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Pharm 49 - Antivirals
Antiviral drugs
60
Pharmacology
Professional
10/13/2011

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Cards

Term
What is acyclovir given for? How does resistance happen? How does it work?
Definition
HSV and VSV, activated to acyclovir triphosphate by thymidine kinase in virus, guanosine analogue is incorporated into viral DNA, chain termination, mutation in viral DNA- poly, TK- strains are resistant
Term
Toxicity of acyclovir?
Definition
delirium, tremor, seizures, hypotension, nephrotox
Term
Famciclovir is converted to...
Definition
penciclovir
Term
What is famciclovir given for? Is it phosphorylated? Does it terminate the chain?
Definition
genital HSV and zoster, yes, NO
Term
valacyclovir is converted to...
Definition
acyclovir, by the liver
Term
what is the benefit of valacyclovir?
Definition
increased plasma levels, longer DOA
Term
Is foscarnet phosphorylated? What does it do?
Definition
no, inh viral RNA poly, DNA poly, HIV RTase
Term
Toxicity of foscarnet?
Definition
nephrotox, decreased Ca, GU ulcers, CNS effects
Term
Does ganciclovir need phosphorylation? What does it do? Does it terminate the chain?
Definition
yes, inh DNA poly of HSV, and CMV, and other, NO
Term
Is TK- HSV resistant to ganciclovir?
Definition
yes
Term
How are foscarnet and ganciclovir given? What is gancicovir given for?
Definition
IV, CMV - retinitis
Term
Ganciclovir - tox?
Definition
leukopenia, thrombocytopenia, mucositis, hepatic dysfunction, seizure -- like radiation therapy side effects
Term
What phosphorylates cidofovir? What does it do?
Definition
HOST kinases, inh DNA poly of HSV, CMV, adeno, papillomaviruses
Term
How is cidofovir given?
Definition
IV, topical, intravitreal
Term
For most of the anti-herpes drugs, renal elimination is equal to...
Definition
creatinine clearance
Term
What is cidofovir given for? Tox?
Definition
CMV retinitis, HSV, HPV, tox- nephro
Term
Which anti-herpes drug can have up to 1/3 deposited in bone?
Definition
foscarnet
Term
Penciclovir is used in which form?
Definition
topical
Term
What is valganciclovir used for?
Definition
CMV retinitis and prophylaxis
Term
How is trifluridine used? For what?
Definition
Topically, for herpes keratitis and acyclovir-resistant HSV
Term
What class of drugs are these? - Abacavir, didanosine (ddI), emtricitabine, lamivudine, stavudine, tenofovir, zalcitabine, zidovudine
Definition
NRTI - nucleoside reverse transcriptase inhibitors
Term
all NRTIs carry the risk of...
Definition
lactic acidosis with hepatic steatosis
Term
Toxicity of zidovudine?
Definition
BM suppression, anemia, neutropenia, GI, HA, thrombocytopenia, myalgia, cholestatic hepatitis, insomnia
Term
What should you do before giving abacavir?
Definition
test to rule out HLA B*5701
Term
What impairs the absorption of ddI (didanosin)? What else should you avoid at the same time?
Definition
food, fluoroquinolones and tetracyclines
Term
didanosine (ddI), zalcitabine and stavudine are ____ drugs that can cause _______
Definition
NRTI, peripheral neuropathy
Term
didanosine and zalcitibine are ____ drugs than can cause...
Definition
NRTIs, pancreatitis
Term
Which NRTIs can cause pancreatitis?
Definition
ddI and zalcitibine
Term
Which NRTIs can cause peripheral neuropathy?
Definition
ddI, stavudine, zalcitabine
Term
Tox of abacavir?
Definition
hypersensitivity, can cause multiorgan failure
Term
If you're taking ddI , you should avoid...
Definition
alcohol
Term
Lamivudine - tox?
Definition
mild, GI, HA, insomnia, fatigue
Term
What class of drug are these: Delavirdine, efavirenz, etravirine, nevirapine
Definition
non-nucleoside reverse transcriptase inhibitors- NNRTIs
Term
Are NNRTI drugs phosphorylated?
Definition
no, and they bind the RT at a different site
Term
Which NNRTI can raise cholestrol, cause CNS dysfunction, and a rash?
Definition
efavirenz
Term
Delavirdine- tox?
Definition
major interactions due to CYP metabolism, skin rash
Term
Which NNRTI can cause SJ syndrome?
Definition
nevirapine
Term
Which NNRTI can cause occasionally fulminant hepatitis?
Definition
nevirapine
Term
What type of drug is enfuvirtide?
Definition
fusion inhibitor
Term
Drugs that end with "-avir" are generally what types of drugs? What are the exceptions?
Definition
protease inhibitors, abacavir, reltegravir, and tenfovir
Term
What is miraviroc?
Definition
a CCR5 inhibitor
Term
What is raltegravir?
Definition
integrase inhibitor
Term
Which protease inhibitor can prolong the PT and/or QT intervals?
Definition
atanzavir
Term
Best to take indinavir with food?
Definition
NO
Term
Protease inhibitors have effects on...
Definition
carbohydrate and lipid metabolism
Term
Which drug is used in HBV?
Definition
lamivudine
Term
Which drug inhibits GTP formation, capping of viral mRNA and RNA polymerase?
Definition
ribavirin
Term
Which drugs work on influenza A by affecting viral adsorption, penetration and uncoating? Tox?
Definition
amantadine and rimantadine, tox - ataxia, dizziness, slurring, GI
Term
Which are the neuroaminidase inhibitors?
Definition
oseltamavir and zanamavir
Term
DOC for influenza A?
Definition
amantadine
Term
DOC for RSV?
Definition
ribivirin
Term
DOC for CMV retinitis?
Definition
ganciclovir
Term
condensed version: side effects of ganciclovir?
Definition
neutro,thrombo and leukocytopenia
Term
Anti-viral agents associated with SJ syndrome?
Definition
nevirapine, amprenivir
Term
Which class of HIV drugs have extensive drug interactions due to inhibition of metabolizing enzymes?
Definition
protease inhibitors
Term
Anti-virals that are teratogens?
Definition
Delavirdine, efavirenz, and ribavirin
Term
Anti-virals associated with neutropenia?
Definition
ganciclovir, zidovudine, saquinavir and IFN
Term
Which HIV med is used to reduce transmission to baby during birth?
Definition
AZT
Term
DOC for herpes?
Definition
acyclovir
Term
Anti-viral with a dose-limiting toxicity of pancreatitis?
Definition
didanosine
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