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Pharm 21 - Intro to CNS drugs
Pharmacology of CNS receptors and drugs
72
Pharmacology
Professional
02/17/2012

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Term
Ach: where are cell bodies? How long are axons? What is the Renshaw synapse?
Definition
cell bodies at all levels, short and long, Motoneuron-Renshaw synapse
Term
Ach binds which M recepts? What are they blocked by?
Definition
M1 - blocked by pirenzepine and atropine
M2 - blocked by atropine
Term
M1: Excite or inhibit? How?
Definition
M1: excitatory - ^IP3 and DAG, dec K+ conductance
Term
M2: excite or inhibit? How?
Definition
M2: inhibitory - decrease cAMP, ^ K+ conductance
Term
Nicotinic recepts - excite or inhibit? How?
Definition
excite - ^ cation conductance
Term
Dopamine: where are the cell bodies? How long are the axons?
Definition
all levels, short, medium and long axons
Term
Which D receptor is inhibitory?
Definition
D1 AND D2
Term
D1: excite or inhibit? How? What blocks it?
Definition
D1 - inhibitory, ^cAMP (weird), blocked by phenothiazines
Term
D2: excite or inhibit? How? What blocks it?
Definition
D2: blocked by phenothiazines and haloperidol
presyn - inhibitory, dec Ca2+ conductance
postsyn - inhibitory, dec cAMP, ^K+ conductance
Term
Which D receptor increases cAMP?
Definition
D1
Term
Which D receptor is blocked by phenothiazines and haloperidol?
Definition
D2
Term
Norepi: where are the cell bodies? Where do they project?
Definition
Norepi - pons and brain stem, project to all levels
Term
a1 and b1 receptors are ________
Definition
excitatory
Term
which adrenergic receptors are excitatory?
Definition
a1 and b1
Term
which adrenergic receptors are inhibitory?
Definition
a2, b2
Term
a2 and b2 receptors are _______
Definition
inhibitory
Term
a1: excite or inhibit? How? What blocks it?
Definition
excite, ^IP3 and DAG, dec K+ conductance, blocked by prazosin
Term
which adrenoceptor uses IP3 and DAG?
Definition
a1
Term
What does prazosin block?
Definition
a1
Term
a2: excite or inhibit? How? What blocks it?
Definition
a2: inhibitory, ACTIVATED by clonidine
Presyn: dec Ca2+ conductance
Postsyn: dec cAMP, ^ K+ conductance
Term
which receptor does presyn inhibition by dec Ca2+ conductance and postsyn inhibition by dec cAMP and ^ K+ conductance?
Definition
a2
Term
a2 and b1 both affect _____ and _____ (intracellular messenger, ion)
Definition
cAMP, K+
Term
b1: excite or inhibit? How? What blocks it?
Definition
b1: excitatory, blocked by propranolol
^ cAMP, dec K+ conductance
Term
b2: excite or inhibit? How? What blocks it?
Definition
inhibitory, ? increase in electrogenic sodium pump, blocked by propranolol
Term
Which receptor may cause inhibition by increasing the electrogenic Na pump?
Definition
b2
Term
norepi acts on which receptors?
Definition
a1,a2,b1,b2
Term
serotonin: where are the cell bodies? where do they project?
Definition
pons and midbrain, project to all levels
Term
list the serotonin receptors
Definition
5-HT1a, 2a, 3 and 4
Term
Which 5-HT receptors are excitatory?
Definition
5-HT2a, 3, 4
Term
Which 5-HT receptors are inhibitory?
Definition
5-HT1a
Term
Which 5-HT receptors use cAMP?
Definition
5-HT4
Term
Which 5-HT receptors use IP3 and DAG?
Definition
5-HT2a
Term
name a partial agonist of 5-HT1a
Definition
buspirone
Term
What is the partial agonist of 5-HT1a?
Definition
buspirone
Term
5-HT1a: excite or inhibit? How? What blocks it?
Definition
inhibitory, ^ K+ conductance, buspirone is partial AGONIST
Term
Which drugs block 5-HT2a?
Definition
clozapine, risperidone, olanzapine
Term
clozapine, risperidone, olanzapine - they block which receptor?
Definition
5-HT2a
Term
5-HT2: excite or inhibit? How? What blocks it?
