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Pharm 33
Golan Second Edition
51
Pharmacology
Graduate
03/11/2011

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Cards

Term
Fosfomycin, Fosmidomycin
Definition
Gram-negative UTI: E. coli, Klebsiella, Serratia, Clostridia (Headache, GI etc) [Hypersensitivity] Synergistic with beta-lactams, aminoglycosides, fluoroquinolones. Decreased absorption with antacids.
Term
Inhibitors of Murein Monomer Synthesis
Definition
Fosfomycin, Fosmidomycin, Cycloserine, Bactracin
Term
Posphoenolpyruvate (PEP) analogues
Definition
Fosfomycin, Fosmidomycin
Term
Cycloserine
Definition
M. tuberculosis/avium (seizures, somnolence, peripheral neuropathy, psychosis) [Epilepsy, depression anxiety, psychosis, renal insufficiency, alcoholism] Alcohol/isoniazid/ethionamide potentiate toxicity, pyridoxine reduces neuropathy, inhibits hepatic phenytoin metabolism
Term
Alanine racemase and D-Ala-D-Ala senthetase inhibitor
Definition
Cycloserine
Term
Bacitracin
Definition
topical infections, C. difficile or VRE (Avoid systemic absorption for nephro/neuro/myelo toxicity, contact dermatitis) [Nephrotoxic agents or neuromuscular blockade]
Term
Bactoprenol pyrophosphate dephosphorylation inhibitor
Definition
Bacitracin
Term
Inhibitors of Murein Polymer Synthesis
Definition
Vancomycin, Teicoplanin
Term
Vancomycin, Teicoplanin
Definition
MRSA (IV), C. difficile (oral) (Neuropenia, ototoxicity, nephrotoxicity, anaphylaxis, Red-man syndrome, rash/hypersensitivity) [Dextrose can cause corn allergy] Increased aminoglycoside nephrotoxicity, D-Ala-D-lactate resistance, Teicoplanin not available in US
Term
Transglycosidase inhibitor
Definition
Vancomycin, Teicoplanin, Bind to D-Ala-D-Ala terminus
Term
Polymer Cross-linking Inhibitors
Definition
Penicillins
Term
Beta-lactams
Definition
Penicillins
Term
Transpeptidase inhibitors
Definition
Penicillins
Term
Penicillins
Definition
G, V; Oxa/Cloxa/Dicloxa/Naf/Methi-cillin; Amp/Amox-icillin (+claculanic acid or sulbactam); Carbeni/Ticar/Pipera/Mezlo-cillin
Term
Penicillin G/V
Definition
(V: rheumatic fever prophylaxis) S. aureus, S. pyogenes, Meningicoccus, Clostridia, Syphilis, Yaws, Leptospirosis (Seizures, C. difficile, eosinophilia, anemia, neuropathy, nephritis, anaphylaxis) [Hypersensitivity] G is intravenous. Potentiates warfarin
Term
Oxa/Cloxa/Dicloxa/Naf/Methi-cillin
Definition
S. aureus in skin/soft tissue (GI) [Hypersensitivity] Narrow Spectrum
Term
Oxacillin
Definition
(Hepatitis)
Term
Cloxa/Dicloxa-cillin
Definition
(Pseudomembranous enterocolitis)
Term
Nafcillin
Definition
(Interstitial nephritis, phlebitis)
Term
Antistaphylococcal Penicillins
Definition
Oxa/Cloxa/Dicloxa/Naf/Methi-cillin
Term
Amino Penicillins
Definition
Ampicillin, Amoxicillin. Positive charge on amino group aids entry.
