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PHAR100 Section E
E6
15
Pharmacology
Undergraduate 1
04/17/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Fixed combinations of estrogen and progestin
Definition
5th-25th day of cucle
Term
Multiphasic
Definition
fixed amount estrogen, variable amounts progestin, progestin increases from week to week
Term
Continuous estrogen progestin preparations
Definition
Estrogen progestin combinations taken for 28 days each cycle

estrogen inhibits GNRH, ovulation inhibited
Endometrium not optimal for implantation

Adverse effects: nausea, edema, headache, libido, reduced menstrual flow, weight gain, icnreased skin pigmentation, acne and hirsutism, vaginal and uterine infections more common, post-drug amenorrhea, cholestatic or obstructive jaundice, changes in carbohydrate metabolism, decrease folate absorption, thromboembolic disease, myocardial infaarction, stroke, hypertension, cancer
Term
Transdermal contraceptive patch
Definition
Contain ethinyl estrdiol and norelgestromin (progestin)
Term
Low-dose progestin, mini-pill
Definition
Daily dose progestin, breakthrough bleeding

Inhibits release GNRH and ovulation

Adverse effects: alter plasma lipids, breakthough bleeding
Term
Norplant
Definition
Silicone tubes filled with progestin implanted under skin, released over 5 years

Adverse effects: bleeding irregularities, weight gain, headache, nervousness, anxiety, muscular pain, breast discharge, abdominal discomfort
Term
Depoprovera
Definition
Injectable progestin injected every 3 months
Term
Antiprogestins (Mifepristone)
Definition
Blocks effect of progesterone on endometrium, lacks support of progesterone and lining is sloughed

Taken after missed period
Term
Post-Coital Contraceptives
Definition
Large doses of estrogen, delays or inhibits ovulation, major problem is nausea
Term
Intra-Uterine Device
Definition
Coil into uterus, prevents implantation of fertilized ovum, progestins embedded

Adverse effects: heavy menstrual flow, pelvic discomfort, 10-15% expelled spontaneously, uterine infections
Term
Diaphragm and Spermicidal Jelly
Definition
Diaphargm cap filled with agent which destroys sperm, placed over cervix, physical and chemical barrier

Disadvantages: properly fitted and used, inserted before coitus,remain 6-8 hours after coitus
Term
Male Condoms
Definition
Physical barrier, prevent spread STD, may tear or break
Term
Female Condoms
Definition
Physical barrier, prevent STD and pregnancy

Disadvantage: ease of insertion, dislodge
Term
Rhythm Method
Definition
Abstinence few days before and after ovulation
Term
Coituse Interruptus
Definition
Removal of penis before ejaculation, not effective some released before
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