Term
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Definition
sedation, tolerance, dependence |
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Term
sedation, tolerance, dependence - tox of which drugs? |
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Definition
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Term
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Definition
diplopia, ataxia, blood dyscrasias, liver tox, teratogenesis, induction of CYP, SIADH, SJ syndrome |
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Term
tox: diplopia, ataxia, blood dyscrasias, liver tox, teratogenesis, induction of CYP, SIADH, SJ syndrome. NAME THE DRUG. |
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Definition
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Term
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Definition
fatigue, GI, headache, urticaria, SJ syndrome |
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Term
tox: fatigue, GI, headache, urticaria, SJ syndrome. NAME THE DRUG. |
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Definition
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Term
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Definition
sedation, tolerance, dependence, induction of CYP450 |
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Term
tox: sedation, tolerance, dependence, induction of CYP450. NAME THE DRUG. |
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Definition
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Term
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Definition
nystagmus, diplopia, ataxia, sedation, gingival hyperplasia, hirsutism, megaloblastic anemia, teratogenesis (fetal hydantoin syn), SLE-like syndrome, induction of CYP |
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Term
Tox: nystagmus, diplopia, ataxia, sedation, gingival hyperplasia, hirsutism, megaloblastic anemia, teratogenesis (fetal hydantoin syn), SLE-like syndrome, induction of CYP. NAME THE DRUG. |
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Definition
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Term
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Definition
GI distress, rare but fatal hepatotoxicity (measure LFTs), neural tube defects, tremor, weight gain. Contraindicated in pregnancy. |
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Term
Tox: GI distress, rare but fatal hepatotoxicity (measure LFTs), neural tube defects, tremor, weight gain. Contraindicated in pregnancy. NAME THE DRUG. |
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Definition
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Term
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Definition
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Term
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Definition
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Term
Tox: sedation, ataxia. NAME THE DRUG. |
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Definition
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Term
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Definition
sedation, mental dulling, kidney stones, weight loss |
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Term
tox: sedation, mental dulling, kidney stones, weight loss. NAME THE DRUG |
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Definition
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Term
SJ syndrome - skin CELs come off. Which drugs cause it? |
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Definition
Carbamazepine, Ethosuximide, Lamotrigine |
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Term
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Definition
use-dependent blockade of Na channels, ^ refract period, inh of glutamate release from excitatory presyn neuron |
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Term
MOA: use-dependent blockade of Na channels, ^ refract period, inh of glutamate release from excitatory presyn neuron. NAME THE DRUG. |
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Definition
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Term
what is phenytoin used for besides seizures? |
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Definition
it's a class IB antiarrhythmic |
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Term
Chronic use of phenytoin produces... |
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Definition
gingival hyperplasia in kids, peripheral neuropathy, hirsutism, megaloblastic anemia |
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Term
Which drugs are NOT used for simple or complex partial seizures? |
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Definition
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Term
ethosuximide, benzos have no use in... |
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Definition
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Term
What are first-line agents for generalized tonic-clonic seizures? |
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Definition
Phenytoin, carbamazepine, valproic |
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Term
Phenytoin, carbamazepine, valproic - 1st line agents for... |
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Definition
generalized tonic-clonic seizures |
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Term
Which drugs are NOT used for generalized tonic-clonic seizures? |
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Definition
ethosux, benzos, tiagabine, vigabatrin |
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Term
ethosux, benzos, tiagabine, vigabatrin - NOT used for... |
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Definition
generalized tonic-clonic seizures |
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Term
What's the 1st line drug for absence seizures? What else can be used? |
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Definition
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Term
Ethosux is first line and valproic is backup drug for... |
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Definition
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Term
What's the 1st line drug for PROPHYLAXIS of status epilepticus? What's the 1st line for ACUTE TREATMENT? |
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Definition
phenytoin for prophylaxis, diazepam or lorazepam for acute |
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Term
What is phenytoin good for? |
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Definition
Partial, tonic clonic (1st), prophylaxis of status epilepticus (1st) |
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Term
______ is good for partial, tonic clonic, prophylaxis of status epilepticus |
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Definition
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Term
What is carbamazepine good for? |
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Definition
partial, tonic clonic (1st) |
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Term
________ is good for partial, tonic clonic (1st) |
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Definition
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Term
What is lamotrigine good for? |
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Definition
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Term
What is topiramate good for? |
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Definition
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Term
What is gabapentin good for? |
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Definition
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Term
What is phenobarbital good for? |
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Definition
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Term
What is levetiracetam good for? |
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Definition
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Term
What are the drugs that are ONLY used in partial and tonic-clonic seizures, not as 1st line? |
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Definition
lamotrigine, gabapentin, topiramate, phenobarbital, levetiracetam |
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Term
lamotrigine, gabapentin, topiramate, phenobarbital, levetiracetam -- these drugs are not 1st line agents, and they are only used in... |
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Definition
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Term
What is ethosux good for? |
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Definition
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Term
Which drug is only good for absence? |
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Definition
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Term
What are benzos good for? |
|
Definition
1st line for acute status |
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Term
Which drugs are only good for acute status (1st line)? |
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Definition
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Term
What is tiagabine good for? |
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Definition
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|
Term
what is vigabatrin good for? |
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Definition
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|
Term
Which drugs are used ONLY in partial seizures? |
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Definition
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Term