Term
Ampicillin
Definition
Invasive Enterococci, Listeria (Rash, GI) [Hypersensitivity] Broad-spectrum
Term
Amoxicillin
Definition
ENT infections, endocarditis prophylaxis, dental surgery, part of H. pylori (Rash, GI) [Hypersensitivity]
Term
Clavulanic Acid, Sulbactam
Definition
Beta-lactamase inhibitors
Term
Ampicillin + Beta-Lactamase inhibitor
Definition
S. aureus, H. influenzae, e. coli, Klebsiella, Acinetobacter, Enterobacter, anaerobes (Same as ampicillin)
Term
Cephalosporins
Definition
inhibit transpeptidase by acyl enzyme intermediate. Six-membered accessory ring
Term
First generation cephalospirins
Definition
Cefazolin, Cephalexin
Term
Cefazolin, Cephalexin
Definition
Proeus mirabilis, E. coli, Klebsiella p. (Pseudomembranous enterocolitis, leukopenia, thrombocytopenia, hepatotoxicity, rash, GI) [specific hypersensivity] Good gram-positive, beta-lactamase sensitive
Term
Second Generation Cephalosporins
Definition
Cefuroxime, Cefotetan, Cefoxitin. Broader gram-negative coverage over generation 1
Term
Cefuroxime
Definition
H. influenzae. Primarily used in community-acquired pneumonia (Gen 1 adversia)
Term
Cefotetan, cefoxitin
Definition
H. influenzae, enterobacter, Neisseria, mirabilis, E. coli, Klebsiella (Gen 1 plus: Cefotetan may block Vit K coag factors with alcohol) Primarily abdominal/pelvic infections.
Term
Third Generation Cephalosporins
Definition
Cefotaxime, Ceftizoxime, Ceftriaxome, Cefoperazone, Ceftazidime. High CNS penetration, resistant to beta-lactamases, weak against gram-positives
Term
Ceftriaxone
Definition
Gonococcus, burgdorferi, H. influenzae, Enterobacteriaceae (Gen 1 plus: cholestatic hepatitis)
Term
Cefotaxime
Definition
H. influenzae
Term
Ceftazidime
Definition
P. aeruginosa
Term
Cefoperazone
Definition
(Vit K coag factor block with alcohol)
Term
Fourth Generation Cephalosporin
Definition
Cefepime
Term
Cefepime
Definition
Enterobacteriaceae, Neisseia, H. influenzae, P. aeruginosa, Gram-positives (Gen 1 plus: erythrocyte autoantibodies with hemolysis) beta-lactamase resistant
Term
Monobactams
Definition
Aztreonam, suicide inhibit transpeptidase
Term
Aztreonam
Definition
Gram-negative bacteria (same as penicillins) used in allergic patients, is ineffective for gram-positives
Term
Carbapenems
Definition
Imipenem/cilastatin, Meropenem, Ertapenem. Increase valproate levels.
Term
Carbapenem information
Definition
All gram+/- except MRSA, VRE, Legionella
Term
Imipenem/cliastatin
Definition
high levels may cause seizures, cliastatin inhibits renal dehydropeptidase I protective imipenem.
Term
Meropenem
Definition
High levels may cause seizures, levels increased by probenecid
Term
Ertapenem
Definition
Not active against Pseudomonas or Acinetobacter
Term
Ethambutol
Definition
Mycobacterium (Optic neuritis, blindness, peripheral neuropathy, neutropenia, thrombocytopenia, hyperuricemia, mania, GI) [Optic neuritis, antacids] Mycobacteriostatic with rifampin and streptomycin
Term
Ethambutol MOA
Definition
Decreases arabinogalactan synthesis by inhibiting arabinosyl transferase
Term
Pyrazinamide MOA
Definition
Produg converted to pyrazinoic acid, inhibits fatty acid synthetase I (FAS1)
Term
Pyrazinamide
Definition
Mycobacterium species (Anemia, hepatotoxicity, arthralgias, hyperuricemia) [gout, hepatic dysfunction]
Term
Isoniazid, Ethionamide
Definition
Mycobacterium (Hepatitis, neurotoxicity, SLE, seizure, hematologic abnomalities) [Active liver disease] Randomly modulate P450, pyridoxine supplementation treats Isoniazid neurotoxicity.
Term
Isoniazid, Ethionamide MOA
Definition
Inhibit mycolic acid synthesis by inhibiting Fatty Acid Synthetase 2 (FAS2)
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