Definition
excitatory, ^IP3 and DAG, dec K+ conductance
clozapine, risperidone and olanzapine block it
Term
What blocks 5-HT3?
Definition
ondansetron
Term
ondansetron blocks...
Definition
5-HT3
Term
5-HT3: excite or inhibit? how? What blocks it?
Definition
excitatory, ^ cation conductance, blocked by ondansetron
Term
5-HT4: excite or inhibit? How?
Definition
5-HT4: excitatory, ^ cAMP, dec K+ conductance
Term
GABA: where are the neurons? what are they involved with?
Definition
supraspinal interneurons, spinal interneurons involved with presynaptic inhibition
Term
GABA-a is facilitated by...
Definition
benzos and zolpidem
Term
Benzos and zolpidem facilitate...
Definition
GABA-a
Term
GABA-b is activated by...
Definition
baclofen
Term
baclofen activates...
Definition
GABA-b
Term
GABA-a: excite or inhibit? how?
Definition
inhibitory, ^ Cl- conductance
Term
GABA-b: excite or inhibit? How?
Definition
inhibitory
presyn: dec Ca2+ conductance
postsyn: ^ K+ conductance
Term
Glutamate and aspartate are involved with _____ neurons at all levels
Definition
relay
Term
Which NTs are involved with relay neurons at all levels?
Definition
glutamate and aspartate
Term
NMDA is blocked by...
Definition
phencyclidine, ketamine and memantine
Term
phencyclidine, ketamine and memantine - they block which receptor?
Definition
NMDA
Term
NMDA - excite or inhibit? How?
Definition
excitatory, ^ Ca2+ or cation conductance
Term
There are metabotropic subtypes of aspartate and glutamate receptors. Are they inhibitory or excitatory? Presynaptic or postsynaptic?
Definition
presyn: inhibitory
postsyn: excitatory
Term
glutamate and aspartate - metabotropic presynaptic receptors: excite or inhibit? How?
Definition
inhibitory, dec cAMP, dec Ca2+ conductance
Term
glutamate and aspartate - metabotropic postsynaptic receptors: inhibitory or excitatory? How?
Definition
excitatory, ^IP3 and DAG, dec K+ conductance
Term
Glycine - where are its neurons?
Definition
interneurons in spinal cord and brain stem
Term
Glycine: excite or inhibit? How? Blocked by?
Definition
inhibitory, ^ Cl-, blocked by strychnine
Term
Which receptor is blocked by strychnine?
Definition
glycine
Term
What are the three major subtypes of opioid receptors?
Definition
mu, delta, kappa
Term
Are opioid receptors excitatory or inhibitory?
Definition
inhibitory
Term
How do presynaptic opioid receptors work?
Definition
inhibitory, dec Ca2+, dec cAMP
Term
how do postsynaptic opioid receptors work?
Definition
inhibitory, dec K+, dec cAMP
Term
hierarchical systems - describe them and their NTs
Definition
large myelinated, rapid conduction, excitatory: aspartate and glutamate
inhibitory: GABA and glycine
Term
Which type of system does this describe: large myelinated, rapid conduction, excitatory: aspartate and glutamate
inhibitory: GABA and glycine
Definition
hierarchical
Term
diffuse systems - describe them and their NTs
Definition
broad distribution, fine branching axons, varicosities.
Amines or peptides: NE, dopamine, serotonin
Affect attention, appetite, emotional stress
Term
which type of system does this describe: broad distribution, fine branching axons, varicosities.
Amines or peptides: NE, dopamine, serotonin
Affect attention, appetite, emotional stress
Definition
diffuse systems
Term
With the exception of 5-HT___, all the serotonin recepts are metabotropic
Definition
3
Term
Fast IPSPs are blocked by ______ receptor antagonists, and slow IPSPs are blocked by ______ receptor antagonists
Definition
GABA-a, GABA-b
Term
______ is a mediator of slow EPSPs in neurons involved with nociceptive sensory pathways in the spinal cord and brain stem
Definition
substance p
Term
______ are brain lipid derivatives that are synthesized and released postsynaptically after depolarization but travel backward presynaptically (retrograde) to decrease NT release
Definition
endocannabinoids
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