Term
Three Classes antianginal drugs |
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Definition
Organic nitrates Beta-adrenergic antagonists Calcium Channel Blockers |
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Term
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Definition
First to describe Angina pectoris |
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Term
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Definition
Introduced sublingual nitroglycerin, lasts 20-30min |
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Term
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Definition
Introduced amyl nitrite by inhalation, lasts 3-5min |
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Term
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Definition
Due to lipid deposits in coronary arteries Pain from diminished oxygen supply |
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Term
Four 'E's precipitating Angina |
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Definition
Eating Exercise Excitement Exposure |
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Term
Mechanism of Action of Organic Nitrates |
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Definition
Vasodilation of large veins Dilate large coronary arteries |
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Term
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Definition
Converted in nitric oxide and into smooth muscle results in relaxation of blood vessel |
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Term
Enzyme nitric oxide synthase |
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Definition
Converts arginine into citrulline and nitric oxide |
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Term
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Definition
Absorbed into blood vessels quickly under tongue, effects 20-30min |
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Term
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Definition
Slow onset (1 hour) but long duration Rubbed onto skin |
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Term
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Definition
Long lasting but tolerance develops |
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Term
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Definition
Termination individual attack, prevention individual attack and chronic prophylaxis |
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Term
Beta-Adrenergic Blocking Agents |
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Definition
Block beta receptors in heart decreasing heart rate and myocardial contractility, cardiac output and myocardial oxygen requirements decrease |
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Term
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Definition
Beta-adrenergic blocking drug Decreases frequency of anginal attacks |
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Term
Nifedipine (Calcium Blocker) |
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Definition
Prevents sequence of events leading to constriction of arterioles, vascular smooth muscle remains dialate |
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Term
Cardiac glycosides (digitalis) |
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Definition
Binds to sodium, potassiume-ATPase and inhibits extrusion of sodium from cardiac cells, increase calcium, greater force of contraction |
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Term
Therapeutic Uses of Digitalis |
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Definition
Congestive heart failure, treatment disordered electrical rhythms of heart (arrhythmia) |
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Term
Adverse effects of digitalis |
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Definition
Nausea and vomiting, arrhythmia, blurred vision, headache, fatigue, muscle weakness, confusion |
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