tiagabine and vigabatrin are used ONLY in... |
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Definition
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Term
Which drugs ^ Na+ channel inactivation? |
|
Definition
phenytoin and carbamazepine |
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Term
Which drugs work by ^ Na+ channel inactivation? |
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Definition
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Term
What is used for parenteral phenytoin administration? |
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Definition
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Term
Which drug is 1st line for trigeminal neuralgia? |
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Definition
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Term
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Definition
blocks voltage-gated Na+ channels |
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Term
Which drug blocks voltage-gated Na+ channels? |
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Definition
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Term
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Definition
designed as GABA analog, but primarily inhibits HVA Ca+ channels |
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Term
Which drug was designed as GABA analog, but primarily inhibits HVA Ca+ channels? |
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Definition
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Term
Which drug is also used for peripheral neuropathy and bipolar disorder? |
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Definition
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Term
gabapentin is also used for... |
|
Definition
peripheral neuropathy and bipolar |
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Term
Which drug blocks Na+ channels and increases action of GABA? |
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Definition
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Term
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Definition
blocks Na+ channels and increases action of GABA |
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Term
Which drugs ^ GABA-a action? |
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Definition
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Term
Which drug is the first line in pregnant women and children? |
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Definition
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|
Term
phenobarbital is 1st line in... |
|
Definition
pregnant women and children |
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Term
Which drug ^ Na+ channel inactivation AND ^ GABA concentration? |
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Definition
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Term
|
Definition
^Na+ channel inactivation and ^ GABA concentration |
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Term
Which drug is also used for myoclonic seizures? |
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Definition
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Term
valproic is also used for... |
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Definition
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|
Term
which drug blocks thalamic T-type Ca2+ channels? |
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Definition
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Term
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Definition
blocks T-type thalamic Ca2+ channels |
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Term
which drug is also used for seizures of eclampsia? |
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Definition
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|
Term
benzos are also used for seizures of... |
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Definition
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|
Term
what is the first line agent to prevent seizures of eclampsia? |
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Definition
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Term
|
Definition
1st line agent to prevent seizures of eclampsia |
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Term
which drug inhibits GABA reuptake? |
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Definition
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Term
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Definition
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Term
Which drug irreversibly inhibits GABA transaminase to increase GABA? |
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Definition
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Term
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Definition
irreversibly inhibits GABA transaminase to increase GABA |
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Term
Which drug has an unknown mechanism but may modulate GABA and glutamate release? |
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Definition
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Term
|
Definition
unknown, may modulate GABA and glutamate release |
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Term
Most frequent route of metabolism |
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Definition
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|
Term
Mechanisms of action for Phenytoin, Carbamazepine, Lamotrigine |
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Definition
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|
Term
MOA for Valproic acid at high doses |
|
Definition
Affect calcium, potassium, and sodium channels |
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Term
Drugs of choice for generalized tonic-clonic and partial seizures |
|
Definition
Valproic acid and Phenytoin |
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Term
|
Definition
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|
Term
Drugs of choice for absence seizures |
|
Definition
Ethosuximide and valproic acid |
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Term
Drug of choice for myoclonic seizures |
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Definition
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Term
Drugs that can be used for infantile spasms |
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Definition
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Term
Anti-seizure drugs used also for bipolar affective disorder (BAD) |
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Definition
Valproic acid, carbamazepine, phenytoin and gabapentin |
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Term
Anti-seizure drugs used also for Trigeminal neuralgia |
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Definition
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Term
Anti-seizure drugs used also for pain of neuropathic orgin |
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Definition
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Term
Anti-seizure agent that exhibits non-linear metabolism, highly protein bound, causes fetal hydantoin syndrome, and stimulates hepatic metabolism |
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Definition
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Term
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Definition
Gingival hyperplasia, nystagmus, diplopia and ataxia |
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Term
Anti-seizure agent that induces formation of liver drug-metabolism enzymes, is teratogen and can cause craniofacial anomalies and spina bifida |
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Definition
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Term
Agent that inhibits hepatic metabolism, is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress |
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Definition
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Term
Laboratory value required to be monitored for patients on valproic acid |
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Definition
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Term
|
Definition
Aplastic anemia and acute hepatic failure |
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Term
Anti-seizure medication also used in the prevention of migraines |
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Definition
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Term
Anti-seizure drugs used as alternative drugs for mood stabilization |
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Definition
Carbamazepine, gabapentin, lamotrigine, and valproic acid |
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|
Term
Which drugs INDUCE hepatic enzymes? |
|
Definition
barbs, carbamazepine, phenytoin |
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|
Term
Which drug INHIBITS hepatic enzyme metabolism? |
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Definition
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|
Term
Long term use of _____ is assoc with visual field defects |
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Definition
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|
Term
Withdrawal is most difficult for which drugs? |
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Definition
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|
Term
sulfonamides can displace _____ from its binding sites |
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Definition
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