clorpromazine

phenothiazine, aliphatic antipsychotic

prototype, low potency,

D1: inc Gs Gq

sedation, Anti-AchM, extrapyrimidal, strong orthostatic htn, H₁, miosis (unexpected), dec thermo, low anti-emetic

CI: seizures

phenothiazine, piperazine antipsychotic

CYP1A2, strong potentcy, extrapyrimidal

fluphenazine

phenothiazine, piperazine antipsychotic

CYP1A2, strong potentcy, extrapyrimidal

phenothiazine, piperazine antipsychotic

CYP1A2, strong potentcy, extrapyrimidal

phenothiazine, piperidine antipsychotic

paralysis of accommodation, mydriasis

sedation, anti-AchM, orthostatic htn, D_2, ventricular arrythemia

phenothiazine, piperidine antipsychotic

sedation, anti-AchM, orthostatic htn

phenothiazine, thioxanthene antipsychotic

less potent DA antagonist

phenothiazine, thioxanthene antipsychotic

less potent DA antagonist

butyrophenone antipsychotic

more potent DA antagonist

high extrapyrimidal (tardive dyskinesia)

treat Tourettes, Huntingtons

heterocyclic antipsychotic

heterocyclic antipsychotic

main tourettes

atypical antipsychotic

sedation, orthostatic htn, 5HT₂

20-24h

atypical antipsychotic

sedation, orthostatic htn

75-94h, CYP2D6

stabilizer agonist (D2S) antagonist (D2L), 5HT_1A metabolite D2 antagonist

SE: HA, nausea, vomiting, anxiety, insomnia, lightheadedness

atypical antipsychotic

sedation, orthostatic htn

5-10h

atypical antipsychotic

sedation, orthostatic htn, antiAch

atypical antipsychotic

sedation, orthostatic htn, anti-Ach

20-55h

weight gain

atypical antipsychotic

sedation, orthostatic htn, anti-Ach, agranulocytosis, low D₂ - low extrapyrimidal, weight gain

4-66h, CYP1A2,2D6

D₄, 5HT_2A, antiAchM