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Definition
genital HSV and zoster, yes, NO |
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Term
valacyclovir is converted to... |
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Definition
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Term
what is the benefit of valacyclovir? |
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Definition
increased plasma levels, longer DOA |
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Term
Is foscarnet phosphorylated? What does it do? |
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Definition
no, inh viral RNA poly, DNA poly, HIV RTase |
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Term
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Definition
nephrotox, decreased Ca, GU ulcers, CNS effects |
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Term
Does ganciclovir need phosphorylation? What does it do? Does it terminate the chain? |
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Definition
yes, inh DNA poly of HSV, and CMV, and other, NO |
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Term
Is TK- HSV resistant to ganciclovir? |
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Definition
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Term
How are foscarnet and ganciclovir given? What is gancicovir given for? |
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Definition
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Term
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Definition
leukopenia, thrombocytopenia, mucositis, hepatic dysfunction, seizure -- like radiation therapy side effects |
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Term
What phosphorylates cidofovir? What does it do? |
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Definition
HOST kinases, inh DNA poly of HSV, CMV, adeno, papillomaviruses |
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Term
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Definition
IV, topical, intravitreal |
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Term
For most of the anti-herpes drugs, renal elimination is equal to... |
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Definition
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Term
What is cidofovir given for? Tox? |
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Definition
CMV retinitis, HSV, HPV, tox- nephro |
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Term
Which anti-herpes drug can have up to 1/3 deposited in bone? |
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Definition
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Term
Penciclovir is used in which form? |
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Definition
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Term
What is valganciclovir used for? |
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Definition
CMV retinitis and prophylaxis |
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Term
How is trifluridine used? For what? |
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Definition
Topically, for herpes keratitis and acyclovir-resistant HSV |
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Term
What class of drugs are these? - Abacavir, didanosine (ddI), emtricitabine, lamivudine, stavudine, tenofovir, zalcitabine, zidovudine |
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Definition
NRTI - nucleoside reverse transcriptase inhibitors |
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Term
all NRTIs carry the risk of... |
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Definition
lactic acidosis with hepatic steatosis |
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Term
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Definition
BM suppression, anemia, neutropenia, GI, HA, thrombocytopenia, myalgia, cholestatic hepatitis, insomnia |
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Term
What should you do before giving abacavir? |
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Definition
test to rule out HLA B*5701 |
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Term
What impairs the absorption of ddI (didanosin)? What else should you avoid at the same time? |
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Definition
food, fluoroquinolones and tetracyclines |
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Term
didanosine (ddI), zalcitabine and stavudine are ____ drugs that can cause _______ |
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Definition
NRTI, peripheral neuropathy |
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Term
didanosine and zalcitibine are ____ drugs than can cause... |
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Definition
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Term
Which NRTIs can cause pancreatitis? |
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Definition
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Term
Which NRTIs can cause peripheral neuropathy? |
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Definition
ddI, stavudine, zalcitabine |
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Term
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Definition
hypersensitivity, can cause multiorgan failure |
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Term
If you're taking ddI , you should avoid... |
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Definition
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Term
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Definition
mild, GI, HA, insomnia, fatigue |
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Term
What class of drug are these: Delavirdine, efavirenz, etravirine, nevirapine |
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Definition
non-nucleoside reverse transcriptase inhibitors- NNRTIs |
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Term
Are NNRTI drugs phosphorylated? |
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Definition
no, and they bind the RT at a different site |
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Term
Which NNRTI can raise cholestrol, cause CNS dysfunction, and a rash? |
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Definition
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Term
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Definition
major interactions due to CYP metabolism, skin rash |
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Term
Which NNRTI can cause SJ syndrome? |
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Definition
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Term
Which NNRTI can cause occasionally fulminant hepatitis? |
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Definition
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Term
What type of drug is enfuvirtide? |
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Definition
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Term
Drugs that end with "-avir" are generally what types of drugs? What are the exceptions? |
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Definition
protease inhibitors, abacavir, reltegravir, and tenfovir |
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Term
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Definition
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Term
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Definition
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Term
Which protease inhibitor can prolong the PT and/or QT intervals? |
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Definition
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Term
Best to take indinavir with food? |
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Definition
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Term
Protease inhibitors have effects on... |
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Definition
carbohydrate and lipid metabolism |
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Term
Which drug is used in HBV? |
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Definition
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Term
Which drug inhibits GTP formation, capping of viral mRNA and RNA polymerase? |
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Definition
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Term
Which drugs work on influenza A by affecting viral adsorption, penetration and uncoating? Tox? |
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Definition
amantadine and rimantadine, tox - ataxia, dizziness, slurring, GI |
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Term
Which are the neuroaminidase inhibitors? |
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Definition
oseltamavir and zanamavir |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
condensed version: side effects of ganciclovir? |
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Definition
neutro,thrombo and leukocytopenia |
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Term
Anti-viral agents associated with SJ syndrome? |
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Definition
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Term
Which class of HIV drugs have extensive drug interactions due to inhibition of metabolizing enzymes? |
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Definition
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Term
Anti-virals that are teratogens? |
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Definition
Delavirdine, efavirenz, and ribavirin |
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Term
Anti-virals associated with neutropenia? |
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Definition
ganciclovir, zidovudine, saquinavir and IFN |
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Term
Which HIV med is used to reduce transmission to baby during birth? |
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Definition
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Term
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Definition
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Term
Anti-viral with a dose-limiting toxicity of pancreatitis? |
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Definition
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