- Glucocorticoid receptor agonist that mimic cortisol function by acting as agonists at the glucocorticoid receptor

- Inflammatory conditions

- Autoimmune diseases

- Replacement therapy for primary and secondary adrenal insufficiency

- Contraindicated in patients w/ systemic fungal infection

- tapered off slowly or can lead to acute adrenal insufficiency

- needs to be in active form if not in area that has 11β-HSDI (in liver)

- cleared from Kidney 11β-HSDII (kidney)

- last four are inhaled

- Competitive antagonist of cortisol action at the glucocorticoid receptor (type 2)

- Abortion (through 49th day)

-Ectopic ACTH tumor

- Inhibitor of glucocorticoid synthesis at rate limiting step

- Structural analogue of DDT

- Medical adrenalectomy in severe Cushing syndrome or andrenocortical carcinoma

- causes hypercholesterolemia

- inhibits side-chain cleavage enzyme as well as aromatase (androgens --> estrogens)

- Cushing's syndrome

- Inhibits 11β-hydroxylation, resulting in impaired cortisol synthesis

- disinhibition of ACTH secretion which allows for testing of ACTH reserve

- Diagnostic evaluation of hypothalamic-pituitary-adrenal axis

- Agonist at the mineralocorticoid receptor (type 1 glucocorticoid receptor)

- Hypoaldosteronism

- contraindicated in systemic fungal infections

- mimics a state of mineralocorticoid excess (hypertension, hypokalemia, cadiac failure)

- must monitor serum potassium level as well as BP

- Mineralocorticoid receptor antagonist that are competitive antagonists of aldosterone action at the receptor

- increases sodium levels

- Prohormone that is converted to testosterone in the periphery

- roids